Cellular mechanisms of muscle fatigue

Physiological Reviews

Volumn 74, Issue 1, 1994, Pages 49-94

  Fitts, R H ^a  

^a MARQUETTE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; LACTIC ACID; PHOSPHATE;

ACTION POTENTIAL; CELL PH; ELECTROENCEPHALOGRAM; GLYCOGEN MUSCLE LEVEL; GLYCOLYSIS; HEART MUSCLE FIBER MEMBRANE; MUSCLE CELL; MUSCLE FATIGUE; MUSCLE FIBRIL; MUSCLE INJURY; MUSCLE ISOMETRIC CONTRACTION; OXIDATION; PRIORITY JOURNAL; REVIEW; SARCOPLASMIC RETICULUM; TRANSVERSE TUBULAR SYSTEM; WORK CAPACITY;

EID: 0028107645     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.1994.74.1.49     Document Type: Review

References (496)

1. ABERCROMBIE, R. F., R. W. PUTNAM, AND A. ROOS. The intracellular pH of frog skeletal muscle: its regulation in isotonic solutions. J. Physiol. Lond. 345: 175-187, 1983.
2. 4 concentration do not decrease force in cat skeletal muscle. Am. J. Physiol. 260 (Cell Physiol. 29): C805-C812, 1991.
3. AHLBORG, B., J. BERGSTRÖM, L.-G. EKELUND, AND E. HULTMAN. Muscle glycogen and muscle electrolytes during prolonged physical exercise. Acta Physiol. Scand. 70: 129-142, 1967.
4. AHLBORG, G., P. FELIG, L. HAGENFELDT, R. HENDLER, AND J. WAHREN. Substrate turnover during prolonged exercise in man: splanchnic and leg metabolism of glucose, free fatty acids, and amino acids. J. Clin. Invest. 53: 1080-1090, 1974.
5. AICKIN, C. C., AND R. C. THOMAS. An investigation of the ionic mechanism of intracellular pH regulation in mouse soleus muscle fibers. J. Physiol. Lond. 273: 295-316, 1977.
6. ALJURE, E. F., AND L. M. BORRERO. The evolution of fatigue associated with isometric contraction in toad sartorius. J. Physiol. Lond. 194: 289-303, 1968.
7. ALJURE, E. F., AND L. M. BORRERO. The influence of muscle length on the development of fatigue in toad sartorius. J. Physiol. Lond. 199: 241-252, 1968.
8. ALLEN, D. G., J. A. LEE, AND H. WESTERBLAD. Intracellular calcium and tension during fatigue in isolated single muscle fibers from Xenopus laevis. J. Physiol. Lond. 415: 433-458, 1989.
9. ALLEN, D. G., H. WESTERBLAD, J. A. LEE, AND J. LÄNNERGREN. Role of excitation-contraction coupling in muscle fatigue. Sports Med. 13: 116-126, 1992.
10. 31P-NMR. J. Appl. Physiol. 63: 1428-1433, 1987.
11. ARMSTRONG, C. M., F. BEZANILLA, AND P. HOROWICZ. Twitches in the presence of ethylene glycol bis (β-aminoethyl ether)-N,N'-tetraacetic acid. Biochim. Biophys. Acta 267: 605-608, 1972.
12. ARMSTRONG, R. B. Mechanisms of exercise-induced delayed onset muscular soreness: a brief review. Med. Sci. Sports Exercise 16: 529-538, 1984.
13. ARMSTRONG, R. B., AND M. H. LAUGHLIN. Exercise-induced muscle fatigue. Muscle blood flow-fatigue relationship. In: International Series on Sport Sciences. Biochemistry of Exercise VI, edited by B. Saltin. Champaign, IL: Human Kinetics, 1986, vol. 16, p. 365-376.
14. ARMSTRONG, R. B., R. W. OGILVIE, AND J. A. SCHWANE. Eccentric exercise-induced injury to rat skeletal muscle. J. Appl. Physiol. 54: 80-93, 1983.
15. ARMSTRONG, R. B., C. W. SAUBERT IV, W. L. SEMBROWICH, R. E. SHEPHERD, AND P. D. GOLLNICK. Glycogen depletion in rat skeletal muscle fibers at different intensities and durations of exercise. Pfluegers Arch. 352: 243-256, 1974.
16. ARMSTRONG, R. B., G. L. WARREN, AND J. A. WARREN. Mechanisms of exercise-induced muscle fiber injury. Sports Med. 12: 184-207, 1991.
17. ASMUSSEN, E. Observations on experimental muscular soreness. Acta Rheum. Scand. 2: 109-116, 1956.
18. ASMUSSEN, E. Muscle fatigue. Med. Sci Sports Exercise 11:313-321, 1979.
19. ASMUSSEN, E., W. V. DOBELN, AND M. NIELSEN. Blood lactate and oxygen debt after exhaustive work at different oxygen tensions. Acta Physiol. Scand. 15: 57-62, 1948.
20. ÅSTRAND, P.-O., E. HULTMAN, A. JUHLIN-DANFELT, AND G. REYNOLDS. Disposal of lactate during and after strenuous exercise in humans. J. Appl. Physiol. 61: 338-343, 1986.
21. BALDWIN, K. M., G. H. KLINKERFUSS, R. L. TERJUNG, P. A. MOLÉ, AND J. O. HOLLOSZY. Respiratory capacity of white, red, and intermediate muscle: adaptative response to exercise. Am. J. Physiol. 222: 373-378, 1972.
22. BALOG, E. M., L. V. THOMPSON, AND R. H. FITTS. Effects of fatiguing stimulation on sarcolemmal action potentials (Abstract). Med. Sci. Sports Exercise 24, Suppl.: S91, 1992.
23. BANG, O. The lactate content of the blood during and after muscular exercise in man. Scand. Arch. Physiol. 74, Suppl. 10: 51-82, 1936.
24. 2 deficit-debt relationship during exhaustive exercise in humans. J. Physiol. Lond. 422: 539-559, 1990.
25. BÁRÁNY, M. ATPase activity of myosin correlated with speed of muscle shortening. J. Gen. Physiol. 50: 197-218, 1967.
26. BARCLAY, J. K., AND M. HANSEL. Free radicals may contribute to oxidative skeletal muscle fatigue. Can. J. Physiol. Pharmacol. 69: 279-284, 1991.
27. BEAM, G., AND C. M. KNUDSON. Calcium currents in embryonic and neonatal mammalian skeletal muscle. J. Gen. Physiol. 91: 781-798, 1991.
28. BELCASTRO, A. N., I. MACLEAN, AND J. GILCHRIST. Biochemical basis of muscular fatigue associated with repetitious contractions of skeletal muscle. Int. J. Biochem. 17: 447-453, 1985.
29. BELCASTRO, A. N., W. PARKHOUSE, G. DOBSON, AND J. S. GILCHRIST. Influence of exercise on cardiac and skeletal muscle myofibrillar proteins. Mol. Cell. Biochem. 83: 27-36, 1988.
30. BELCASTRO, A. N., M. ROSSITER, M. P. LOW, AND M. M. SOPPER. Calcium activation of sarcoplasmic reticulum ATPase following strenuous activity. Can. J. Physiol. Pharmacol. 59: 1214-1218, 1981.
31. BENZANILLA, F., C. CAUPTO, H. GONZALEZ-SERRATOS, AND R. A. VENOSA. Sodium dependence of the inward spread of activation in isolated twitch muscle fibers of the frog. J. Physiol. Lond. 223: 507-523, 1972.
32. BERG, G. H. Einige untersuchungen uber ermudung und restitution des ueberlebenden. M. sartorius beim frosch. Skand. Arch. Physiol. 24: 345-365, 1911.
33. BERGSTRÖM, J. Muscle electrolytes in man. Scand. J. Clin. Lab. Invest. 14, Suppl. 68: 1-110, 1962.
34. BERGSTRÖM, J., G. GUARNIERI, AND E. HULTMAN. Carbohydrate metabolism and electrolyte changes in human muscle tissue during heavy work. J. Appl. Physiol. 30: 122-125, 1971.
35. BERGSTRÖM, J., R. C. HARRIS, E. HULTMAN, AND L.-O. NORDESJO. Energy rich phosphagens in dynamic and static work. In: Advances in Experimental Medicine and Biology, edited by B. Pernow and B. Saltin. New York: Plenum, 1971, p. 341-355.
36. BERGSTRÖM, J., L. HERMANSEN, E. HULTMAN, AND B. SALTIN. Diet, muscle glycogen and physical performance. Acta Physiol. Scand. 71: 140-150, 1967.
37. BERGSTRÖM, J., AND E. HULTMAN. A study of the glycogen metabolsim during exercise in man. Scand. J. Clin. Lab. Invest. 19: 218-228, 1967.
38. BERGSTRÖM, J., AND E. HULTMAN. Relaxation time during intermittent isometric contraction in subjects with different capacity for oxidative work. Acta Physiol. Scand. 127: 107-110, 1986.
39. BERGSTRÖM, J., AND E. HULTMAN. Energy cost and fatigue during intermittent electrical stimulation of human skeletal muscle. J. Appl. Physiol. 65: 1500-1505, 1988.
40. BERGSTROM, M., AND E. HULTMAN. Relaxation and force during fatigue and recovery of the human quadriceps muscle: relations to metabolite changes. Pfluegers Arch. 418: 153-160, 1991.
41. BERQUIN, A., AND J. LEBACQ. Parvalbumin, labile heat and slowing of relaxation in mouse soleus and extensor digitorum longus muscles. J. Physiol. Lond. 445: 601-616, 1992.
42. BESSMAN, S. P., AND P. J. GEIGER. Transport of energy in muscle: the phosphorylcreatine shuttle. Science Wash. DC 211: 488-452, 1981.
43. BEVAN, L., Y. LAOURIS, R. M. REINKING, AND D. G. STUART. The effect of the stimulation pattern on the fatigue of single motor units in adult cats. J. Physiol. Lond. 449: 85-108, 1992.
44. BIANCHI, C. P., AND S. NARAYAN. Muscle fatigue and the role of transverse tubules. Science Wash. DC 215: 295-296, 1982.
45. BIANCHI, C. P., AND S. NARAYAN. Possible role of the transverse tubules in accumulating calcium released from the terminal cisternae by stimulation and drugs. Can. J. Physiol. Pharmacol. 60: 503-507, 1982.
46. BIGLAND-RITCHIE, B. EMG and fatigue of human voluntary and stimulated contractions. In: Human Muscle Fatigue: Physiological Mechanisms, edited by R. Porter and J. Whelan. London: Pitman Medical, 1981, p. 130-156. (Ciba Found. Symp. 82)
47. BIGLAND-RITCHIE, B. Muscle fatigue and the influence of changing neural drive. Clin. Chest Med. 5: 21-34, 1984.
48. BIGLAND-RITCHIE, B., F. BELLEMARE, AND J. J. WOODS. Excitation frequencies and sites of fatigue. In: Human Muscle Power, edited by N. L. Jones, N. McCarney, and A. J. McComas. Champaign, IL: Human Kinetics, 1986, p. 197-214.
49. BIGLAND-RITCHIE, B., N. J. DAWSON, R. S. JOHANSSON, AND O. C. J. LIPPOLD. Reflex origin for the slowing of motoneuron firing rates in fatigue of human voluntary contractions. J. Physiol. Lond. 379: 451-459, 1986.
50. BIGLAND-RITCHIE, B., R. JOHANSSON, O. C. J. LIPPOLD, AND J. WOODS. Contractile speed and EMG changes during fatigue of sustained maximal voluntary contractions. J. Neurophysiol. 50: 313-324, 1983.
51. BIGLAND-RITCHIE, B., R. JOHANSSON, AND J. J. WOODS. Does a reduction in motor drive necessarily result in force loss during fatigue? In: International Series on Sport Sciences. Biochemistry of Exercise, edited by H. G. Knuttgen, J. A. Vogel, and J. Poortmans. Champaign, IL: Human Kinetics, 1983, vol. 13, p. 864-870.
52. BIGLAND-RITCHIE, B., R. S. JOHANSSON, O. C. J. LIPPOLD, S. SMITH, AND J. J. WOODS. Changes in motorneuron firing rates during sustained maximal voluntary contractions. J. Physiol. Lond. 340: 335-346, 1983.
53. BIGLAND-RITCHIE, B., D. A. JONES, G. P. HOSKING, AND R. H. T. EDWARDS. Central and peripheral fatigue in sustained maximum voluntary contractions of human quadriceps muscle. Clin. Sci. Mol. Med. 54: 609-614, 1978.
54. BIGLAND-RITCHIE, B., D. A. JONES, AND J. J WOODS. Excitation frequency and muscle fatigue: electrical reponses during human voluntary and stimulated contractions. Exp. Neurol. 64: 414-427, 1979.
55. BINDER-MACLEOD, S. A., AND L. R. McDERMOND. Changes in the force-frequency relationship of the human quadriceps femoris muscle following electrically and voluntarily induced fatigue. Physical Therapy 72: 95-104, 1992.
56. 2+ binding of rabbit skeletal myofilaments. J. Biol. Chem. 259: 3181-3186, 1984.
57. BLINKS, J. R., R. RÜDEL, AND S. R. TAYLOR. Calcium transients in isolated amphibian skeletel muscle fibers: detection with aequorin. J. Physiol. Lond. 277: 291-323, 1978.
58. BLOCK, B. A., T. IMAGAWA, K. P. CAMPBELL, AND C. FRANZINI-ARMSTRONG. Structural evidence for direct interaction between the molecular components of the transverse tubule/sarcoplasmic reticulum junction in skeletal muscle. J. Cell Biol. 107: 2587-2600, 1988.
59. BLOMSTRAND, E., L. LARSSON, AND L. EDSTRÖM. Contractile properties, fatiguability and glycolytic metabolism in fast-and slow-twitch rat skeletal muscles of various temperatures. Acta Physiol. Scand. 125: 235-243, 1985.
60. +-activated force of skinned fibers from the soleus, cardiac and adductor magnus muscles of rabbits. Pfluegers Arch. 376: 55-65, 1978.
61. BORG, J., L. GRIMBY, AND J. HANNERZ. The fatigue of voluntary contraction and the peripheral electrical propagation of single motor units in man. J. Physiol. Lond. 340: 435-444, 1983.
62. BOTTINELLI, R., S. SCHIAFFINO, AND C. REGGIANI. Forcevelocity relations and myosin heavy chain isoform compositions of skinned fibers from rat skeletal muscle. J. Physiol. Lond. 437: 655-672, 1991.
63. 2+ sensitivity. J. Gen. Physiol. 79: 997-1016, 1982.
64. BREMEL, R. D., AND A. WEBER. Cooperation within actin filament in vertebrate skeletal muscle. Nature New Biol. 238: 97-101, 1972.
65. BRENNER, B. Mechanical and structural approaches to correlation of cross-bridge action in muscle with actomyosin ATPase in solution. Annu. Rev. Physiol. 49: 655-672, 1987.
66. 2+ on cross-bridge turnover kinetics in skinned single psoas fibers: implication for regulation of muscle contraction. Proc. Natl. Acad. Sci. USA 85: 3265-3269, 1988.
67. BRENNER, B., AND E. EISENBERG. Rate of force generation in muscle: correlation with actomyosin ATPase in solution. Proc. Natl. Acad. Sci. USA 83: 3542-3546, 1986.
68. BROOKE, M. H., AND K. K. KAISER. Muscle fiber types: how many and what kind? Arch. Neurol. 23: 369-379, 1970.
69. BROOKS, V. B., AND R. E. THIES. Reduction of quantum content during neuromuscular transmission. J. Physiol. Lond. 162: 298-310, 1962.
70. BROWN, G. L., AND B. D. BURNS. Fatigue and neuromuscular block in mammalian skeletal muscle. Proc. R. Soc. Lond. B Biol. Sci. 136: 182-195, 1949.
71. BRUM, G., R. FITTS, G. PIZARRO, AND E. RIOS. Voltage sensors of the frog skeletal muscle membrane require calcium to function in excitation-contraction coupling. J. Physiol. Lond. 398: 475-505, 1988.
72. BRUM, G., AND E. RIOS. Intramembrane charge movement in frog skeletal muscle fibers. Properties of charge 2. J. Physiol. Lond. 387: 489-517, 1987.
73. BRUM, G., E. RIOS, AND E. STEFANI. Effects of extracellular calcium on calcium movements of excitation-contraction coupling in frog skeletal muscle fibers. J. Physiol. Lond. 398: 441-473, 1988.
74. BRUMBACK, R. A., J. W. GERST, AND H. R. KNULL. High energy phosphate depletion in a model of defective muscle glycolysis. Muscle Nerve 6: 52-55, 1983.
75. BRUST, M. Changes in contractility of frog muscle due to fatigue and inhibitors. Am. J. Physiol. 206: 1043-1048, 1964.
76. BRUST, M. Fatigue and caffeine effects in fast-twitch muscles of the mouse. Pfluegers Arch. 367: 189-200, 1976.
77. BURKE, R. E., AND D. N. LEVINE. Mammalian motor units: physiological-histochemical correlation in three types in cat gastrocnemius. Science Wash. DC 174: 709-712, 1971.
78. BURKE, R. E., D. N. LEVINE, P. TSAIRIS, AND F. E. ZAJAC III. Physiological types and histochemical profiles in motor units of the cat gastrocnemius. J. Physiol. Lond. 234: 723-748, 1973.
79. BURKE, R. E., AND P. TSAIRIS. Anatomy and innervation ratios in motor units of cat gastrocnemius. J. Physiol. Lond. 234: 749-765, 1973.
80. BYRD, S. K. Alterations in the sarcoplasmic reticulum: a possible link to exercise-induced muscle damage. Med. Sci. Sports Exercise 24: 531-536, 1992.
81. BYRD, S. K., A. K. BODE, AND G. A. KLUG. Effects of exercise of varying duration on sarcoplasmic reticulum function. J. Appl. Physiol. 66: 1383-1389, 1989.
82. BYRD, S. K., L. J. McCUTCHEON, D. R. HODGSON, AND P. D. GOLLNICK. Altered sarcoplasmic reticulum function after high-intensity exercise. J. Appl. Physiol. 67: 2072-2077, 1989.
83. BYSTRÖM, S., AND G. SJØGAARD. Potassium homeostasis during and following exhaustive submaximal static handgrip contractions. Acta Physiol. Scand. 142: 59-66, 1991.
84. CADY, E. B., H. ELSHOVE, D. A. JONES, AND A. MOLL. The metabolic causes of slow relaxation in fatigued human skeletal muscle. J. Physiol. Lond. 418: 327-337, 1989.
85. CADY, E. B., D. A. JONES, J. LYNN, AND D. J. NEWHAM. Changes in force and intracellular metabolites during fatigue of human skeletal muscle. J. Physiol. Lond. 418: 311-325, 1989.
86. CANNELL, M. B. Effect of tetanus duration on the free calcium during the relaxation of frog skeletal muscle fibers. J. Physiol. Lond. 376: 203-218, 1986.
87. CAPUTO, C., P. BOLAÑOS, AND G. F. GONZALEZ. Effect of membrane polarization on contractile threshold and time course of prolonged contractile responses in skeletal muscle fibers. J. Gen. Physiol. 84: 927-943, 1984.
88. CAPUTO, C., G. GOTTSCHALK, AND H. C. LÜETTGAU. The control of contraction activation by the membrane potential. Experientia Basel 37: 580-581, 1981.
89. CASTLE, N. A., AND D. G. HAYLETT. Effect of channel blockers on potassium efflux from metabolically exhausted frog skeletal muscle. J. Physiol. Lond. 383: 31-43, 1987.
90. CHANDLER, W. K., R. F. RAKÖWSKI, AND M. F. SCHNEIDER. Effects of glycerol treatment and maintained depolarization on charge movement in skeletal muscle. J. Physiol. Lond. 254: 285-316, 1976.
91. CHASE, P. B., AND M. J. KUSHMERICK. Effects of pH on contraction of rabbit fast and slow skeletal muscle fibers. Biophys. J. 53: 935-946, 1988.
92. CHASIOTIS, D., K. SAHLIN, AND E. HULTMAN. Regulation of glycogenolysis in human muscle at rest and during exercise. J. Appl. Physiol. 53: 708-715, 1982.
93. CHEETHAM, M. E., L. H. BOOBIS, S. BROOKS, AND C. WILLIAMS. Human muscle metabolism during sprint running. J. Appl. Physiol. 61: 54-60, 1986.
94. CHRISTENSEN, E. H., AND O. HANSEN. Hypoglykamie, arbeitsfahigkeit and Ermudung. Skand. Arch. Physiol. 81: 172-179, 1939.
95. CLARKSON, P. M., K. NOSAKA, AND B. BRAUN. Muscle function after exercise-induced muscle damage and rapid adaptation. Med. Sci. Sports Exercise 24: 512-520, 1992.
96. CLAUSEN, T., AND M. E. EVERTS. Regulation of the Na,K-pump in skeletal muscle. Kidney Int. 35: 1-13, 1989.
97. + transport. Am. J. Physiol. 261 (Cell Physiol. 30): C799-C807, 1991.
98. CLAUSEN, T., M. E. EVERTS, AND K. KJELDSEN. Quantification of the maximum capacity for active sodium-potassium transport in rat skeletal muscle. J. Physiol. Lond. 388: 163-181, 1987.
99. CLOSE, R. I. Dynamic properties of mammalian skeletal muscles. Physiol. Rev. 52: 129-197, 1972.
100. COGGAN, A. R., AND E. F. COYLE. Reversal of fatigue during prolonged exercise by carbohydrate infusion or ingestion. J. Appl. Physiol. 63: 2388-2395, 1987.
101. COGGAN, A. R., AND E. F. COYLE. Effect of carbohydrate feedings during high-intensity exercise. J. Appl. Physiol. 65: 1703-1709, 1988.
102. COGGAN, A. R., AND E. F. COYLE. Carbohydrate ingestion during prolonged exercise: effects on metabolism and performance. In: Exercise and Sport Sciences Reviews, edited by J. O. Holloszy. Baltimore, MD: Williams & Wilkins, 1991, vol. 19, p. 1-40.
103. COGGAN, A. R., AND L. A. MENDENHALL. Effect of diet on substrate metabolism during exercise. In: Perspectives in Exercise Science and Sport Medicine. Energy Metabolism in Exercise and Sports, edited by D. R. Lamb and C. V. Gisolfi. Dubuque, IA: Brown & Benchmark, 1992, vol. 5, p. 435-471.
104. COOKE, R., AND W. BIALEK. Contraction of glycerinated muscle fibers as a function of the ATP concentration. Biophys. J. 28: 241-258, 1979.
105. COOKE, R., K. FRANKS, G. B. LUCIANI, AND E. PATE. The inhibition of rabbit skeletal muscle contraction by hydrogen ions and phosphate. J. Physiol. Lond. 395: 77-97, 1988.
106. COOKE, R., AND E. PATE. The effects of ADP and phosphate on the contraction of muscle fiber. Biophys. J. 48: 789-798, 1985.
107. COOKE, R., AND E. PATE. Addition of phosphate to active muscle fibers probes actomyosin states within the powerstroke. Pfluegers Arch. 414: 73-81, 1989.
108. COOPER, R. G., R. H. T. EDWARDS, H. GIBSON, AND M. J. STOKES. Human muscle fatigue: frequency dependence of excitation and force generation. J. Physiol. Lond. 397: 585-599, 1988.
109. COSTANTIN, L. L. The role of sodium current in the radial spread of contraction in frog muscle fibers. J. Gen. Physiol. 55: 703-715, 1970.
110. COSTILL, D. L., E. F. COYLE, G. DALSKY, W. EVANS, W. FINK, AND D. HOOPES. Effects of elevated plasma FFA and insulin on muscle glycogen usage during exercise. J. Appl. Physiol. 43: 695-699, 1977.
111. COSTILL, D. L., P. D. GOLLNICK, E. D. JANSSON, B. SALTIN, AND R. B. STEIN. Glycogen depletion pattern in human muscle fibers during distance running. Acta Physiol. Scand. 89: 374-383, 1973.
112. COSTILL, D. L., E. JANSSON, P. D. GOLLNICK, AND B. SALTIN. Glycogen utilization in the leg muscles of men during level and uphill running. Acta Physiol. Scand. 94: 475-481, 1974.
113. COYLE, E. F. Carbohydrate metabolism and fatigue. In: Muscle Fatigue: Biochemical and Physiological Aspects, edited by G. Atlan, L. Beliveau, and P. Bouissou. Paris: Masson, 1991, p. 153-164.
114. COYLE, E. F., A. R. COGGAN, M. K. HEMMERT, AND J. L. IVY. Muscle glycogen utilization during prolonged strenuous exercise when fed carbohydrate. J. Appl. Physiol. 61: 165-172, 1986.
115. COYLE, E. F., J. M. HAGBERG, B. F. HURLEY, W. H. MARTIN, A. A. EHSANI, AND J. O. HOLLOSZY. Carbohydrate feedings during prolonged strenuous exercise can delay fatigue. J. Appl. Physiol. 55: 230-235, 1983.
116. CREESE, R., S. E. E. HASHISH, AND N. W. SCHOLES. Potassium movements in contracting diaphragm muscle. J. Physiol. Lond. 143: 307-324, 1958.
117. CROW, M. T., AND M. J. KUSHMERICK. Chemical energetics of slow- and fast-twitch muscles of the mouse. J. Gen. Physiol. 79: 147-166, 1982.
118. CSERNOCH, L., G. PIZARRO, I. URIBE, M. RODRIQUEZ, AND E. RIOS. Interfering with calcium release suppresses Iγ, the de-layed component of intermembrane charge movement in skeletal muscle. J. Gen. Physiol. 97: 845-884, 1991.
119. CUMMINS, M. E., R. S. SOOMAL, AND N. A. CURTIN. Fatigue of isolated mouse muscle due to isometric tetani and tetani with high power output. Q. J. Exp. Physiol. 74: 951-953, 1989.
120. CURTIN, N. A. Intracellular pH and buffer power of type 1 and 2 fibers from skeletal muscle of Xenopus laevis. Pfluegers Arch. 408: 386-389, 1987.
121. CURTIN, N. A. Intracellular pH and relaxation of frog muscle. Adv. Exp. Med. Biol. 226: 657-669, 1988.
122. CURTIN, N. A., AND K. A. P. EDMAN. Effects of fatigue and reduced Intracellular pH on segment dynamics in isometric relaxation of frog muscle fibers. J. Physiol. Lond. 413: 159-174, 1989.
123. DAVIES, C. T. M., AND M. J. WHITE. Muscle weakness following eccentric work in man. Pfluegers Arch. 392: 168-171, 1981.
124. DAVIES, K. J. A., A. T. QUINTANILHA, G. A. BROOKS, AND L. PACKER. Free radicals and tissue damage produced by exercise. Biochem. Biophys. Res. Commun. 107: 1198-1205, 1982.
125. DAVIES, N. W., N. B. STANDEN, AND P. R. STANFIELD. The effect of intracellular pH on ATP-dependent potassium channels of frog skeletal muscle. J. Physiol. Lond. 445: 549-568, 1992.
126. 31P nuclear magnetic resonance spectroscopy. Adv. Exp. Med. Biol. 226: 433-448, 1988.
127. 31P nuclear magnetic resonance. J. Physiol. Lond. 267: 703-735, 1977.
128. DAWSON, M. J., D. G. GADIAN, AND D. R. WILKIE. Muscular fatigue investigated by phosphorus nuclear magnetic resonance. Nature Lond. 274: 861-866, 1978.
129. 31P NMR in conjunction with other techniques. Philos. Trans. R. Soc. Lond. B Biol. Sci. 289: 445-455, 1980.
130. DAWSON, M. J., D. G. GADIAN, AND D. R. WILKIE. Mechanical relaxation rate and metabolism studied in fatiguing muscle by phosphorus nuclear magnetic resonance. J. Physiol. Lond. 299: 465-484, 1980.
131. -] may determine cross-bridge cycling rate and force production in living fatiguing muscle (Abstract). Biophys. J. 49: 268a, 1986.
132. DE HAAN, A. High-energy phosphates and fatigue during repeated dynamic contractions of rat muscle. Exp. Physiol. 75: 851-854, 1990.
133. DE HAAN, A., M. A. N. LODDER, AND A. J. SARGEANT. Agerelated effects of fatigue and recovery from fatigue in rat medial gastrocnemius muscle. Q. J. Exp. Physiol. 74: 715-726, 1989.
134. DE LUCA, C. J., R. S. LEFEVER, M. P. MCCUE, AND P. XENAKIS. Behavior of human motor units in different muscles during linearly varying contractions. J. Physiol. Lond 329: 113-128, 1982.
135. DIAMANT, B., J. KARLSSON, AND B. SALTIN. Muscle tissue lactate after maximal exercise in man. Acta Physiol. Scand. 72: 383-384, 1968.
136. DILL, D. B., R. G. EDWARDS, AND J. H. TALBOTT. Factors limiting the capacity for work. J. Physiol. Lond. 77: 49-62, 1932.
137. DOHM, G. L., H. BARAKAT, T. P. STEPHENSON, S. N. PENNINGTON, AND E. B. TAPSCOTT. Changes in muscle mitochondrial lipid composition resulting from training and exhaustive exercise. Life Sci. 17: 1075-1080, 1975.
138. DOHM, G. L., R. L. HUSTON, E. W. ASKEW, AND H. L. FLESHWOOD. Effects of exercise, training, and diet on muscle citric acid cycle enzyme activity. Can. J. Biochem. 51: 849-854, 1973.
139. DOHM, G. L., R. L. HUSTON, E. W. ASKEW, AND P. C. WEISER. Effects of exercise on activity of heart and muscle mitochondria. Am. J. Physiol. 223: 783-787, 1972.
140. 2+-activated force of skinned fibers from the soleus, cardiac and adductor magnus muscle of rabbits. Pfluegers Arch. 376: 55-65, 1978.
141. DONALDSON, S. K. B. Effect of acidosis on maximum force generation of peeled mammalian skeletal muscle fibers. In: International Series on Sport Sciences. Biochemistry of Exercise, edited by H. G. Knuttgen, J. A. Vogel, and J. Poortmans. Champaign, IL: Human Kinetics, 1983, vol. 13, p. 126-133.
142. 2+] and injury from downhill walking. J. Appl. Physiol. 68: 1241-1251, 1990.
143. DUDLEY, G. A., W. M. ABRAHAM, AND R. L. TERJUNG. Influence of exercise intensity and duration on biochemical adaptations in skeletal muscle. J. Appl. Physiol. 53: 844-850, 1982.
144. DUDLEY, G. A., AND R. L. TERJUNG. Influence of aerobic metabolism on IMP accumulation in fast-twitch muscle. Am. J. Physiol. 248 (Cell Physiol. 17): C37-C42, 1985.
145. DULHUNTY, A. F. Effects of membrane potentials on mechanical activation in skeletal muscle. J. Gen. Physiol. 79: 233-251, 1983.
146. DUNCAN, C. J. Role of calcium in triggering rapid ultrastructural damage in muscle: a study with chemically skinned fibers. J. Cell Sci. 87: 581-594, 1987.
147. EBBELING, C. B., AND P. M. CLARKSON. Exercise-induced muscle damage and adaptation. Sports Med. 7: 207-234, 1989.
148. EBERSTEIN, A., AND A. SANDOW. Fatigue in phasic and tonic fibers of frog muscle. Science Wash. DC 134: 383-384, 1961.
149. EBERSTEIN, A., AND A. SANDOW. Fatigue mechanisms in muscle fibers. In: The Effect of Use and Disuse of Neuromuscular Function, edited by E. Gutmann and P. Hnik. Prague: Czech. Acad. Sci., 1963, p. 515-526.
150. EDMAN, K. A. P. The velocity of unloaded shortening and its relation to sarcomere length and isometric force in vertebrate muscle fibers. J. Physiol. Lond. 291: 143-159, 1979.
151. EDMAN, K. A. P., AND F. LOU. Changes in force and stiffness induced by fatigue and intracellular acidification in frog muscle fibers. J. Physiol. Lond. 424: 133-149, 1990.
152. EDMAN, K. A. P., AND A. R. MATTIAZZI. Effects of fatigue and altered pH on isometric force and velocity of shortening at zero load in frog muscle fibers. J. Muscle Res. Cell Motil. 2: 321-334, 1981.
153. EDSTROM, L., AND E. KUGELBERG. Histochemical composition, distribution of fibers and fatiguability of single motor units. J. Neurol. Neurosurg. Psychiatr. 31: 424-433, 1968.
154. EDWARDS, R. G., D. K. HILL, AND D. A. JONES. Fatigue of long duration in human skeletal muscle after exercise. J. Physiol. Lond. 272: 769-778, 1977.
155. EDWARDS, R. G., AND O. C. LIPPOLD. The relation between force and integrated electrical activity in fatigued muscle. J. Physiol. Lond. 132: 677-681, 1956.
156. EDWARDS, R. H. T. Human muscle function and fatigue. In: Human Muscle Fatigue: Physiological Mechanisms, edited by R. Porter and J. Whelan. London: Pitman Medical, 1981, p. 1-18. (Ciba Found. Symp. 82)
157. EDWARDS, R. H. T. Biochemcial bases of fatigue in exercise performance: catastrophe theory of muscular fatigue. In: Biochemistry of Exercise, edited by H. G. Knuttgen. Champaign, IL: Human Kinetics, 1983, p. 3-28.
158. EDWARDS, R. H. T., AND H. GIBSON. Perspectives in the study of normal and pathological skeletal muscle. In: Muscle Fatigue: Biochemical and Physiological Aspects, edited by G. Atlan, L. Beliveau, and P. Bouissou. Paris: Masson, 1991, p. 3-16.
159. EDWARDS, R. H. T., R. C. HARRIS, E. HULTMAN, L. KAIJSER, D. HOH, AND L.-O. NORDESJÖ. Effect of temperature on muscle energy metabolsim and endurance during successive isometric contractions sustained to fatigue, of the quadriceps muscle in man. J. Physiol. Lond. 220: 335-352, 1972.
160. EDWARDS, R. H. T., D. K. HILL, AND D. A. JONES. Metabolic changes associated with the slowing of relaxation in fatigued mouse muscle. J. Physiol. Lond. 251: 287-301, 1975.
161. EGGLETON, G. P., P. EGGLETON, AND A. V. HILL. The coefficient of diffusion of lactic acid through muscle. Proc. R. Soc. Lond. B Biol. Sci. 103: 620-628, 1928.
162. ENOKA, R. M., G. A. ROBINSON, AND A. R. KOSSEV. Task and fatigue effects on low-threshold motor units in human hand muscle. J. Neurophysiol. 62: 1344-1359, 1989.
163. ENOKA, R. M., AND D. G. STUART. Neurobiology of muscle fatigue. J. Appl. Physiol. 72: 1631-1648, 1992.
164. ESSEN, B. Intramuscular substrate utilization during prolonged exercise. Ann. NY Acad. Sci. 301: 30-44, 1977.
165. ESSEN, B., AND T. HAGGMARK. Lactate concentration in type I and II muscle fibers during muscular contraction in man. Acta Physiol. Scand. 95: 344-346, 1975.
166. EVERTS, M. E., K. RETTERSTOL, AND T. CLAUSEN. Effects of adrenaline on excitation-induced stimulation of the sodium-potassium pump in rat skeletal muscle. Acta Physiol. Scand. 134: 189-198, 1988.
167. FABIATO, A., AND F. FABIATO. Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiac and skeletal muscles. J. Physiol. Lond. 276: 233-255, 1978.
168. FENN, W. O., AND D. M. COBB. Electrolyte changes in muscle during activity. Am. J. Physiol. 115: 345-356, 1936.
169. FERENCZI, M. A., Y. E. GOLDMAN, AND R. M. SIMMONS. The dependence of force and shortening velocity on substrate concentration in skinned muscle fibres from Rana temporaria. J. Physiol. Lond. 350: 519-543, 1984.
170. FERGUSON, D. G., H. W. SCHWARTZ, AND C. FRANZINIARMSTRONG. Subunit structure of junctional feet in threads of skeletal muscle: a freeze-drying, rotary shadowing study. J. Cell Biol. 99: 1735-1742, 1984.
171. FILL, M., AND R. CORONADO. Ryanodine receptor channel of sarcoplasmic reticulum. Trends Neurosci. 11: 453-457, 1988.
172. + in metabolically exhausted muscle fibers. Eur. J. Cell Biol. 21: 109-115, 1980.
173. FINK, R., S. HASE, H. C. LÜETTGAU, AND E. WETTWER. The effect of cellular energy reserves and internal calcium ions on the potassium conductance in skeletal muscle of the frog. J. Physiol. Lond. 336: 211-228, 1983.
174. FINK, R., AND H. C. LÜETTGAU. An evaluation of the membrane constants and the potassium conductance in metabolically exhausted muscle fibers. J. Physiol. Lond. 263: 215-238, 1976.
175. FITCH, S., AND A. MCCOMAS. Influence of human muscle length on fatigue. J. Physiol. Lond. 362: 205-213, 1985.
176. FITTS, R. H. Substrate supply and energy metabolism during brief high intensity exercise: importance in limiting performance. In: Perspectives in Exercise Science and Sport Medicine. Energy Metabolism in Exercise and Sports, edited by D. R. Lamb and C. V. Gisolfi. Dubuque, IA: Brown & Benchmark, 1992, vol. 5, p. 53-99.
177. FITTS, R. H., E. M. BALOG, AND L. V. THOMPSON. Fatigue-induced alterations in contractile function: the role of excitation-contraction coupling. In: Muscle Fatigue: Biochemical and Physiological Aspects, edited by G. Atlan, L. Beliveau, and P. Bouissou. Paris: Masson, 1991, p. 39-48.
178. FITTS, R. H., F. W. BOOTH, W. W. WINDER, AND J. O. HOLLOSZY. Skeletal muscle respiratory capacity, endurance, and glycogen utilization. Am. J. Physiol. 228: 1029-1033, 1975.
179. FITTS, R. H., J. B. COURTRIGHT, D. H. KIM, AND F. A. WITZMAN. Muscle fatigue with prolonged exercise: contractile and biochemical alterations. Am. J. Physiol. 242 (Cell Physiol. 11): C65-C73, 1982.
180. FITTS, R. H., AND J. O. HOLLOSZY. Lactate and contractile force in frog muscle during development of fatigue and recovery. Am. J. Physiol. 231: 430-433, 1976.
181. FITTS, R. H., AND J. O. HOLLOSZY. Contractile properties of rat soleus muscle: effects of training and fatigue. Am. J. Physiol. 233 (Cell Physiol. 2): C86-C91, 1977.
182. FITTS, R. H., AND J. O. HOLLOSZY. Effects of fatigue and recovery on contractile properties of frog muscle. J. Appl. Physiol. 45: 899-902, 1978.
183. FITTS, R. H., D. H. KIM, AND F. A. WITZMANN. The development of fatigue during high intensity and endurance exercise. In: Exercise in Health and Disease, edited by F. J. Nagle and H. J. Montoye. Springfield, IL: Thomas, 1981, p. 118-135.
184. FITTS, R. H., AND J. M. METZGER. Mechanisms of muscular fatigue. In: Medicine and Sport Science. Principles of Exercise Biochemistry, edited by R. J. Poortmans. Basel: Karger, 1988, vol. 27, p. 212-229.
185. FITTS, R. H., F. J. NAGLE, AND R. G. CASSENS. Characteristics of skeletal muscle fiber types in the miniature pig and the effects of training. Can. J. Physiol. Pharmacol. 51: 825-831, 1973.
186. FLETCHER, W. M. The relation of oxygen to the survival metabolism of muscle. J. Physiol. Lond. 28: 474-498, 1902.
187. FLETCHER, W. M., AND G. HOPKINS. Lactic acid in amphibian muscle. J. Physiol. Lond. 35: 247-309, 1907.
188. FRANKENHAEUSER, B., AND J. LÄNNERGREN. The effect of calcium on the mechanical response of single twitch muscle fibers of Xenopus laevis. Acta PhysioL Scand. 69: 242-254, 1967.
189. FRANZINI-ARMSTRONG, C. Studies of the triad. I. Structure of the junction in frog twitch fibers. J. Cell Biol. 47: 488-499, 1970.
190. FREYGANG, W. H., D. A. GOLDSTEIN, AND D. C. HELLAM. The after-potential that follows trains of impulses in frog muscle fibers. J. Gen. Physiol. 47: 929-952, 1964.
191. FRIDEN, J., AND R. L. LIEBER. Structural and mechanical basis of exercise-induced muscle injury. Med. Sci. Sports Exercise 24: 521-530, 1992.
192. FRIDEN, J., R. L. LIEBER, AND L.-E. THORNELL. Subtle indications of muscle damage following eccentric contractions. Acta Physiol. Scand. 142: 523-524, 1991.
193. FURUSAWA, K., AND P. M. T. KERRIDGE. The hydrogen ion concentration of the muscles of the cat. J. Physiol. Lond. 63: 33-41, 1927.
194. GALE, J. B. Mitochondrial swelling associated with exercise and method of fixation. Med. Sci. Sports Exercise 6: 182-187, 1974.
195. GARCIA, M. D. C., H. GONZALEZ-SERRATOS, J. P. MORGAN, C. L. PERREAULT, AND M. ROZYCKA. Differential activation of myofibrils during fatigue in phasic skeletal muscle cells. J. Muscle Res. Cell Motil. 12: 412-424, 1991.
196. GARDINER, P. F., AND A. E. OLHA. Contractile and electromyographic characteristics of rat plantaris motor unit types during fatigue in situ. J. Physiol. Lond. 385: 13-34, 1987.
197. GLYN, H., AND J. SLEEP. Dependence of adenosine triphosphatase activity of rabbit psoas muscle fibers and myofibrils on substrate concentration. J. Physiol. Lond. 365: 259-276, 1985.
198. GODT, R. E. Calcium-activated tension of skinned muscle fibers of frog: dependence on magnesium adenosine triphosphate concentration. J. Gen. Physiol. 63: 722-739, 1974.
199. GODT, R. E., AND D. W. MAUGHAN. Influence of osmotic compression on calcium activation and tension in skinned muscle fibers of the rabbit. Pfluegers Arch. 391: 334-337, 1981.
200. GODT, R. E., AND D. W. MAUGHAN. On the composition of the cytosol of relaxed skeletal muscle of the frog. Am. J. Physiol. 254 (Cell Physiol. 23): C591-C604, 1988.
201. GODT, R. E., AND T. M. NOSEK. Changes of intracellular milieu with fatigue or hypoxia depress contraction of skinned rabbit skeletal and cardiac muscle. J. Physiol. Lond. 412: 155-180, 1989.
202. GOLLNICK, P. D. Energy metabolism and prolonged exercise. In: Perspectives in Exercise Science and Sports Medicine. Prolonged Exercise, edited by D. R. Lamb and R. Murray. Indianapolis, IN: Benchmark, 1988, vol. 1, p. 1-42.
203. GOLLNICK, P. D., B. ARMSTRONG, C. W. SAUBERT IV, W. L. SEMBROWICH, R. E. SHEPHERD, AND B. SALTIN. Glycogen depletion patterns in human skeletal muscle fibers during prolonged work. Pfluegers Arch. 344: 1-12, 1973.
204. GOLLNICK, P. D., B. ARMSTRONG, W. L. SEMBROWICH, R. E. SHEPHERD, AND B. SALTIN. Glycogen depletion pattern in human skeletal muscle fibers after heavy exercise. J. Appl. Physiol. 34: 615-618, 1973.
205. GOLLNICK, P. D., L. A. BERTOCCI, T. B. KELSO, E. H. WITT, AND D. R. HODGSON. The effect of high-intensity exercise on the respiratory capacity of skeletal muscle. Pfluegers Arch. 415: 407-413, 1990.
206. GOLLNICK, P. D., AND L. HERMANSEN. Biochemical adaptations to exercise: anaerobic metabolism. In: Exercise and Sport Sciences Reviews, edited by J. H. Wilmore. New York: Academic, 1973, p. 1-43.
207. GOLLNICK, P. D., J. KARLSSON, K. PIEHL, AND B. SALTIN. Selective glycogen depletion in skeletal muscle fibers of man following sustained contractions. J. Physiol. Lond. 241: 59-67, 1974.
208. GOLLNICK, P. D., AND D. W. KING. Effect of exercise and training on mitochondria of rat skeletal muscle. Am. J. Physiol. 216: 1502-1509, 1969.
209. GOLLNICK, P. D., P. KORGE, J. KARPAKKA, AND B. SALTIN. Elongation of skeletal muscle relaxation during exercise is linked to reduced calcium uptake by the sarcoplasmic reticulum in man. Acta Physiol. Scand. 142: 135-136, 1991.
210. GOLLNICK, P. D., K. PIEHL, AND B. SALTIN. Selective glycogen depletion pattern in human muscle fibres after exercise of varying intensity and at varying pedaling rates. J. Physiol. Lond. 241: 45-57, 1974.
211. GOLLNICK, P. D., K. PIEHL, C. W. SAUBERT IV, R. B. ARMSTRONG, AND B. SALTIN. Diet, exercise, and glycogen changes in human muscle fibers. J. Appl. Physiol. 33: 421-425, 1972.
212. GOMOLLA, M., G. GOTTSCHALK, AND H. C. LÜETTGAU. Perchlorate-induced alterations in electrical and mechanical parameters of frog skeletal muscle fibers. J. Physiol. Lond. 343: 197-214, 1983.
213. GONZALEZ-SERRATOS, H. Inward spread of activation in vertebrate muscle fibers. J. Physiol. Lond. 212: 777-799, 1971.
214. GONZALEZ-SERRATOS, H., A. V. SOMLYO, G. MCCLELLAN, H. SHUMAN, L. M. BORRERO, AND A. P. SOMLYO. Composition of vacuoles and sarcoplasmic reticulum in fatigued muscle: electron probe analysis. Proc. Natl. Acad. Sci. USA 75: 1329-1333, 1978.
215. GORDON, A. M., AND R. E. GODT. Some effects of hypertonic solutions on contraction and excitation-contraction coupling in frog skeletal muscles. J. Gen. Physiol. 55: 254-275, 1970.
216. GORDON, A. M., R. E. GODT, S. K. B. DONALDSON, AND C. E. HARRIS. Tension in skinned frog muscle fibers in solution of varying ionic strength and neutral salt composition. J. Gen. Physiol. 62: 550-574, 1973.
217. GORDON, B., L. A. KOHN, S. A. LEVINE, M. MATTON, W. M. DE SCRIVER, AND W. B. WHITING. Sugar content of the blood in runners following a marathon race. J. Am. Med. Assoc. 85: 508-509, 1925.
218. GORDON, D. A., R. M. ENOKA, G. M. KARST, AND D. G. STUART. Force development and relaxation in single motor units of adult cats during a standard fatigue test. J. Physiol. Lond. 421: 583-594, 1990.
219. GRABOWSKI, W., E. A. LOBSIGER, AND H. C. LÜETTGAU. The effect of repetitive stimulation at low frequencies upon the electrical and mechanical activity of single muscle fibers. Pfluegers Arch. 334: 222-239, 1972.
220. GREEN, H. J. How important is endogenous muscle glycogen to fatigue in prolonged exercise? Can. J. Physiol. Pharmacol. 69: 290-297, 1991.
221. GRIMBY, L., J. HANNERZ, AND B. HEDMAN. The fatigue and voluntary discharge properties of single motor units in man. J. Physiol. Lond. 316: 545-554, 1981.
222. GRISDALE, R. K., I. JACOBS, AND E. CAFARELLI. Relative effects of glycogen depletion and previous exercise on muscle force and endurance capacity. J. Appl. Physiol. 69: 1276-1282, 1990.
223. GYORKE, S. Effects of repeated tetanic stimulation on excitation-contraction coupling in cut muscle fibers of the frog. J. Physiol. Lond. 464: 699-710, 1993.
224. HÄKKINEN, K., AND P. V. KOMI. Effects of fatigue and recovery on electromyographic and isometric force- and relaxationtime characteristics of human skeletal muscle. Eur. J. Appl. Physiol. 55: 588-596, 1986.
225. HANSON, J. The effects of repetitive stimulation on the action potential and the twitch of rat muscle. Acta Physiol. Scand. 90: 387-400, 1974.
226. HANSON, J., AND A. PERSSON. Changes in the action potential and contraction of isolated frog muscle after repetitive stimulation. Acta Physiol. Scand. 81: 340-348, 1971.
227. HARRIS, R. C., R. H. T. EDWARDS, E. HULTMAN, AND L.-O. NORDESJÖ. The time course of phosphorylcreatine resynthesis during recovery of the quadriceps muscle in man. Pfluegers Arch. 367: 137-142, 1976.
228. HATCHER, D. D., AND A. R. LUFF. Force-velocity properties of fatigue-resistant units in cat fast-twitch muscle after fatigue. J. Appl. Physiol. 63: 1511-1518, 1987.
229. HERMANSEN, L. Anaerobic energy release. Med. Sci. Sports Exercise 1: 32-38, 1969.
230. HERMANSEN, L. Lactate production during exercise. In: Advances in Experimental Medicine and Biology. Muscle Metabolism During Exercise, edited by B. Pernow and B. Saltin. New York: Plenum, 1971, vol. 11, p. 401-407.
231. HERMANSEN, L. Effect of acidosis on skeletal muscle performance during maximal exercise in man. Bull. Eur. Physiopathol. Respir. 15: 229-238, 1979.
232. HERMANSEN, L., E. HULTMAN, AND B. SALTIN. Muscle glycogen during prolonged severe exercise. Acta Physiol. Scand. 71: 129-139, 1967.
233. HERMANSEN, L., A. ORHEIM, AND O. M. SEJERSTED. Metabolic acidosis and changes in water and electrolyte balance in relation to fatigue during maximal exercise of short duration. Int. J. Sports Med. 5: 110-115, 1984.
234. HERMANSEN, L., AND J. OSNES. Blood and muscle pH after maximal exercise in man. J. Appl. Physiol. 32: 304-308, 1972.
235. HERZIG, J. W., J. C. PETERSON, J. C. RÜEGG, AND R. J. SOLARO. Vanadate and phosphate ions reduce tension and increase cross-bridge kinetics in chemically skinned heart muscle. Biochim. Biophys. Acta 672: 191-196, 1981.
236. HIBBERD, M. G., J. A. DANTZIG, D. R. TRENTHAM, AND Y. K. GOLDMAN. Phosphate release and force generation in skeletal muscle fibers. Science Wash. DC 228: 1317-1319, 1985.
237. HICKS, A., AND A. McCOMAS. Increased sodium pump activity following repetitive stimulation of rat soleus muscles. J. Physiol. Lond. 414: 337-349, 1989.
238. HICKSON, R. C., M. J. RENNIE, R. K. CONLEE, W. W. WINDER, AND J. O. HOLLOSZY. Effects of increased plasma fatty acids on glycogen utilization and endurance. J. Appl. Physiol. 43: 829-833, 1977.
239. HIDALGO, C., AND E. JAIMOVICH. Inositol triphophate and excitation-contraction coupling in skeletal muscle. J. Bioenerg. Biomembr. 21: 267-282, 1989.
240. HILL, A. V. Myothermic experiments on the frog's gastrocnemius. Proc. R. Soc. Lond. B Biol. Sci. 109: 267-303, 1931.
241. HILL, A. V. The heat of shortening and dynamic constants of muscle. Proc. R. Soc. Lond. B Biol. Sci. 126: 136-195, 1938.
242. HILL, A. V. The influence of the external medium on the internal pH of muscle. Proc. R. Soc. Lond. B Biol. Sci. 144: 1-22, 1955.
243. HILL, A. V., AND P. KUPALOV. Anaerobic and aerobic activity in isolated muscles. Proc. R. Soc. Lond. B Biol. Sci. 105: 313-322, 1929.
244. HILL, A. V., AND H. LUPTON. Muscular exercise, lactic acid, and the supply and utilization of oxygen. Q. J. Med. 16: 135-171, 1923.
245. HINTZ, C. S., M. M. Y. CHI, R. D. FELL, J. L. IVY, K. K. KAISER, C. V. LOWRY, AND O. H. LOWRY. Metabolic changes in individual rat muscle fibers during stimulation. Am. J. Physiol. 242 (Cell Physiol. 21): C218-C228, 1982.
246. + balance of the gastrocnemius muscle of the dog during exercise. Pfluegers Arch. 387: 231-237, 1980.
247. HNIK, P., M. HOLAS, I. KREKULE, N. KRIZ, J. MEJSNAR, V. SMIESKO, E. UJEC, AND F. VYSKOCIL. Work-induced potassium changes in skeletal muscle and effluent venous blood assessed by liquid ion-exchanger microelectrodes. Pfluegers Arch. 362: 85-94, 1976.
248. + in single muscle fibers. J. Physiol. Lond. 145: 405-432, 1959.
249. HODGKIN, A. L., AND P. HOROWICZ. Potassium contractures in single muscle fibers. J. Physiol. Lond. 153: 386-403, 1960.
250. HOUGH, T. Ergographic studies in neuro-muscular fatigue. Am. J. Physiol. 5: 240-266, 1901.
251. HOUGH, T. Ergographic studies in muscular soreness. Am. J. Physiol. 7: 76-92, 1902.
252. HOWELL, J. N., AND H. OETLIKER. Effects of repetitive activity, ruthenium red, and elevated extracellular calcium on frog skeletal muscle: implications for t-tubule conduction. Can. J. Physiol. Pharmacol. 65: 691-696, 1987.
253. HOWELL, J. N., A. SHANKAR, S. G. HOWELL, AND F. WEI. Evidence for t-tubular conduction failure in frog skeletal muscle induced by elevated extracellular calcium concentration. J. Muscle Res. Cell Motil. 8: 229-241, 1987.
254. HOWELL, J. N., AND K. W. SNOWDOWNE. Inhibition of tetanus tension by elevated extracellular calcium concentration. Am. J. Physiol. 240 (Cell Physiol. 9): C193-C200, 1981.
255. HULTMAN, E., S. DEL CANALE, AND H. SJÖHOLM. Effect of induced metabolic acidosis on intracellular pH, buffer capacity and contraction force of human skeletal musele. Clin. Sci 69: 505-510, 1985.
256. HULTMAN, E., AND L. H. NILSSON. Liver glycogen in man. Effect of different diets and muscular exercise. In: Advances in Experimental Medicine and Biology. Muscle Metabolism During Exercise, edited by B. Pernow and B. Saltin. New York: Plenum, 1971, vol. 11, p. 143-151.
257. HULTMAN, E., AND H. SJÖHOLM. Electromyogram, force and relaxation time during and after continuous electrical stimulation of human skeletal muscle in situ. J. Physiol. Lond. 339: 33-40, 1983.
258. HULTMAN, E., AND H. SJÖHOLM. Biochemical causes of fatigue. In: Human Muscle Power, edited by N. L. Jones, N. McCartney, and A. J. McComas. Champaign, IL: Human Kinetics, 1986, p. 215-238.
259. HULTMAN, E., AND L. L. SPRIET. Skeletal muscle metabolism, contraction force and glycogen utilization during prolonged electrical stimulation in humans. J. Physiol. Lond. 374: 493-501, 1986.
260. HULTMAN, E., L. L. SPRIET, AND K. SÖDERLUND. Biochemistry of muscle fatigue. Biomed. Biochim. Acta 45: 97-106, 1986.
261. HUXLEY, A. F. The activation of striated muscle and its mechanical response. Proc. R. Soc. Lond. B Biol. Sci. 178: 1-27, 1971.
262. 2+-permeable pore of the calcium release channel. J. Biol. Chem. 262: 16636-16643, 1987.
263. INESI, G. Calcium and proton dependence of sarcoplasmic reticulum ATPase. Biophys. J. 44: 271-280, 1983.
264. 31P-NMR spectroscopy study in humans. Biochem. Biophys. Res. Commun. 478: 871-877, 1991.
265. IVY, J. L., M. M. Y. CHI, C. S. HINTZ, W. M. SHERMAN, R. P. HELLENDALL, AND O. H. LOWRY. Progressive metabolite changes in individual human muscle fibers with increasing work rates. Am. J. Physiol. 252 (Cell Physiol. 21): C630-C639, 1987.
266. JACKSON, M. J., D. A. JONES, AND R. H. T. EDWARDS. Experimental skeletal muscle damage: the nature of the calcium-activated degenerative processes. Em. J. Clin. Invest. 14: 369-374, 1984.
267. JACOBS, I., P. A. TESCH, O. BAR-OR, J. KARLSSON, AND R. DOTAN. Lactate in human skeletal muscle after 10 and 30 s of supramaximal exercise. J. Appl. Physiol. 55: 365-367, 1983.
268. JENKINS, R. R. Free radical chemistry: relationship to exercise. Sports Med. 5: 156-170, 1988.
269. JONES, D. A. Muscle fatigue due to changes beyond the neuromuscular junction. In: Human Muscle Fatigue: Physiological Mechanisms, edited by R. Porter and J. Whelan. London: Pitman Medical, 1981, p. 178-196. (Ciba Pound. Symp. 82)
270. JONES, D. A., AND B. BIGLAND-RITCHIE. Exercise-induced muscle fatigue. Electrical and contractile changes in muscle fatigue. In: International Series on Sport Sciences. Biochemistry of Exercise VI, edited by B. Saltin. Champaign, IL: Human Kinetics, 1986, vol. 6, p. 377-392.
271. JONES, D. A., B. BIGLAND-RITCHIE, AND R. H. T. EDWARDS. Excitation frequency and muscle fatigue: mechanical responses during voluntary and stimulated contractions. Exp. Neurol. 64: 401-413, 1979.
272. JONES, D. A., S. HOWELL, C. ROUSSOS, AND R. H. T. EDWARDS. Low-frequency fatigue in isolated skeletal muscle and the effects of methylxanthines. Clin. Sci. 63: 161-167, 1982.
273. JONES, D. A., M. J. JACKSON, G. MCPHAIL, AND R. G. EDWARDS. Experimental mouse muscle damage: the importance of external calcium. Clin. Sci. 66: 317-322, 1984.
274. JONES, D. A., D. J. NEWHAM, AND C. TORGAN. Mechanical influences on long-lasting human muscle fatigue and delayed-onset pain. J. Physiol. Lond. 412: 415-427, 1989.
275. JONES, N. L., AND G. J. F. HEIGENHAUSER. Effects of hydrogen ions on metabolism during exercise. In: Perspectives In Exercise Science and Sport Medicine. Energy Metabolism in Exercise and Sports, edited by D. R. Lamb and C. V. Gisolfi. Dubuque, IA: Brown & Benchmark, 1992, vol. 5, p. 107-148.
276. JUEL, C. Potassium and sodium shifts during in vitro isometric muscle contraction, and the time course of the ion-gradient recovery. Pfluegers Arch. 406: 458-463, 1986.
277. JUEL, C. Intracellular pH recovery and lactate efflux in mouse soleus muscles stimulated in vitro: the involvement of sodium/ proton exchange and a lactate carrier. Acta Physiol. Scand. 132: 363-371, 1988.
278. JUEL, C., J. BANGSBO, T. GRAHAM, AND B. SALTIN. Lactate and potassium fluxes from human skeletal muscle during and after intense, dynamic, knee extensor exercise. Acta Physiol. Scand. 140: 147-159, 1990.
279. JUEL, C., AND F. WIBRAND. Lactate transport in isolated mouse muscles studied with a tracer technique-kinetics, stereospecificity, pH dependencey and maximal capacity. Acta Physiol. Scand. 137: 33-39, 1989.
280. JULIAN, F. J., AND R. L. MOSS. Effects of calcium and ionic strength on shortening velocity and tension development in frog skinned muscle fibres. J. Physiol. Lond. 311: 179-199, 1981.
281. KARLSSON, J. Muscle ATP, CP, and lactate in submaximal exercise. In: Advances in Experimental Medicine and Biology. Muscle Metabolism During Exercise, edited by B. Pernow and B. Saltin. New York: Plenum, 1971, vol. 11, p. 383-393.
282. KARLSSON, J. Lactate and phosphagen concentrations in work-ing muscle of man. Acta Physiol. Scand. 81: 1-72, 1971.
283. KARLSSON, J., C. F. FUNDERBURK, B. ESSEN, AND A. R. LIND. Constituents of human muscle in isometric fatigue. J. Appl. Physiol. 38: 208-211, 1975.
284. KARLSSON, J., AND B. SALTIN. Lactate, ATP, and CP in working muscles during exhaustive exercise in man. J. Appl. Physiol. 29: 598-602, 1970.
285. KARLSSON, J., AND B. SALTIN. Diet, muscle glycogen, and endurance performance. J. Appl. Physiol. 31: 203-206, 1971.
286. KARLSSON, J., AND B. SALTIN. Oxygen deficit and muscle metaboulites in intermittent exercise. Acta Physiol. Scand. 82: 115-122, 1971.
287. KAWAI, M. The role of orthophosphate in crossbridge kinetics in chemically skinned rabbit psoas fibres as detected with sinusoidal and step length alterations. J. Muscle Res. Cell Motil. 7: 421-434, 1986.
288. KAWAI, M., K. GÜTH, K. WINNIKES, C. HAIST, AND J. C. RUEGG. The effect of inorganic phosphate on the ATP hydrolysis rate and the tension transients in chemically skinned rabbit psoas fibers. Pfluegers Arch. 408: 1-9, 1987.
289. KAWAI, M., AND H. R. HALVORSON. Role of MgATP and MgADP in the cross-bridge kinetics in chemically skinned rabbit psoas fibers: study of a fast exponential process. Biophys. J. 55: 595-603, 1989.
290. KAWAI, M., AND H. R. HALVORSON. Two step mechanism of phosphate release and the mechanism of force generation in chemically skinned fibers of rabbit psoas muscle. Biophys. J. 59: 329-342, 1991.
291. KENTISH, J. C. The effects of inorganic phosphate and creatine phosphate on force production in skinned muscles from rat ventricle. J. Physiol. Lond. 370: 585-604, 1986.
292. KERNELL, D., AND A. W. MONSTER. Motoneuron properties and motor fatigue. Exp. Brain Res. 46: 197-204, 1982.
293. KRASNER, B., AND D. MAUGHAN. The relationahip between ATP hydrolysis and active force in compressed and swollen skinned muscle fibers of the rabbit. Pfluegers Arch. 400: 160-165, 1984.
294. KREBS, E. G., D. J. GRAVES, AND E. H. FISCHER. Factors affecting the activity of muscle phosphorylase β kinase. J. Biol. Chem. 234: 2867-2873, 1959.
295. KRNJEVIC, K., AND R. MILEDI. Failure of neuromuscular propagation in rats. J. Physiol. Lond. 140: 440-461, 1958.
296. KRNJEVIC, K., AND R. MILEDI. Presynaptic failure of neuromuscular propagtion in rats. J. Physiol. Lond. 149: 1-22, 1959.
297. KUGELBERG, E., AND L. EDSTRÖM. Differential histochemical effects of muscle contractions on phosphorylase and glycogen in various types of fibers: relation to fatigue. J. Neurol. Neurosurg. Psychiatr. 31: 415-423, 1968.
298. KUGELBERG, E., AND B. LINDEGREN. Transmission and contraction fatigue of rat motor units in relation to succinate dehydrogenase activity of motor unit fibres. J. Physiol. Lond. 288: 285-300, 1979.
299. KUHN, H. J., C. BLETZ, K. GÜTH, AND J. C. RÜEGG. The effect of MgATP on forming and breaking actin-myosin linkages in contracted skinned insect flight muscle fibers. J. Muscle Res. Cell Motil. 6: 5-27, 1985.
300. KUSHMERICK, M. J., AND R. A. MEYER. Chemical changes in rat leg muscle by phosphorus nuclear magnetic resonance. Am. J. Physiol. 248 (Cell Physiol. 17): C542-C549, 1985.
301. KUSHMERICK, M. J., R. A. MEYER, AND T. R. BROWN. Phosphorus NMR spectroscopy of cat biceps and soleus muscles. Adv. Exp. Med. Biol. 1590: 303-325, 1983.
302. LAI, P. A., H. P. ERICKSON, E. ROUSSEAU, Q.-Y. LIU, AND G. MEISSNER. Purification and reconstitution of the calcium release channel from skeletal muscle. Nature Lond. 331: 315-319, 1988.
303. LAMB, G. D., E. RECUPERO, AND D. G. STEPHENSON. Effect of myoplasmic pH on excitation-contraction coupling in skeletal muscle fibres of the toad. J. Physiol. Lond. 448: 211-224, 1992.
304. LÄNNERGREN, J., L. LARSSON, AND H. WESTERBLAD. A novel type of delayed tension reduction observed in rat motor units after intense activity. J. Physiol. Lond. 412: 267-276, 1989.
305. LÄNNERGREN, J., AND H. WESTERBLAD. Force and membrane potential during and after fatiguing, continuous high-frequency stimulation of single Xenopus muscle fibres. Acta Physiol. Scand. 128: 350-368, 1986.
306. LÄNNERGREN, J., AND H. WESTERBLAD. Action potential fatigue in single skeletal muscle fibres of Xenopus. Acta Physiol. Scand. 129: 311-318, 1987.
307. +. J. Physiol. Lond. 409: 473-490, 1989.
308. LÄNNERGREN, J., AND H. WESTERBLAD. Force decline due to fatigue and intracellular acidification in isolated fibers from mouse skeletal muscle. J. Physiol. Lond. 434: 307-322, 1991.
309. LÄNNERGREN, J., H. WESTERBLAD, AND B. FLOCK. Transient appearance of vacuoles in fatigued Xenopus muscle fibers. Acta Physiol. Scand. 140: 437-445, 1990.
310. LARSSON, L., L. EDSTRÖM, B. LINDEGREN, L. GORZA, AND S. SCHIAFFINO. MHC composition and enzyme-histochemical and physiological properties of a novel fast-twitch motor unit type. Am. J. Physiol. 261 (Cell Physiol. 30): C93-C101, 1991.
311. LEVINE, S. A., G. GORDON, AND C. L. DERICK. Some changes in the chemcial constituents of the blood following a marathon race. J. Am. Med. Assoc. 82: 1778-1779, 1924.
312. LIEBER, R. L., T. M. WOODBURN, AND J. FRIDEN. Muscle damage induced by eccentric contractions of 23% strain. J. Appl. Physiol. 70: 2498-2507, 1991.
313. LINDHOLM, A., H. BJERNELD, AND B. SALTIN. Glycogen depletion pattern in muscle fibers of trotting horses. Acta Physiol. Scand. 90: 475-484, 1974.
314. LINDINGER, M. I., AND G. J. F. HEIGENHAUSER. Ion fluxes during tetanic stimulation in isolated perfused rat hindlimb. Am. J. Physiol. 254 (Regulatory Integrative Comp. Physiol. 23): R117-R126, 1988.
315. LINDINGER, M. I., AND G. J. F. HEIGENHAUSER. The roles of ion fluxes in skeletal muscle fatigue. Can. J. Physiol. Pharmacol. 69: 246-253, 1991.
316. LINDINGER, M. I., J. F. HEIGENHAUSER, AND L. L. SPRIET. Effects of intense swimming and tetanic electrical stimulation on skeletal muscle ions and metabolites. J. Appl. Physiol. 63: 2331-2339, 1987.
317. LINDINGER, M. I., AND G. SJØGAARD. Potassium regulation during exercise recovery. Sports Med, 11: 382-401, 1991.
318. LOMBARD, W. P. Some of the influences which affect the power of voluntary muscular contractions. J. Physiol. Lond. 13: 1-58, 1892.
319. LÜETTGAU, H. C. The action of calcium ions on potassium contractures of single muscle fibers. J. Physiol. Lond. 168: 679-697, 1963.
320. LÜETTGAU, H. C. The effect of metabolic inhibitors on the fatigue of the action potential in single muscle fibers. J. Physiol. Lond. 178: 45-67, 1965.
321. LÜETTGAU, H. C., G. GOTTSHALK, AND D. BERWE. The effect of calcium and Ca antagonists upon excitaion-contraction coupling. Can. J. Physiol. Pharmacol. 65: 717-723, 1987.
322. 2+-activated potassium conductance in metabolically exhausted skeletal muscle fibers. Cell Calcium 4: 331-341, 1983.
323. LYMN, R. W., AND E. W. TAYLOR. Mechanism of adenosine triphosphate hydrolysis by actomyosin. Biochemistry 10: 4617-4624, 1971.
324. MA, J., M. FILL, C. M. KNUDSON, K. P. CAMPBELL, AND R. CORONADO. Ryanodine receptor of skeletal muscle is a gap junction-type channel. Science Wash. DC 424: 99-102, 1988.
325. MACLAREN, D. P. M., H. GIBSON, M. PARRY-BILLINGS, AND R. H. T. EDWARDS. A review of metabolic and physiological factors in fatigue. In: Exercise and Sport Sciences Reviews, edited by K. B. Pandolf. Baltimore, MD: Williams & Wilkins, 1989, vol. 17, p. 29-66.
326. MAINWOOD, G. W., AND D. CECHETTO. The effect of bicarbonate concentration on fatigue and recovery in isolated rat diaphragm muscle. Can. J. Physiol. Pharmacol. 58: 624-632, 1980.
327. MAINWOOD, G. W., AND G. E. LUCIER. Fatigue and recovery in isolated frog sartorius muscles: the effects of bicarbonate concentration and associated potassium loss. Can. J. Physiol. Pharmacol 50: 132-142, 1972.
328. MAINWOOD, G. W., AND J. M RENAUD. The effect of acid-base balance on fatigue of skeletal muscle. Can. J. Physiol. Pharmacol. 63: 403-416, 1985.
329. MAINWOOD, G. W., J. M. RENAUD, AND M. J. MASON. The pH dependence of the contractile response of fatigued skeletal muscle. Can. J. Physiol. Pharmacol. 65: 648-658, 1987.
330. MAINWOOD, G. W., AND P. WORSLEY-BROWN. The effects of extracellular pH and buffer concentration on the efflux of lactate from frog sartorius muscle. J. Physiol. Lond. 250: 1-22, 1975.
331. MAINWOOD, G. W., P. WORSLEY-BROWN, AND R. A. PATERSON. The metabolic changes in frog sartorius muscles during recovery from fatigue at different external bicarbonate concentrations. Can. J. Physiol. Pharmacol. 50: 143-155, 1972.
332. MARGARIA, R., H. T. EDWARDS, AND D. B. DILL. The possible mechanism of contracting and paying the oxygen debt and the role of lactic acid in muscular contraction. Am. J. Physiol. 106: 689-715, 1933.
333. MARTONOSI, A. Sarcoplasmic reticulum. J. Biol. Chem. 244: 613-620, 1969.
334. MARTYN, D. A., AND A. M. GORDON. Force and stiffness in glycerinated rabbit psoas fibers. Pfluegers Arch. 99: 795-816, 1992.
335. MASON, M. J., AND R. C. THOMAS. A microelectrode study of the mechanisms of L-lactate entry into and release from frog sartorius muscle. J. Physiol. Lond. 400: 459-479, 1988.
336. MCCARTNEY, N., G. J. F. HEIGENHAUSER, AND N. L. JONES. Effects of pH on maximal power output and fatigue during shortterm dynamic exercise. J. Appl. Physiol. 55: 225-229, 1983.
337. MCCARTNEY, N., L. L. SPRIET, G. J. F. HEIGENHAUSER, J. M. KOWALCHUK, J. R. SUTTON, AND N. L. JONES. Muscle power and metabolism in maximal intermittent exercise. J. Appl. Physiol. 60: 1164-1169, 1986.
338. MCCULLY, K. K. Exercsie-induced injury to skeletal muscle. Federation Proc. 45: 2933-2936, 1986.
339. MCCULLY, K. K., B. BODEN, M. TUCHLER, M. R. FOUNTAIN, AND B. CHANCE. Wrist flexor muscles of elite rowers measured with magnetic resonance spectroscopy. J. Appl. Physiol. 67: 926-932, 1989.
340. MCCULLY, K. K., B. J. CLARK, J. A. KENT, J. WILSON, AND B. CHANCE. Biochemical adaptations to training: implications for resisting muscle fatigue. Can. J. Physiol. Pharmacol. 69: 274-278, 1991.
341. MCCULLY, K. K., AND J. A. FAULKNER. Injury to skeletal muscle fibers of mice following lengthening contractions. J. Appl. Physiol. 59: 119-126, 1985.
342. McCULLY, K. K., AND J. A. FAULKNER. Characteristics of lengthening contractions associated with injury to skeletal muscle fibers. J. Appl. Physiol. 61: 293-299, 1986.
343. MCCULLY, K. K., W. L. SEMBROWICH, W. J. BANK, AND J. D. POSNER. The use of nuclear magnetic resonance to evaluate muscle injury. Med. Sci. Sports Exercise 24: 537-542, 1992.
344. MCCUTCHEON, L. J., S. K. BYRD, AND D. R. HODGSON. Ultra-structural changes in skeletal muscle after fatiguing exercise. J. Appl. Physiol. 72: 1111-1117, 1992.
345. MEDBO, J. I., AND O. M. SEJERSTED. Plasma potassium changes with high intensity exercise. J. Physiol. Lond. 421: 105-122, 1990.
346. MERTON, P. A. Voluntary strength and fatigue. J. Physiol. Lond. 123: 553-564, 1954.
347. METZGER, J. M. Mechanism of chemomechanical coupling in skeletal muscle during work. In: Perspectives in Exercise Science and Sport Medicine. Energy Metabolism in Exercise and Sports, edited by D. R. Lamb and C. V. Gisolfi. Dubuque, IA: Brown & Benchmark, 1992, vol. 5, p. 1-44.
348. METZGER, J. M., AND R. H. FITTS. Fatigue from high- and lowfrequency muscle stimulation: role of sarcolemma action potentials. Exp. Neurol. 93: 320-333, 1986.
349. METZGER, J. M., AND R. H. FITTS. Role of intracellular pH in muscle fatigue. J. Appl. Physiol. 62: 1392-1397, 1987.
350. METZGER, J. M., AND R. H. FITTS. Fatigue from high- and lowfrequency muscle stimulation: contractile and biochemical alterations. J. Appl. Physiol. 62: 2075-2082, 1987.
351. METZGER, J. M., M. L. GREASER, AND R. L. MOSS. Variations in cross-bridge attachment rate and tension with phosphorylation of myosin in mammalian skinned skeletal muscle fibers. J. Gen. Physiol. 93: 855-883, 1989.
352. METZGER, J. M., AND R. L. MOSS. Greater hydrogen ion-induced depression of tension and velocity in skinned single fibers of rat fast than slow muscles. J. Physiol. Lond. 393: 727-742, 1987.
353. METZGER, J. M., AND R. L. MOSS. Shortening velocity in skinned single muscle fibers. Biophys. J. 52: 127-131, 1987.
354. METZGER, J. M., AND R. L. MOSS. Effects on tension and stiffness due to reduced pH in mammalian fast- and slow-twitch skinned skeletal muscle fibers. J. Physiol. Lond. 428: 737-750, 1990.
355. 2+-sensitive cross-bridge state transition in mammalian single skeletal muscle fibers. J. Physiol. Lond. 428: 751-764, 1990.
356. METZGER, J. M., AND R. L. MOSS. Calcium-sensitive crossbridge transitions in mammalian fast and slow skeletal muscle fibers. Science Wash. DC 247: 1088-1090, 1990.
357. MEYER, R. A., T. R. BROWN, AND M. J. KUSHMERICK. Phosphorus nuclear magnetic resonance of fast- and slow-twitch muscle. Am. J. Physiol. 248 (Cell Physiol. 17): C279-C287, 1985.
358. MEYER, R. A., G. A. DUDLEY, AND R. L. TERJUNG. Ammonia and IMP in different skeletal muscle fibers after exercise in rats. J. Appl. Physiol. 49: 1037-1041, 1980.
359. 31P-NMR spectroscopy to the study of striated muscle metabolism. Am. J. Physiol. 242 (Cell Physiol. 11): C1-C11, 1982.
360. MEYER, R. A., H. L. SWEENEY, AND M. J. KUSHMERICK. A simple analysis of the "phosphocreatine shuttle." Am. J. Physiol. 246 (Cell Physiol. 15): C365-C377, 1984.
361. MEYER, R. A., AND R. L. TERJUNG. Differences in ammonia and adenylate metabolism in contracting fast and slow muscle. Am. J. Physiol. 237 (Cell Physiol. 6): C111-C118, 1979.
362. MILLAR, N. C., AND E. HOMSHER. The effect of phosphate and calcium on force generation in glycerinated rabbit skeletal muscle fibers. J. Biol. Chem. 265: 20234-20240, 1990.
363. 31P nuclear magnetic resonance studies of high energy phosphates and pH in human muscle fatigue. J. Clin. Invest. 81: 1190-1196, 1988.
364. MILLER, R. G., D. GIANNINI, H. S. MILNER-BROWN, R. B. LAYZER, A. P. KORETSKY, D. HOOPER, AND M. W. WEINER. Effects of fatiguing exercise on high-energy phosphates, force, and EMG: evidence for three phases of recovery. Muscle Nerve 10: 810-821, 1987.
365. MILNER-BROWN, H. S., M. MELLENTHIN, AND R. G. MILLER. Quantifying human muscle strength, endurance and fatigue. Arch. Phys. Med. Rehabil. 67: 530-535, 1986.
366. MILNER-BROWN, H. S., AND R. G. MILLER. Muscle membrane excitation and impulse propagation velocity are reduced during muscle fatigue. Muscle Nerve 9: 367-374, 1986.
367. MURALI, K., D. PAGALA, N. TATSUJI, AND A. GROB. Failure of neuromuscular transmission and contractility during muscle fatigue. Muscle Nerve 7: 454-464, 1984.
368. MUTCH, B. J. C., AND E. W. BANISTER. Ammonia metabolism in exercise and fatigue: a review. Med. Sci. Sports Exercise 15: 41-50, 1983.
369. NADEL, E. R. Temperature regulation and prolonged exercise. In: Prespectives in Exercise Science and Sports Medicine. Prolonged Exercise, edited by D. R. Lamb and R. Murray. Indianapolis, IN: Benchmark, 1988, vol. 1, p. 125-151.
370. NAGESSER, A. S., W. J. VAN DER LAARSE, AND G. ELZINGA. Metabolic changes with fatigue in different types of single muscle fibers of Xenopus laevis. J. Physiol. Lond. 448: 511-523, 1992.
371. NAKAMARU, Y., AND A. SCHWARTZ. The influence of hydrogen ion concentration on calcium binding and release by skeletal muscle sarcoplasmic reticulum. J. Gen. Physiol. 59: 22-32, 1972.
372. NASSAR-GENTINA, V., J. V. PASSONNEAU, AND S. I. RAPOPORT. Fatigue and metabolism of frog muscle fibers during stimulation and in response to caffeine. Am. J. Physiol. 241 (Cell Physiol. 10): C160-C166, 1981.
373. NASSAR-GENTINA, V., J. V. PASSONNEAU, J. L. VERGARA, AND S. I. RAPOPORT. Metabolic correlates of fatigue and of recovery from fatigue in single frog muscle fibers. J. Gen. Physiol. 72: 593-606, 1978.
374. NEWHAM, D. J., D. A. JONES, AND P. M. CLARKSON. Repeated high-force eccentric exercise: effects on muscle pain and damage. J. Appl. Physiol. 63: 1381-1396, 1987.
375. NEWHAM, D. J., D. A. JONES, G. GHOSH, AND P. AURORA. Muscle fatigue and pain after eccentric contractions at long and short length. Clin. Sci. 74: 553-557, 1988.
376. NEWHAM, D. J., G. MCPHAIL, AND R. H. T. EDWARDS. Ultrastructural changes after concentric and eccentric contractions of human muscle. J. Neurol. Sci. 61: 109-122, 1983.
377. NEWHAM, D. J., K. R. MILLS, B. M. QUIGLEY, AND R. H. T. EDWARDS. Pain and fatigue after concentric and eccentric muscle contractions. Clin. Sci. 64: 55-62, 1983.
378. NIMMO, M. A., AND D. H. SNOW. Time course of ultrastructural changes in skeletal muscle after two types of exercise. J. Appl. Physiol. 52: 910-913, 1982.
379. NOSEK, T. M., K. Y. FENDER, AND R. E. GODT. It is deprotonated inorganic phosphate that depresses force in skinned skeletal muscle fibers. Science Wash. DC 236: 191-193, 1987.
380. 3) within diaphragm muscle increases upon depolarization (Abstract). Biophys. J. 57: 401a, 1990.
381. NOSEK, T. M., J. H. LEAL-CARDOSO, M. McLAUGHLIN, AND R. E. GODT. Inhibitory influence of phosphate and arsenate on contraction of skinned skeletal and cardiac muscle. Am. J. Physiol. 259 (Cell Physiol. 28): C933-C939, 1990.
382. 2+, ionic strength and pH. J. Biol. Chem. 97: 1011-1023, 1985.
383. OGILVIE, R. W., R. B. ARMSTRONG, K. E. BAIRD, AND C. L. BOTTOMS. Lesions in the rat soleus muscle following eccentrically biased exercise. Am. J. Anat. 182: 335-346, 1988.
384. OSNES, J., AND L. HERMANSEN. Acid-base balance after maximal exercise of short duration. J. Appl. Physiol. 32: 59-63, 1972.
385. PARKINSON, J. L. The effect of activity on the form of the muscle twitch. J. Physiol. Lond. 78: 106-112, 1933.
386. PATE, E., AND R. COOKE. A model of crossbridge action: the effects of ATP, ADP, and Pi. J. Muscle Res. Cell Motil. 10: 181-196, 1989.
387. PEACHEY, L. D. The sarcoplasmic reticulum and transverse tubules of the frog's sartorius. J. Cell Biol. 25: 209-231, 1965.
388. PELLEGRINO, C., AND C. FRANZINI. An electron microscope study of denervation atrophy in red and white skeletal muscle fibers. J. Cell Biol. 17: 327-349, 1963.
389. PERNOW, B., AND B. SALTIN. Availability of substrates and capacity for prolonged heavy exercise in man. J. Appl. Physiol. 31: 416-422, 1971.
390. PETER, J. B. Histochemical, biochemical, and physiological studies of skeletal muscle and its adaptation to exercise. In: Contractility of Muscle Cells and Related Processes, edited by R. J. Podolsky. Englewood Cliffs, NJ: Prentice-Hall, 1971, p 151-173.
391. PIZARRO, G., R. FITTS, I. URIBE, AND E. RIOS. The voltage sensor of excitation contraction coupling in skeletal mescle. Ion dependence and selectivity. J. Gen. Physiol. 94: 405-428, 1989.
392. REN, J.-M., AND E. HULTMAN. Regulation of glycogenolysis in human skeletal muscle. J. Appl. Physiol. 67: 2243-2248, 1989.
393. REN, J.-M., AND E. HULTMAN. Regulation of phosphorylase activity in human skeletal muscle. J. Appl. Physiol. 69: 919-923, 1990.
394. RENAUD, J. M. Is the change in intracellular pH during fatigue large enough to be the main cause of fatigue? Can. J. Physiol. Pharmacol. 64: 764-767, 1986.
395. RENAUD, J. M., R. B. STEIN, AND T. GORDON. The effects of pH on force and stiffness development in mouse muscles. Can. J. Physiol. Pharmacol. 65: 1798-1801, 1987.
396. RIOS, E., AND G. BRUM. Involvement of dihydropyridine receptors in excitation-contraction coupling in skeletal muscle. Nature Lond. 325: 717-720, 1987.
397. RIOS, E., J. MA, AND A. GONZALEZ. The mechanical hypothesis of excitation-contraction (EC) coupling in skeletal muscle. J. Muscle Res. Cell Motil. 12: 127-135, 1991.
398. RIOS, E., AND G. PIZARRO. Voltage sensors and calcium channels of excitation-contraction coupling. News Physiol. Sci. 3: 223-227, 1988.
399. RIOS, E., AND G. PIZARRO. The voltage sensor of excitation-contraction coupling in skeletal muscle. Physiol. Rev. 71: 849-908, 1991.
400. RIOS, E., G. PIZARRO, AND E. STEFANI. Charge movement and the nature of signal transduction in skeletal muscle excitation-contraction coupling. Annu. Rev. Physiol. 54: 109-133, 1992.
401. ROMIJN, J. A., AND R. R. WOLFE. Effects of prolonged exercise on endogenous substrate supply and utilization. In: Perspectives in Exercise Science and Sport Medicine. Energy Metabolism in Exercise and Sports, edited by D. R. Lamb and C. V. Gisolfi. Dubuque, IA: Brown & Benchmark, 1992, vol. 5, p. 207-234.
402. ROOS, A., AND W. F. BORON. Intracellular pH transients in rat diaphragm muscle measured with DMO. Am. J. Physiol. 235 (Cell Physiol. 4): C49-C54, 1978.
403. ROUSSEAU, E., AND J. PINKOS. pH modulates conducting and gating behavior of single calcium release channels. Pfluegers Arch. 415: 645-647, 1990.
404. SAHLIN, K. Intracellular pH and energy metabolism in skeletal muscle of man. Acta Physiol. Scand. Suppl. 455: 1-56, 1978.
405. SAHLIN, K. Effect of acidosis on energy metabolism and force generation in skeletal muscle. In: International Series on Sport Sciences. Biochemistry of Exercise, edited by H. G. Knuttgen, J. A. Vogel, and J. Poortmans. Champaign, IL: Human Kinetics, 1983, vol. 13, p. 151-160.
406. SAHLIN, K. Metabolic changes limiting muscle performance. In: International Series on Sport Sciences. Biochemistry of Exercise VI, edited by B. Saltin. Champaign, IL: Human Kinetics, 1986, vol. 16, p. 323-344.
407. SAHLIN, K. Muscle glucose metbolism during exercise. Ann. Med. 22: 185-189, 1990.
408. SAHLIN, K. Role of intracellular pH in fatigue. In: Muscle Fatigue: Biochemical and Physiological Aspects, edited by G. Atlan, L. Beliveau, and P. Bouissou. Paris: Masson, 1991, p. 27-39.
409. SAHLIN, K., A. ALVERSTRAND, R. BRANDT, AND E. HULTMAN. Intracellular pH and bicarbonate concentration in human muscle during recovery from exercise. J. Appl. Physiol. 45: 474-480, 1978.
410. + from muscle during prolonged dynamic exercise. Acta Physiol. Scand. 136: 293-294, 1989.
411. SAHLIN, K., AND S. BROBERG. Adenine nucleotide depletion in human muscle during exercise: causality and significance of AMP deamination. Int. J. Sports Med. 11, Suppl. 2: S62-S67, 1990.
412. SAHLIN, K., L. EDSTRÖM, AND H. SJÖHOLM. Fatigue and phosphocreatine depletion during carbon dioxide-induced acidosis in rat muscle. Am. J. Physiol. 245 (Cell Physiol. 14): C15-C20, 1983.
413. SAHLIN, K., L. EDSTRÖM, AND H. SJÖHOLM. Force, relaxation and energy metabolism of rat soleus muscle during anaerobic contraction. Acta Physiol. Scand. 129: 1-7, 1987.
414. SAHLIN, K., L. EDSTRÖM, H. SJOHÖLM, AND E. HULTMAN. Effects of lactic acid accumulation and ATP decrease on muscle tension and relaxation. Am. J. Physiol. 240 (Cell Physiol. 9): C121-C126, 1981.
415. SAHLIN, K., R. C. HARRIS, B. NYLIND, AND E. HULTMAN. Lactate content and pH in muscle samples obtained after dynamic exercise. Pfluegers Arch. 367: 143-149, 1976.
416. SAHLIN, K., A. KATZ, AND S. BROBERG. Tricarboxylic acid cycle intermediates in human muscle during prolonged exercise. Am. J. Physiol. 259 (Cell Physiol. 28): C834-C841, 1990.
417. SAHLIN, K., G. PALMSKOG, AND E. HULTMAN. Adenine nucleotide and IMP contents of the quadriceps muscle in man after exercise. Pfluegers Arch. 374: 193-198, 1978.
418. SAHLIN, K., AND J. M. REN. Relationship of contraction capacity to metabolic changes during recovery from a fatiguing contraction. J. Appl. Physiol. 67: 648-654, 1989.
419. SALTIN, B., AND B. ESSEN. Muscle glycogen, lactate, ATP, and CP in intermittent exercise. In: Advances in Experimental Medicine and Biology. Muscle Metabolism During Exercise, edited by B. Pernow and B. Saltin. New York: Plenum, 1971, vol. 11, p. 419-424.
420. SALTIN, B., AND J. KARLSSON. Muscle glycogen utilization during work of different intensities. In: Advances in Experimental Medicine and Biology. Muscle Metabolism During Exercise, edited by B. Pernow and B. Saltin. New York: Plenum, 1971, vol. 11, p. 289-299.
421. SALTIN, B., AND J. KARLSSON. Muscle ATP, CP, and lactate during exercise after physical conditioning. In: Advances in Experimental Medicine and Biology. Muscle Metabolism During Exercise, edited by B. Pernow and B. Saltin. New York: Plenum, 1971, vol. 11, p. 395-399.
422. SALTIN, B., J. WAHREN, AND B. PERNOW. Phosphagen and carbohydrate metbolism during exercise in trained middle-aged men. Scand. J. Clin. Lab. Invest. 33: 71-77, 1974.
423. SANDERCOCK, T. G., J. A. FAULKNER, J. W. ALBERS, AND P. H. ABBRECHT. Single motor unit and fiber action potentials during fatigue. J. Appl. Physiol. 58: 1073-1079, 1985.
424. SANDOW, A. Excitation-contraction coupling in muscular response. Yale J. Biol. Med. 25: 176-201, 1952.
425. SANDOW, A., AND M. BRUST. Effects of activity on contractions of normal and dystrophic mouse muscles. Am. J. Physiol. 202: 815-820, 1962.
426. SCHNEIDER, M. F., AND W. K. CHANDLER. Voltage dependent charge movement in skeletal muscle: a possible step in excitation-contraction coupling. Nature Lond. 242: 244-246, 1973.
427. SCHOTT, L. H., AND R. L. TERJUNG. The influence of exercise on muscle lysosomal enzymes. Eur. J. Appl. Physiol. 42:175-182, 1979.
428. SEJERSTED, O. M. Electrolyte imbalance in body fluids as a mechanism of fatigue during exercise. In: Perspectives in Exercise Science and Sport Medicine. Energy Metabolism in Exercise and Sports, edited by D. R. Lamb and C. V. Gisolfi. Dubuque, IA: Brown & Benchmark, 1992, vol. 5, p. 149-200.
429. SEJERSTED, O. M., AND J. HALLEN. Na,K homeostasis of skeletal muscle during activation. Med. Sport Sci. 26: 1-11, 1987.
430. SERAYDARIAN, M. W., B. C. ABBOTT, AND E. B. WILLIAMS. Studies on the frog's sartorius at different stages of activity. Biochim. Biophys. Acta 46: 355-363, 1961.
431. SHELVIN, H. H. Effects of external calcium concentration and pH on charge movement in frog skeletal muscle. J. Physiol. Lond. 288: 129-158, 1979.
432. SHERMAN, W. M., AND D. R. LAMB. Nutrition and prolonged exercise. In: Perspectives in Exercise Science and Sports Medicine. Prolonged Exercise, edited by D. R. Lamb and R. Murray. Indianapolis, IN: Benchmark, 1988, vol. 1, p. 213-280.
433. SIMONSON, E. Physiology of Work Capacity and Fatigue. Springfield, IL: Thomas, 1971.
434. SJØGAARD, G. Electrolytes in slow and fast muscle fibers of humans at rest and with dynamic exercise. Am. J. Physiol. 245 (Regulatory Integrative Comp. Physiol. 14)): R25-R31, 1983.
435. SJØGAARD, G. Water and electrolyte fluxes during exercise and their relation to muscle fatigue. Acta Physiol. Scand. 128, Suppl. 556: 129-136, 1986.
436. SJØGAARD, G. Muscle energy metabolism and electrolyte shifts during low-level prolonged static contraction in man. Acta Physiol. Scand. 134: 181-187, 1988.
437. SJØGAARD, G. Exercise-induced muscle fatigue: the significance of potassium. Acta Physiol. Scand. 140, Suppl. 593: 1-63, 1990.
438. SJØGAARD, G. Role of exercise-induced potassium fluxes underlying muscle fatigue: a brief review. Can. J. Physiol. Pharmacol. 69: 238-245, 1991.
439. SJØGAARD, G., R. P. ADAMS, AND B. SALTIN. Water and ion shifts in skeletal muscle of humans with intense dynamic knee extension. Am. J. Physiol. 248 (Regulatory Integrative Comp. Physiol. 17): R190-R196, 1985.
440. SJØGAARD, G., AND B. SALTIN. Extra- and intracellular water spaces in muscles of man at rest and with dynamic exercise. Am. J. Physiol. 243 (Regulatory Integrative Comp. Physiol. 12): R271-R280, 1982.
441. SJOSTRÖM, M., AND J. FRIDEN. Morphological studies of muscle fatigue. In: International Series on Sport Sciences. Biochemistry of Exercise, edited by H. G. Knuttgen, J. A. Vogel, and J. Poortmans. Champaign, IL: Human Kinetics, 1983, vol. 13, p. 161-171.
442. SÖDERLUND, K., AND E. HULTMAN. ATP content in single fibers from human skeletal muscle after electrical stimulation and during recovery. Acta Physiol. Scand. 139: 459-466, 1990.
443. SOMLYO, A. V., H. GONZALEZ-SERRATOS, G. MCCLELLAN, H. SHUMAN, L. M. BORRERO, AND A. P. SOMLYO. Electron probe analysis of the sarcoplasmic reticulum and vacuolated T-tubule system of fatigued frog muscles. Ann. NY Acad. Sci. 307: 232-234, 1978.
444. SPANDE, J. I., AND B. A. SCHOTTELIUS. Chemical basis of fatigue in isolated mouse soleus muscle. Am. J. Physiol. 219: 1490-1495, 1970.
445. SPENCER, M. K., Z. YAN, AND A. KATZ. Carbohydrate supplementation attenuates IMP accumulation in human muscle during prolonged exercise. Am. J. Physiol. 261 (Cell Physiol. 30): C71-C76, 1991.
446. SPRIET, L. L. Anaerobic ATP provision, glycogenolysis and glycolysis in rat slow-twitch muscle during tetanic contractions. Pfluegers Arch. 417: 278-284, 1990.
447. SPRIET, L. L. Phosphofructokinase activity and acidosis during short-term tetanic contractions. Can. J. Physiol. Pharmacol. 69: 298-304, 1991.
448. + concentration during maximal intermittent cycling. J. Appl. Physiol. 66: 8-13, 1989.
449. SPRIET, L. L., C. G. MATSOS, S. J. PETERS, G. J. F. HEIGENHAUSER, AND N. J. JONES. Effects of acidosis on rat muscle metabolism and performance during heavy exercise. Am. J. Physiol. 248 (Cell Physiol. 17): C337-C347, 1985.
450. SPRIET, L. L., K. SÖDERLUND, M. BERGSTRÖM, AND E. HULTMAN. Skeletal muscle glycogenolysis, glycolysis, and pH during electrical stimulation in men. J. Appl. Physiol. 62: 616-621, 1987.
451. SPRIET, L. L., M. SÖDERLUND, M. BERGSTRÖM, AND E. HULTMAN. Anaerobic energy release in skeletal muscle during electrical stimulation in men. J. Appl. Physiol. 62: 611-615, 1987.
452. SRETER, F. A. Cell water, sodium, and potassium in stimulated red and white mammalian muscles. Am. J. Physiol. 205: 1295-1298, 1963.
453. STAUBER, W. T. Eccentric action of muscles: physiology, injury, and adaptation. In: Exercise and Sport Sciences Reviews, edited by K. B. Pandolf. Baltimore, MD: Williams & Wilkins, 1989, vol. 17, p. 157-185.
454. STEPHENS, J. A., AND A. TAYLOR. Fatigue of maintained voluntary muscle contraction in man. J. Physiol. Lond. 220: 1-18, 1972.
455. STIENEN, G. J. M., M. C. M. ROOSEMALEN, M. B. A. WILSON, AND G. ELZINGA. Depression of force by phosphate in skinned skeletal muscle fibers of the frog. Am. J. Physiol. 259 (Cell Physiol. 28): C349-C357, 1990.
456. STIENEN, G. J. M., W. J. VAN DER LAARSE, AND G. ELZINGA. Dependency of the force-velocity relationship on MgATP in different types of muscle fibers from Xenopus laevis. Biophys. J. 53: 849-855, 1988.
457. 2+. J. Physiol. Lond. 451: 503-523, 1992.
458. STULL, G. A., AND D. H. CLARKE. Patterns of recovery following isometric and isotonic strength decrement. Med. Sci. Sports 3: 135-139, 1971.
459. TAKESHIMA, H., S. NISHIMURA, T. MATSUMOTO, H. ISHIDA, K. KANGAWA, N. MINAMINO, H. MATSUO, M. UEDA, M. HANAOKA, T. HIROSE, AND S. NUMA. Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor. Nature Lond. 339: 439-445, 1989.
460. TAYLOR, D. J., P. STYLES, P. M. MATTHEWS, D. A. ARNOLD, D. G. GADIAN, P. BORE, AND G. K. RADDA. Energetics of human muscle: exercise-induced ATP depletion. Magn. Reson. Med. 3: 44-54, 1986.
461. TAYLOR, S. R., AND R. RUDEL. Striated muscle fibers: inactivation of contraction induced by shortening. Science Wash. DC 167: 882-884, 1970.
462. TERJUNG, R. L., K. M. BALDWIN, P. A. MOLE, G. H. KLINKERFUSS, AND J. O. HOLLOSZY. Effect of running to exhaustion on skeletal muscle mitochondria: a biochemical study. Am. J. Physiol. 223: 549-554, 1972.
463. TERJUNG, R. L., G. A. DUDLEY, AND R. A. MEYER. Metabolic and circulatory limitations to muscular performance at the organ level. J. Exp. Biol. 115: 307-318, 1985.
464. TESCH, P. A., A. THORSSON, AND N. FUJITSUKA. Creatine phosphate in fiber types of skeletal muscle before and after exhaustive exercise. J. Appl. Physiol. 66: 1756-1759, 1989.
465. THOMASON, D. B., K. M. BALDWIN, AND R. E. HERRICK. Myosin isozyme distribution in rodent hindlimb skeletal muscle. J. Appl. Physiol. 60: 1923-1931, 1986.
466. THOMPSON, L. V., E. M. BALOG, AND R. H. FITTS. Muscle fatigue in frog semitendinosus: role of intracellular pH. Am. J. PhysioL 262 (Cell Physiol. 31): C1507-C1512, 1992.
467. THOMPSON, L. V., E. M. BALOG, D. A. RILEY, AND R. H. FITTS. Muscle fatigue in frog semitendinosus: alterations in contractile function. Am. J. Physiol. 262 (Cell Physiol. 31): C1500-C1506, 1992.
468. i. Am. J. Physiol. 263 (Cell Physiol. 32): C803-C809, 1992.
469. THORSTENSSON, A., AND J. KARLSSON. Fatiguability and fiber composition of human skeletal muscle. Acta Physiol. Scand. 98: 318-322, 1976.
470. TRIVEDI, B., AND W. H. DANFORTH. Effect of pH on the kinetics of frog muscle phosphofructokinase. J. Biol. Chem. 241: 4110-4112, 1966.
471. TROUP, J. P., J. M. METZGER, AND R. H. FITTS. Effect of highintensity exercise training on functional capacity of limb skeletal muscle. J. Appl. Physiol. 60: 1743-1751, 1986.
472. VAN BEAUMONT, W., J. C. STRAND, J. S. PETROSFSKY, S. G. HIPSKIND, AND J. E. GREENLEAF. Changes in total plasma content of electrolytes and proteins with maximal exercise. J. Appl. Physiol. 34: 102-106, 1973.
473. VERGARA, J., R. Y. TSIEN, AND M. DELAY. Inositol [1,4,5]-triphosphate: a possible chemical link in excitation-contraction coupling in muscle. Proc. Natl. Acad. Sci. USA 82: 6352-6356, 1985.
474. VERGARA, J. L., S. I. RAPOPORT, AND V. NASSAR-GENTIA. Fatigue and posttetanic potentiation in single muscle fibers of the frog. Am. J. Physiol. 232 (Cell Physiol. 1): C185-C190, 1977.
475. VIHKO, V., A. SALMINEN, AND J. RANTAMÄKI. Acid hydrolase activity in red and white skeletal muscle of mice during a two-week period following exhausting exercise. Pfluegers Arch. 378: 99-106, 1978.
476. VOLPE, P., G. SALVIATI, F. DIVIRGILIO, AND T. POZZAN. Inositol [1,4,5]-trisphosphate induces calcium release from sarcoplasmic reticulum of skeletal muscle. Nature Lond. 316: 347-349, 1985.
477. + concentration changes in human muscles during volitional contractions. Pfluegers Arch. 399: 235-237, 1983.
478. WAGENMAKERS, A. J. M., E. J. BECKERS, F. BROUNS, H. KUIPERS, P. B. SOETERS, G. J. VAN DER VUSSE, AND W. H. M. SARIS. Carbohydrate supplementation, glycogen depletion, and amino acid metabolism during exercise. Am. J. Physiol. 260 (Endocrinol. Metab. 23): E883-E890, 1991.
479. WAHREN, J., G. AHLBORG, P. FELIG, AND L. JORFELDT. Glucose metabolism during exercise in man. In: Advances in Experimental Medicine and Biology. Muscle Metabolism During Exercise, edited by B. Saltin and B. Pernow. New York: Plenum, 1971, vol. 11, p. 189-203.
480. WAHREN, J., P. FELIG, G. AHLBORG, AND L. JORFELDT. Glucose metabolism during leg exercise in man. J. Clin. Invest. 50: 2715-2725, 1971.
481. WALKER, J. W., Z. LU, AND R. L. MOSS. Effects of Ca on the kinetics of phosphate release in skeletal muscle. J. Biol Chem. 267: 2459-2466, 1992.
482. WEINER, M. W., R. S. MOUSSAVI, A. J. BAKER, M. D. BOSKA, AND R. G. MILLER. Constant relationships between force, phosphate concentration, and pH in muscles with differential fatigability. Neurology 40: 1888-1893, 1990.
483. WESTERBLAD, H., AND D. G. ALLEN. Changes of myoplasmic calcium concentration during fatigue in single mouse muscle fibers. J. Gen. Physiol. 98: 615-635, 1991.
484. WESTERBLAD, H., AND D. G. ALLEN. Changes of intracellular pH due to repetitive stimulation of single fibers from mouse skeletal muscle. J. Physiol. Lond. 449: 49-71, 1992.
485. 2+ concentration during repetitive stimulation of single fibers from mouse skeletal muscle. J. Physiol. Lond. 453: 413-434, 1992.
486. WESTERBLAD, H., AND J. LÄNNERGREN. Force and membrane potential during and after fatiguing, intermittent tetanic stimulation of single Xenopus muscle fibers. Acta Physiol. Scand. 128: 369-378, 1986.
487. WESTERBLAD, H., AND J. LANNERGREN. The relation between force and intracellular pH in fatigued, single Xenopus muscle fibers. Acta Physiol. Scand. 133: 83-89, 1988.
488. WESTERBLAD, H., AND J. LÄNNERGREN. Slowing of relaxation during fatigue in single mouse muscle fibers. J. Physiol. Lond. 434: 323-336, 1991.
489. WESTERBLAD, H., J. A. LEE, J. A. LAMB, S. R. BOLSOVER, AND D. G. ALLEN. Spatial gradients of intracellular calcium in skeletal muscle during fatigue. Pfluegers Arch. 415: 734-740, 1990.
490. WESTERBLAD, H., J. A. LEE, J. LANNERGREN, AND D. G. ALLEN. Cellular mechanisms of fatigue in skeletal muscle. Am. J. Physiol. 261 (Cell Physiol. 30): C195-C209, 1991.
491. WESTRA, H. G., A. DE HAAN, E. VAN DOORN, AND E. J. DE HAAN. IMP production and energy metabolism during exercise in rats in relation to age. Biochem. J. 239: 751-755, 1986.
492. WHITLOCK, D. M., AND R. L. TERJUNG. ATP depletion in slowtwitch red muscle of rat. Am. J. Physiol. 253 (Cell Physiol. 22): C426-C432, 1987.
493. WILKIE, D. R. Muscular fatigue: effects of hydrogen ions and inorganic phosphate. Federation Proc. 45: 2921-2923, 1986.
494. 31P-NMR study. J. Appl. Physiol. 64: 2333-2339, 1988.
495. WOODS, J. J., F. FURBISH, AND B. R. BIGLAND-RITCHIE. Evidence for a fatigue-induced reflex inhibition of motor neuron firing rates. J. Neurophysiol. 58: 125-137, 1987.
496. ZERBA, E., T. E. KOMOROWSKI, AND J. A. FAULKNER. Free radical injury to skeletal muscles of young, adult, and old mice. Am. J. Physiol. 258 (Cell Physiol. 27): C429-C435, 1990.