Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates

American Journal of Psychiatry

Volumn 151, Issue 10, 1994, Pages 1485-1491

  Mehlman, P T ^a   Higley, J D ^b   Faucher, I ^b   Lilly, A A ^b   Taub, D M ^b   Vickers, J ^b   Suomi, S J ^b   Linnoila, M ^b  

^a LABS ^*  (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; 5 HYDROXYINDOLEACETIC ACID; CORTICOTROPIN; HOMOVANILLIC ACID; HYDROCORTISONE; NORADRENALIN; SEROTONIN; TESTOSTERONE;

ADOLESCENT; AGGRESSIVENESS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CEREBROSPINAL FLUID LEVEL; IMPULSIVENESS; JUMPING; MACACA; MALE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; SELF CONTROL; WOUND;

EID: 0028092848     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.151.10.1485     Document Type: Article

References (80)

1. Brown GL, Goodwin FK, Ballenger JC, Goyer PF, Major LF: Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res 1979; 1:131-139
2. Brown GL, Goodwin FK, Bunney WEJ: Human aggression and suicide: their relationship to neuropsychiatric diagnoses and serotonin metabolism. Adv Biochem Psychopharmacol 1982; 34: 287-307
3. Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimon R, Goodwin FK: Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci 1983; 33:2609-2614
4. Virkkunen M, Nuutila A, Goodwin FK, Linnoila M: Cerebrospinal fluid monoamine metabolite levels in male arsonists. Arch Gen Psychiatry 1987; 44:241-217
5. Brown GL, Ebert MH, Goyer PF, Jimerson DC, Klein WJ, Bunney WE, Goodwin FK: Aggression, suicide, and serotonin: relationships to CSF amine metabolites. Am J Psychiatry 1982; 139: 741-746
6. Lidberg L, Tuck JR, Åsberg M, Scalia-Tomba GP, Bertilsson L: Homicide, suicide and CSF 5-HIAA. Acta Psychiatr Scand 1985; 71:230-236
7. Limson R, Goldman D, Roy A, Lamparski D, Ravitz B, Adinoff B, Linnoila M: Personality and cerebrospinal fluid monoamine metabolites in alcoholics and controls. Arch Gen Psychiatry 1991; 48:437-441
8. Virkkunen M, Rawlings R, Tokola R, Poland RE, Guidotti A, Neveroff C, Bissette G, Kalogeras K, Karonen SL, Linnoila M: CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiatry 1994; 51:20-27
9. Virkkunen M, Kallio E, Rawlings R, Tokola R, Poland RE, Guidotti A, Nemeroff C, Bissette G, Kalogeras K, Karonen SL, Linnoila M: Personality profiles and state aggressiveness in Finnish alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiatry 1994; 51:28-33
10. Ballenger JC, Goodwin FK, Major LF, Brown GL: Alcohol and central serotonin metabolism in man. Arch Gen Psychiatry 1979; 36:224-227
11. Banki CM: Factors influencing monoamine metabolites and tryptophan in patients with alcohol dependence. J Neural Transm 1981; 50:89-101
12. Borg S, Kvande H, Liljeberg P, Mossberg D, Valverius P: 5-Hydroxyindoleacetic acid in cerebrospinal fluid in alcoholic patients under different clinical conditions. Alcohol 1985; 2:415-418
13. Moss HB: Serotonergic activity and disinhibitory psychopathy in alcoholism. Med Hypotheses 1987; 23:353-361
14. Roy A, Linnoila M: CSF studies on alcoholism and related behaviours. Prog Neuropsychopharmacol Biol Psychiatry 1989; 13:505-511
15. Butler IJ, Koslow SH, Seifert WEJ, Caprioli RM, Singer HS: Biogenic amine metabolism in Tourette syndrome. Ann Neurol 1979; 6:37-39
16. Cohen DJ, Shaywitz BA, Caparulo B, Young JG, Bowers MBJ: Chronic, multiple tics of Gilles de la Tourette's disease: CSF acid monoamine metabolites after probenecid administration. Arch Gen Psychiatry 1978; 35:245-250
17. Cohen DJ, Shaywitz BA, Young JG, Carbonari CM, Nathanson JA, Lieberman D, Bowers MBJ, Maas JW: Central biogenic amine metabolism in children with the syndrome of chronic multiple tics of Gilles de la Tourette: norepinephrine, serotonin, and dopamine. J Am Acad Child Psychiatry 1979; 18:320-341
18. Jimerson DC, Lesem MD, Kaye WH, Hegg AP, Brewerton TD: Eating disorders and depression: is there a serotonin connection? Biol Psychiatry 1990; 28:443-454
19. Jimerson DC, Lesem MD, Kaye WH, Brewerton TD: Low serotonin and dopamine metabolite concentrations in cerebrospinal fluid from bulimic patients with frequent binge episodes. Arch Gen Psychiatry 1992; 49:132-138
20. Åsberg M, Träskman L, Thorén P: 5-HIAA in the cerebrospinal fluid: a biochemical suicide predictor. Arch Gen Psychiatry 1976; 33:1193-1197
21. Åsberg M, Nordstrom P, Traskman-Bendz L: Cerebrospinal fluid studies in suicide: an overview. Ann NY Acad Sci 1986; 487:243-255
22. Banki CM, Arato M: Amine metabolites, neuroendocrine findings, and personality dimensions as correlates of suicidal behavior. Psychiatry Res 1983; 10:253-261
23. Kruesi MJ, Rapoport JL, Hamburger S, Hibbs E, Potter WZ, Lenane M, Brown GL: Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Arch Gen Psychiatry 1990; 47:419-426
24. Kruesi MJ: Cruelty to animals and CSF 5HIAA (letter). Psychiatry Res 1989; 28:115-116
25. Kruesi MJ, Hibbs ED, Zahn TP, Keysor CS, Hamburger SD, Bartko JJ, Rapoport JL: A 2-year prospective follow-up study of children and adolescents with disruptive behavior disorders: prediction by cerebrospinal fluid 5-hydroxyindoleacetic acid, homovanillic acid, and autonomie measures? Arch Gen Psychiatry 1992; 49:429-435
26. Naumenko EV, Popova NK, Nikulina EM, Dygalo NN, Shishkina GT, Borodin PM, Markel AL: Behavior, adrenocortical activity, and brain monoamines in Norway rats selected for reduced aggressiveness towards man. Pharmacol Biochem Behav 1989; 33:85-91
27. Popova NK, Kulikov AV, Nikulina EM, Kozlachkova EY, Maslova GB: Serotonin metabolism and serotonergic receptors in Norway rats selected for low aggressiveness towards man. Aggressive Behavior 1991; 17:207-213
28. Popova NK, Voitenko NN, Kulikov AV, Avgustinovich DF: Evidence for the involvement of central serotonin in mechanism of domestication of silver foxes. Pharmacol Biochem Behav 1991; 40:751-756
29. Miczek KA, Donat P: Brain 5-HT system and inhibition of aggressive behavior, in Behavioral Pharmacology of 5-HT. Edited by Archer T, Bevan P, Cools A, Hillsdale, NJ, Lawrence Erlbaum Associates, 1990
30. Nikulina EM, Avgustinovich DF, Popova NK: Role of 5HT1A receptors in a variety of kinds of aggressive behavior in wild rats and counterparts selected for low defensiveness to man. Aggressive Behavior 1992; 18:357-364
31. Olivier B, Mos J, Tulp M, Schipper J, Bevan P: Modulatory action of serotonin in aggressive behavior, in Behavioral Pharmacology of 5-HT. Edited by Archer T, Bevan P, Cools A. Hillsdale, NJ, Lawrence Erlbaum Associates, 1990
32. Olivier B, Mos J: Serenics, serotonin and aggression. Prog Clin Biol Res 1990; 361:203-230
33. Chamberlain B, Ervin FR, Pihl RO, Young SN: The effects of raising or lowering tryptophan levels on aggression in vervet monkeys. Pharmacol Biochem Behav 1987; 28:503-510
34. Raleigh MJ, Brammer GL, McGuire MT, Yuwiler A: Dominant social status facilitates the behavioral effects of serotonergic agonists. Brain Res 1985; 348:274-282
35. Raleigh MJ, McGuire MT, Brammer GL, Pollack DB, Yuwiler A: Serotonergic mechanisms promote dominance acquisition in adult male vervet monkeys. Brain Res 1991; 559:181-190
36. Raleigh MJ, McGuire MT: Animal analogues of ostracism: Biological mechanisms and social consequences. Ethology and Sociobiology 1986; 7:53-66
37. Raleigh MJ, Brammer GL, McGuire MT: Male dominance, serotonergic systems, and the behavioral and physiological effects of drugs in vervet monkeys (Cercopithecus aethiops sabaeus). Prog Clin Biol Res 1983; 131:185-197
38. Raleigh MJ, Brammer GL, Ritvo ER, Geller E, McGuire MT, Yuwiler A: Effects of chronic fenfluramine on blood serotonin, cerebrospinal fluid metabolites, and behavior in monkeys. Psychopharmacology (Berl) 1986; 90:503-508
39. Raleigh MJ, Brammer GL, Yuwiler A, Flannery JW, McGuire MT: Serotonergic influences on the social behavior of vervet monkeys (Cercopithecus aethiops sabaeus). Exp Neurol 1980; 68:322-334
40. Gleeson S, Ahlers ST, Mansbach RS, Foust JM, Barrett JE: Behavioral studies with anxiolytic drugs, VI: effects on punished responding of drugs interacting with serotonin receptor subtypes. J Pharmacol Exp Ther 1989; 250:809-817
41. Miczek KA, Mos J, Olivier B: Brain 5-HT and inhibition of aggressive behavior in animals: 5-HIAA and receptor subtypes. Psychopharmacol Bull 1989; 25:399-403
42. Soubrié P: Reconciling the role of central serotonin neurons in human and animal behavior. Behav Brain Sci 1986; 9:319-364
43. Gill K, Amit Z: Serotonin uptake blockers and voluntary alcohol consumption: a review of recent studies. Recent Dev Alcohol 1989; 7:225-48
44. McBride WJ, Murphy JM, Lumeng L, Li TK: Serotonin and ethanol preference. Recent Dev Alcohol 1989; 7:187-209
45. Higley JD, Suomi SJ, Linnoila M: CSF monoamine metabolite concentrations vary according to age, rearing, and sex, and are influenced by the stressor of social separation in rhesus monkeys. Psychopharmacology (Berl) 1991; 103:551-556
46. Bertilsson L, Åsberg M, Lantto O, Scalia-Tomba GP, Träskman-Bendz L, Tybring G: Gradients of monoamine metabolites and cortisol in cerebrospinal fluid of psychiatric patients and healthy controls. Psychiatry Res 1982; 6:77-83
47. Cohen DJ, Shaywitz BA, Johnson WT, Bowers MD: Biogenic amines in autistic and atypical children. Arch Gen Psychiatry 1974; 31:845-853
48. Higley JD, Suomi SJ, Linnoila M: A longitudinal assessment of CSF monoamine metabolite and plasma cortisol concentrations in young rhesus monkeys. Biol Psychiatry 1992; 32:127-145
49. Kraemer GW, Ebert MH, Schmidt DE, McKinney WT: A longitudinal study of the effect of different social rearing conditions on cerebrospinal fluid norepinephrine and biogenic amine metabolites in rhesus monkeys. Neuropsychopharmacology 1989; 2:175-189
50. Riddle MA, Anderson GM, McIntosh S, Harcherik DF, Shaywitz BA, Cohen DJ: Cerebrospinal fluid monoamine precursor and metabolite levels in children treated for leukemia: age and sex effects and individual variability. Biol Psychiatry 1986; 21:69-83
51. Träskman-Bendz L, Åsberg M, Bertilsson L, Thoren P: CSF monoamine metabolites of depressed patients during illness and after recovery. Acta Psychiatr Scand (Suppl) 1984; 69:333-342
52. Higley JD, Thompson WT, Champoux M, Goldman D, Hasert MF, Kraemer GW, Suomi SJ, Linnoila M: Paternal and maternal genetic and environmental contributions to CSF monoamine metabolite concentrations in rhesus monkeys (Macaca mulatta). Arch Gen Psychiatry 1993; 50:615-623
53. Oxenstierna G, Edman G, Iselius L, Oreland L, Ross SB, Sedvall G: Concentrations of monoamine metabolites in the cerebrospinal fluid of twins and unrelated individuals - a genetic study. J Psychiatr Res 1986; 20:19-29
54. Cloninger CR: A unified biosocial theory of personality and its role in the development of anxiety states. Psychiatr Dev 1986; 3:167-226
55. Spoont MR: Modulatory role of serotonin in neural information processing: implications for human psychopathology. Psychol Bull 1987; 112:330-350
56. Koop BF, Tagle DA, Goodman M, Slightom JL: A molecular view of primate phylogeny and important systematic and evolutionary questions. Mol Biol Evol 1989; 6:580-612
57. Kohne DE: DNA evolution data and its relevance to mammalian phylogeny, in Phylogeny of the Primates: A Multidisciplinary Approach. Edited by Luckett WP, Szalay FS. New York, Plenum, 1975
58. Goodman M, Lasker GW: Molecular evidence as to man's place in nature, in Primate Functional Morphology and Evolution. Edited by Turtle RH. Chicago, Aldine, 1975
59. Sarich V: A molecular approach to the question of human origins, in Primate Evolution and Human Origins. Edited by Ciochon RL, Fleagle JG. Menlo Park, Calif, Benjamin/Cummings, 1985
60. Sibley CG, Ahlquist JE: DNA hybridization evidence of hominoid phylogeny: results from an expanded data set. J Mol Evol 1987; 26:99-121
61. Sibley CG, Corastock JA, Ahlquist JE: DNA hybridization evidence of hominoid phylogeny: a reanalysis of the data. J Mol Evol 1990; 30:202-236
62. Ciochon RL, Fleagle JG: Primate Evolution and Human Origins. Menlo Park, Calif, Benjamin/Cummings, 1985
63. Fleagle JG: Primate Adaptation and Evolution. New York, Academic Press, 1988
64. King FA, Yarbrough CJ, Anderson DC, Gordon TP, Gould KG: Primates. Science 1988; 240:1475-1482
65. Bernstein IS, Williams L, Ramsay M: The expression of aggression in Old World monkeys. Int J Primatol 1983; 4:113-125
66. Hall KRL: Aggression in monkey and ape societies, in Primates: Studies in Adaptation and Variability. Edited by Jay PC. New York, Holt, Rinehart and Winston, 1968
67. Washburn SL, Hamburg DA: Aggressive behavior in old world monkeys and apes. Ibid
68. Yodyingyuad U, de la Riva C, Abbott DH, Herbert J, Keverne EB: Relationship between dominance hierarchy, cerebrospinal fluid levels of amine transmitter metabolites (5-hydroxyindole acetic acid and homovanillic acid) and plasma cortisol in monkeys. Neuroscience 1985; 16:851-858
69. Higley JD, Mehlman P, Taub D, Higley SB, Vickers JH, Suomi SJ, Linnoila M: Cerebrospinal fluid monoamine and adrenal correlates of aggression in free-ranging rhesus monkeys. Arch Gen Psychiatry 1992; 49:436-441
70. Apter A, van Praag PH, Plutchik R, Sevy S, Korn M, Brown SL: Interrelationships among anxiety, aggression, impulsivity, and mood: a serotonergically linked cluster? Psychiatry Res 1990; 32:191-199
71. Linnoila M, Dejong J, Virkkunen M: Family history of alcoholism in violent offenders and impulsive fire setters. Arch Gen Psychiatry 1989; 46:613-616
72. Virkkunen M, De Jong J, Bartko J, Linnoila M: Psychobiological concomitants of history of suicide attempts among violent offenders and impulsive fire setters. Arch Gen Psychiatry 1989; 46:604-606
73. Virkkunen M, De Jong J, Bartko J, Goodwin FK, Linnoila M: Relationship of psychobiological variables to recidivism in violent offenders and impulsive fire setters: a follow-up study. Arch Gen Psychiatry 1989; 46:600-603
74. Virkkunen M, Linnoila M: Serotonin in early onset, male alcoholics with violent behaviour. Ann Med 1990; 22:327-331
75. Scheinin M, Chang WH, Kirk KL, Linnoila M: Simultaneous determination of 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, and homovanillic acid in cerebrospinal fluid with high-performance liquid chromatography using electrochemical detection. Anal Biochem 1983; 131:246-253
76. Abraham GE, Buster JE, Teller RC: Radioimmunoassay of plasma cortisol. Analytical Letters 1972; 5:757-766
77. Altmann SA: A field study of the sociobiology of rhesus monkeys, Macaca mulatta. Ann NY Acad Sci 1962; 102:338-435
78. van Hooff JA: The facial displays of the catarrhine monkeys and apes, in Primate Ethology. Edited by Morris D. London, Weidenfield and Nicolson, 1967
79. Plant TM: A study of the role of the postnatal testes in determining the ontogeny of gonadotropin secretion in the male rhesus monkey (Macaca mulatta). Endocrinology 1985; 116:1341-1349
80. Agren H, Mefford IN, Rudorfer MV, Linnoila M, Potter WZ: Interacting neurotransmitter systems: a non-experimental approach to the 5-HIAA-HVA correlation in human CSF. Psychiatry Res 1986; 20:175-193