Characterization and morphological analysis of protein-loaded poly(lactide-co-glycolide) microparticles prepared by water-in-oil-in-water emulsion technique

Journal of Controlled Release

Volumn 32, Issue 3, 1994, Pages 231-241

  Yan, Changhong ^a   Resau, James H ^b   Hewetson, John ^a   West, Michael ^a   Rill, Wayne L ^a   Kende, Meir ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Confocal laser scan microscope; Microencapsulation; Poly(lactide co glycolide), Vaccine

Indexed keywords

BOVINE SERUM ALBUMIN; FLUORESCEIN ISOTHIOCYANATE; MICROSPHERE; POLYACRYLAMIDE; POLYGLACTIN; POLYLACTIC ACID; POLYMER; POLYVINYL ALCOHOL; PROTEIN; RICIN;

ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG RELEASE; EMULSION; LASER MICROSCOPY; MICROENCAPSULATION; PARTICLE SIZE; PHARMACEUTICS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TECHNIQUE;

EID: 0028105002     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(94)90233-X     Document Type: Article

References (23)

1. Controlled release microparticles for vaccine development
2. Biodegradable micro spheres as a vaccine delivery system
3. Biodegradable microparticles for oral immunization
4. Controlled vaccine release in the gut-associated lymphoid tissues. 1. Orally administered biodegradable microspheres target the peyer's patches
5. Immunization of rabbits with enterotoxigenic E. coli colonization factor antigen (CFA/I) encapsulated in biodegradable microspheres of poly(lactide-co-glycolide)
6. Opportunities and challenges in the design of implantable biodegradable polymeric systems for the delivery of antimicrobial agents and vaccines
7. Future approaches to vaccine development: Single-dose vaccine using controlled-release delivery systems
8. Poly(lactic acid) microencapsulated oxytetracycline: in vitro and in vivo evaluation
9. Microencapsulation using poly(L-lactic acid) I: Microcapsule properties affected by the preparative technique
10. A new technique to efficiently entrap leuprolide cetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid
11. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres
12. The preparation and characterization of poly(lactide-co-glycolide) microparticles. II. The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique
13. Controlled release of tetanus toxoid from poly(lactic/glycolic acid) microspheres
14. The met proto-oncogene receptor and lumen formation
15. Cleavage of structural proteins during the assembly of the head of the bacteriophage T4
16. Microencapsulation
17. Microencapsulation by solvent evaporation and organic phase separation processes
18. Intestinal translocation of particulates-implications for drug and antigen delivery
19. Carrier-mediated delivery of antiviral agents
20. Degradation of poly(lactic acid) polymer and copolymer of poly(glycolic acid)
21. Biodegradable polymers in sustained release of polypeptides
22. Dependence of vaccine efficacy on carrier structure