Self-Immolative Prodrugs: Candidates for Antibody-Directed Enzyme Prodrug Therapy in Conjunction with a Nitroreductase Enzyme

Journal of Medicinal Chemistry

Volumn 37, Issue 21, 1994, Pages 3452-3458

  Mauger, Anthony B ^a   Somani, Hanif H ^a   Friedlos, Frank ^a   Knox, Richard J ^a   Burke, Philip J ^b  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 [BIS(2 CHLOROETHYL)AMINO]ANILINE; 4 [BIS(2 CHLOROETHYL)AMINO]PHENOL; 5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; ANTINEOPLASTIC AGENT; ARACHIS OIL; BENZOIC ACID NITROGEN MUSTARD GLUTAMATE; CANCER ANTIBODY; CARBOXYPEPTIDASE G2; CHLORMETHINE DERIVATIVE; DACTINOMYCIN; DOXORUBICIN; MITOMYCIN D; NITROREDUCTASE; PRODRUG; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY LABELING; ARTICLE; CANCER CHEMOTHERAPY; CHINESE HAMSTER; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVATION; DRUG DESIGN; DRUG SYNTHESIS; DRUG TARGETING; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN;

ANIMAL; ANTINEOPLASTIC AGENTS; COMPARATIVE STUDY; DACTINOMYCIN; IMMUNOTOXINS; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; NITROREDUCTASES; PRODRUGS; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0028090161     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00047a002     Document Type: Article

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