Homeodomain-DNA recognition

Cell

Volumn 78, Issue 2, 1994, Pages 211-223

  Gehring, Walter J ^a   Qian, Yan Qiu ^b   Billeter, Martin ^b   Furukubo Tokunaga, Katsuo ^a   Schier, Alexander F ^a   Resendez Perez, Diana ^a   Affolter, Markus ^a   Otting, Gottfried ^b   Wüthrich, Kurt ^b  

^a UNIVERSITY OF BASEL   (Switzerland)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; HOMEODOMAIN PROTEIN; REGULATOR PROTEIN; TRANSCRIPTION FACTOR;

AMINO ACID ANALYSIS; DNA BINDING; DROSOPHILA; GENE CONTROL; GENE STRUCTURE; GENE TARGETING; HOMEOBOX; PRIORITY JOURNAL; REGULATOR GENE; REVIEW; TRANSCRIPTION REGULATION;

EID: 0028103855     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90292-5     Document Type: Review

References (75)

1. DNA binding properties of the purified Antennapedia homeodomain
2. Similarities between the homeodomain and the Hin recombinase DNA-binding domain
3. Identification, purification, and cloning of a polypeptide (PRTF/GRM) that binds to mating-specific promoter elements in yeast
4. 1H nuclear magnetic resonance spectroscopy
5. Determination of the NMR solution structure of an Antennapedia homeodomain-DNA complex
6. Appendix: model studies relating nuclear magnetic resonance data with the three-dimensional structure of protein-DNA complexes
7. The X-ray structure of an atypical homeodomain present in the rat liver transcription factor LFB1/HNF1 and implications for DNA binding
8. The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxyterminal sequences
9. Transcriptional regulation of liver-specific gene expression
10. Binding of yeast a1 and α2 as a heterodimer to the operator DNA of a haploid-specific gene
11. The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo
12. Hin recombinase bound to DNA: the origin of specificity in major and minor groove interactions
13. In vivo analysis of the helix-turn-helix motif of the fushi tarazu homeo domain of Drosophila melanogaster
14. Functional specificity of the Antennapedia homeodomain
15. Homeo boxes in the study of development
16. The structure of the homeodomain and its functional implications
17. Homeodomain proteins
18. The specificites of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain
19. Yeast a1 and α2 homeodomain proteins form a DNA-binding activity with properties distinct from those of either protein
20. Structure determination of the Antp(C39←S) homeodomain from nuclear magnetic resonance data in solution using a novel strategy for the programs DIANA, CALIBA, HABAS, and GLOMSA
21. DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9
22. A genetic model for interaction of the homeodomain recognition helix with DNA
23. Regulation and function of the Drosophila segmentation gene fushi tarazu
24. Binding of a Drosophila POU domain protein to a sequence element regulating gene expression in specific dopminergic neurons
25. A combinatorial regulatory circuit in budding yeast
26. A universal sequence is bound in vitro by diverse homeodomains
27. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL
28. Variable effects of phosphorylation of Pit-1 dictated by the DNA response elements
29. The yeast cell-type-specific repressor α2 acts cooperatively with a non-cell-type-specific protein
30. Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: a framework for understanding homeodomain-DNA interactions
31. Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules
32. Understanding the homeodomain
33. DNA binding specificity of homeodomains
34. The three-dimensional NMR-solution structure of the polypeptide fragment 195–286 of the LFB1/HNF1 transcription factor from rat liver comprises a non-classical homeodomain
35. Mapping functional specificity in the Dfd and Ubx homeo domains
36. Functional dissection of Ultrabithorax proteins in Drosophila melanogaster
37. Homeobox genes and axial patterning
38. HNF-1, a member of a novel class of dimerizing homeodomain proteins
39. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1
40. Isolation and sequence-specific DNA binding of the Antennapedia homeodomain
41. Chromosomal translocation t(1;19) results in the synthesis of a homeobox fusion mRNA that codes for the potential chimeric transcription factor
42. Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution
43. Proton exchange with internal water molecules in the protein BPTI in aqueous solution
44. Crystal structure of trp repressor/operator complex at atomic resolution
45. Transcription factors: structural families and principles of DNA recognition
46. A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes
47. Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity
48. The interaction with DNA of wild-type and mutant fushi tarazu homeodomains
49. Analysis of the ftz upstream element: germ layer-specific enhancers are independently autoregulated
50. The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: comparison with prokaryotic repressors
51. NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein
52. 13C-labeled Antennapedia homeodomain and structure determination of the DNA-bound homeodomain
53. NMR detection of hydration water in the intermolecular interface of a protein-DNA complex
54. Nuclear magnetic resonance solution structure of the fushi tarazu homeodomain from Drosophila and comparison with the Antennapedia homeodomain
55. The des(1–6) Antennapedia homeodomain: comparison of the NMR solution structure and the DNA binding affinity with the intact Antennapedia homeodomain
56. extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1
57. Direct homeodomain-DNA interaction in the autoregulation of the fushi tarazu gene
58. Functional specificity of the homeodomain protein fushi tarazu: the role of DNA binding specificity in vivo
59. Analysis of a fushi tarazu autoregulatory element: multiple sequence elements contribute to enhancer activity
60. The b alleles of U. maydis, whose combinations program pathogenic development, code for poly-peptides containing a homeodomain-related motif
61. The structure and function of the homeodomain
62. Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity
63. Determinants of repressor/operator recognition from the structure of the trp operator binding site
64. Synthesis of a sequence-specific DNA-cleaving peptide
65. Importance of minor-groove contacts for recognition of DNA by the binding domain of Hin recombinase
66. Structural studies of protein-nucleic acid interaction: the sources of sequence-specific binding
67. Common features in DNA recognition helices of eukaryotic transcription factors
68. I-POU: a POU domain protein that inhibits neuron-specific gene activation
69. Twin of I-POU: a two amino acid difference in the I-POU homeodomain distinguishes an activator from an inhibitor of transcription
70. A single amino acid can determine the DNA binding specificity of homeodomain proteins
71. A short, disordered protein region mediates interactions between the homeodomain of the yeast α2 protein and the MCM1 protein
72. Specificity of embryonic lethal mutations in Drosophila analysed in germ line clones
73. Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions
74. Transcriptional regulation by homeodomain proteins: structural, functional, and genetic aspects
75. Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity