The Effect of the Aromatic Rings of Taxol on Biological Activity and Solution Conformation: Synthesis and Evaluation of Saturated Taxol and Taxotere Analogues

Journal of Medicinal Chemistry

Volumn 37, Issue 20, 1994, Pages 3337-3343

  Boge, Thomas C ^a   Himes, Richard H ^a,b   Vander Velde, David G ^a   Georg, Gunda I ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b Departments of Biochemistry   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (CYCLOHEXYLCARBONYL) 2 DEBENZOYLBACCATIN III; 2 (CYCLOHEXYLCARBONYL) 2 DEBENZOYLTAXOTERE; 2 O (CYCLOHEXYLCARBONYL) 2 DEBENZOYLBACCATIN III 13 O [N (CYCLOHEXYLCARBONYL) 3 CYCLOHEXYLISOSERINATE]; 3' CYCLOHEXYL 3' DEPHENYLTAXOL; DOCETAXEL; N BENZOYL 3 [(TERT BUTYLDIMETHYLSILYL)OXY] 4 CYCLOHEXYL 2 AZETIDINONE; PACLITAXEL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; CYTOTOXICITY; DRUG CONFORMATION; DRUG SYNTHESIS; MELANOMA CELL; MICROTUBULE ASSEMBLY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CHLOROFORM; COMPARATIVE STUDY; DIMETHYL SULFOXIDE; MELANOMA, EXPERIMENTAL; MICROTUBULES; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PACLITAXEL; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028097492     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00046a018     Document Type: Article

References (46)

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