Neuroprotective activity of acetyl‐L‐carnitine: Studies in vitro

Journal of Neuroscience Research

Volumn 37, Issue 1, 1994, Pages 92-96

  Forloni, G ^a   Angeretti, N ^a   Smiroldo, S ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Alzheimer's disease; energy metabolism; glutamate neurotoxicity; amyloid

Indexed keywords

AMYLOID BETA PROTEIN; GLUTAMIC ACID; LEVACECARNINE; N METHYL DEXTRO ASPARTIC ACID;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN CORTEX; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; ENERGY METABOLISM; FETUS; HIPPOCAMPUS; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCARNITINE; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMAL; BLOOD PHYSIOLOGY; CATTLE; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; CULTURE MEDIA; ENERGY METABOLISM; GLUTAMATES; GLUTAMIC ACID; HIPPOCAMPUS; HUMAN; KAINIC ACID; N-METHYLASPARTATE; NEURONS; PEPTIDE FRAGMENTS; RATS; SUPPORT, NON-U.S. GOV'T;

EID: 0028107682     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.490370112     Document Type: Article

References (29)

1. Alternative excitotoxic hypotheses
2. Acetyl‐L‐carnitine in the rats hippocampus aging: Morphological, endocrine and behavioral correlates
3. Does impairment of energy metabolism result in excitoxic neuronal death in neurodegenerative illness?
4. 31P‐nuclear magnetic resonance spectroscopy
5. Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea
6. Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and neurochemical, neuropathological and cognitive correlations
7. Expression of amyloid precursor protein mRNAs in endothe lial, neuronal and glial cells, modulation by interleukin‐1
8. Apoptosis mediated neuronal degeneration induced by chronic application of β amyloid fragment 25–35
9. Neurotoxicity of prion protein fragment
10. Carnitine and its role in fatty acid metabolism
11. Effect of acety‐L‐Carnitine chronic treatment on discrimination model in aged rats
12. Neocortical metabolic abnormalities precede non‐memory cognitive deficits in early Alzheimer‐type and other dementias
13. Neurotoxicity at the N‐methyl‐D‐aspartate receptor in energy‐compromised neurons. An hypothesis for cell death in aging and disease
14. Carnitine acetyltransferase activity in the human brain and its microvessels is decreased in Alzheimer's disease
15. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
16. An in vivo model for the neurodegenerative effects of β‐amyloid and protection by substance P
17. Culture of dorsal root ganglion neurons from aged rats: Effects of acetyl‐L‐carnitine and NGF
18. Glutamate disfunction in Alzheimer's disease: An hypothesis
19. β‐Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitoxicity
20. Cytochrome oxidase deficiency in Alzheimer's disease
21. Prevention of postischemic canine neurological injury through potentation of brain energy metabolism by acetylcarnitine
22. Stimulation of oxidation of mitochondrial fatty acids and of acetate by acetylcarnitine
23. An immunocytochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain
24. Long‐term L‐acetylcarnitine treatment in Alzheimer's disease
25. Acetyl‐L‐carnitine enhances the response of PC12 cells to nerve growth factor
26. Stimulation of nerve growth factor receptors in PC12 by acetyl‐L‐carnitine
27. Physical basis of cognitive alteractions in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
28. Neurotrophic neurotoxic effects of amyloid β protein: Reversal by tachynin neuropeptides