Transdermal clonidine for ameliorating tamoxifen-induced hot flashes

Journal of Clinical Oncology

Volumn 12, Issue 1, 1994, Pages 155-158

  Goldberg, Richard M ^b   Loprinzi, Charles L ^a   O'Fallon, Judith R ^b   Veeder, Michael H ^b   Miser, Angela W ^b   Mailliard, James A ^b   Michalak, John C ^b   Dose, Ann Marie ^b   Rowland Jr , Ken M ^b   Burnham, Nora L ^b  

^a MAYO CLINIC   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CLONIDINE; TAMOXIFEN;

ADULT; AGED; ARTICLE; BREAST CANCER; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DROWSINESS; ESTROGEN THERAPY; FEMALE; HOT FLUSH; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; TRANSDERMAL DRUG ADMINISTRATION; XEROSTOMIA;

EID: 0028088855     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1994.12.1.155     Document Type: Article

References (11)

1. Casper R, Yen S: Neuroendocrinology of menopausal flushes: An hypothesis of flush mechanism. Clin Endocrinol 22:293-312, 1985
2. Bider D. Masiach S, Serr DM, et al: Endocrinological basis of hot flushes. Obstet Gynecol Surv 44:495-499, 1989
3. Fisher B, Costantino J, Redmond C, et al: A randomized clinical trial evaluating tamoxifen in the treatment of patients with node negative breast cancer who have estrogen-receptor-positive tumors. N Engl J Med 320:479-484, 1989
4. Edington RF, Chagnon JP, Steinberg WM: Clonidine (Dixarit) for menopausal flushing. CMA J 123:23-26, 1980
5. Clayden JR, Bell JW, Pollard P: Menopausal flushing: Double-blind trial of a non-hormonal medication. Br Med J 1:409-412, 1974
6. Nagamani M, Kelver ME, Smith ER: Treatment of menopausal hot flashes with transdermal administration of clonidine. Am J Obstet Gynecol 156:561-565, 1987
7. Laufer LR, Erlik Y, Meldrum DR, et al: Effect of clonidine on hot flashes in postmenopausal women. Obstet Gynecol 60:583-586, 1982
8. Yanes B: Effective treatment for tamoxifen induced hot flashes. Breast Cancer Res Treat 8:89, 1986 (abstr)
9. Erlik Y, Meldrum DR. Lagasse LD, et al: Effect of megestrol acetate on flushing and bone metabolism in post-menopausal women. Maturitas 3:167-172, 1981
10. Bullock JL, Massey FM, Gambrell RD: Use of medroxy-progesterone acetate to prevent menopausal symptoms. Obstet Gynecol 46:165-168, 1975
11. Albrecht BH, Schiff I, Tulchinsky D, et al: Objective evidence that placebo and oral medroxyprogesterone acetate therapy diminish menopausal vasomotor flushes. Am J Obstet Gynecol 139:631-635, 1981