Evaluation of Estrogen Treatment in Female Patients with Dementia of the Alzheimer Type

Endocrine Journal

Volumn 41, Issue 4, 1994, Pages 361-371

  Ohkura, Takeyoshi ^a   Isse, Kunihiro ^b   Akazawa, Kenji ^c   Hamamoto, Makoto ^d   Hagino, Nobuyoshi ^e  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b Departments of Psychiatry ^*  (Japan)

^c Gynecology and Obstetrics   (Japan)

^d Tokyo Metropolitan Tama Geriatric Hospital   (Japan)

^e UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

Author keywords

Cerebral blood flow; Dementia of the Alzheimer type; EEG; Estrogen; Neuropsychological test

Indexed keywords

CONJUGATED ESTROGEN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN BLOOD FLOW; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMENTIA; ELECTROENCEPHALOGRAM; FEMALE; HUMAN; NEUROPSYCHOLOGY; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; AGED; ALZHEIMER DISEASE; ANDROGENS; CEREBROVASCULAR CIRCULATION; ELECTROENCEPHALOGRAPHY; ENDOMETRIUM; ESTROGEN REPLACEMENT THERAPY; ESTROGENS, CONJUGATED (USP); FEMALE; GONADOTROPINS, PITUITARY; HUMANS; NEUROPSYCHOLOGICAL TESTS;

EID: 0028087659     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.41.361     Document Type: Article

References (42)

1. Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, DeLong MR (1982) Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215:1237-1239.
2. Bartus RT, Dean III RL, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217: 408-417.
3. Coyle JT, Price DL, DeLong MR (1983) Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 219:1184-1190.
4. Drachman DA, Leavitt J (1974) Human memory and the cholinergic system. A relationship to aging? Arch Neurol 30:113-121.
5. Perry E (1988) Acetylcholine and Alzheimer's disease. Br J Psychiatry 152: 737-740.
6. Nordberg A, Winblad B (1986) Reduced number of [3H] nicotine and PH] acetylcholine binding sites in the frontal cortex of Alzheimer brains. Neurosci Lett 72: 115-119.
7. Kellar KJ, Whitehouse PJ, Martino-Barrows AM, Marcus K, Price DL (1987) Muscarinic and nicotinic cholinergic binding sites in Alzheimer's disease cerebral cortex. Brain Res 436: 62-68.
8. Whitehouse PJ, Martino AM, Marcus KA, Zweig RM, Singer HS, Price DL, Kellar KJ (1988) Reductions in acetylcholine and nicotine binding in several degenerative diseases. Arch Neurol 45: 722-724.
9. Hagino N, Yamaoka S (1976) A neuro Endocrinol ogical approach to the investigation of septum. In: Defrance J (eds) Septal Nuclei. Prenum Press, New York, 283-334.
10. Luine V, Park D, Joh T, Reis D, McEwen B (1980) Immunochemical demonstration of increased choline acetyltransferase concentration in rat preoptic area after estradiol administration. Brain Res 191: 273-277.
11. Luine VN (1985) Estradiol increases choline acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats. Exp Neurol 89: 484-490.
12. Kaufman H, Vadasz C, Lajtha A (1988) Effects of estradiol and dexamethasone on choline acetyltransferase activity in various rat brain regions. Brain Res 453: 389-392.
13. Morley BJ, Rodriguez-Sierra JF, Clough RW (1983) Increase in hypothalamic nicotinic acetylcholine receptors in prepuberal female rats administered estrogen. Brain Res 278: 262-265.
14. Luine VN, McEwen BS (1983) Sex differences in cholinergic enzymes of diagonal band nuclei in the rat preoptic area. Neuro Endocrinology 36: 475-482.
15. Furuhjelm M, Fedor-Freybergh P (1976) The influence of estrogens on the psyche in climacteric and post-menopausal women. In: Van Keep PA, Greenblatt RB, Albeaux-Fernet MM (eds) Consensus on Menopause Research. Baltimore, University Park Press, 84-93.
16. Hackman BW, Galbraith D (1976) Replacement therapy with piperazine oestrone sulphate ('Harmogen') and its effect on memory. Curr Med Res Opin 4: 303-306.
17. Sherwin BB (1988) Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women. Psychoneuro Endocrinology 13: 345-357.
18. Honjo H, Ogino Y, Naitoh K, Urabe M, Kitawaki J, Yasuda J, Yamamoto T, Ishihara S, Okada H, Yonezawa T, Hayashi K, Nambara T (1989) In vivo effects by estrone sulfate on the central nervous system-senile dementia (Alzheimer's type). J Steroid Biochem 34: 521-525.
19. Hagino N (1981) Aged limbic system. Interactions of estrogen with catecholaminergic and peptidergic synaptic transmissions. Biomed Res 2: 85-108.
20. Fillit H, Weinreb H, Cholst I, Luine V, McEwen B, Amador R, Zabriskie J (1986) Observations in a preliminary open trial of estradiol therapy for senile dementia-Alzheimer's type. Psychoneuro Endocrinology 11: 337-345.
21. Folstein MF, Folstein SE, McHugh PR (1975) MiniMental State. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198.
22. Hasegawa K (1983) The clinical assessment of dementia in the aged: a dementia screening scale for psychogeriatric patients. In: Bergener M (eds) Aging in the Eighties and Beyond: Highlights of the Twelfth International Congress of Gerontology. Springer Publishing, New York, 207-218.
23. American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders, 3rd edn revised. American Psychiatric Association, Washington DC.
24. Hachinski VC, Iliff LD, Zilhka E, DuBoulay GH, McAllister VL, Marshall J, Russell RWR, Simon L (1975) Cerebral blood flow in dementia. Arch Neurol 32: 632-637.
25. Gottfries CG, Brane G, Gullberg B, Steen G (1982) A new rating scale for dementia syndromes. Arch Gerontol Geriatr 1: 311-330.
26. Hamilton M (1976) Development of a rating scale for primary depressive illness. Br J Soc Clin Pyschol 6: 278-296.
27. Johnson KA, Holman BL, Mueller SP, Rosen TJ, English R, Nagel JS, Growdon GH (1988) Single photon emission computed tomography in Alzheimer's disease. Abnormal Iofetamine I 123 uptake reflects dementia severity. Arch Neurol 45: 392-396.
28. Farlow M, Gracon SI, Hershey LA, Lewis KW, Sadowsky CH, Doran-Ureno J (1992) A controlled trial of tacrine in Alzheimer's disease. JAMA 268: 2523-2529.
29. Brown ER, Randt CT, Osborne DP Jr. (1983) Assessment of memory disturbance in aging. In: Agnoli A, Crepaldi G, Spano PF, Trabucci M (eds) Aging: Aging Brain and Ergot Alkaroids. Raven Press, New York, vol 23:131-137.
30. Klaiber EL, Broberman DM, Vogel W, Kobayashi Y (1979) Estrogen therapy for severe persistent depressions in women. Arch Gen Psychiatry 36: 550-554.
31. Gerdes LC, Sonnendecker EWW, Polakow ES (1982) Psychological changes effected by estrogen-progestogen and clonidine treatment in climacteric women. Am J Obstet Gynecol 142: 98-104.
32. Campbell S, Whitehead M (1977) Oestrogen therapy and the menopausal syndrome. Clin Obstet Gynecol 4: 31-47.
33. Ditkoff EC, Crary WG, Cristo M, Lobo RA (1991) Estrogen improves psychological function in asymptomatic postmenopausal women. Obstet Gynecol 78: 991-995.
34. McEwen BS, Biegon A, Fischette CT, Luine VN, Parsons B, Rainbow TC (1984) Toward a neurochemical basis of steroid hormone action. In: Martini L, Ganong WE (eds) Frontiers in Neuro Endocrinology. Raven Press, New York, vol 8:153-176.
35. Toran-Allerand CD (1981) Cellular aspects of sexual differentiation of the brain. In: Jagiello G, Vogel HJ (eds) Bioregulation of Reproduction. Academic Press, New York, 43-57.
36. Jones KJ (1988) Steroid hormones and neurotrophism: relationship to nerve injury. Metab Brain Dis 3:1-18.
37. Arimatsu Y, Hatanaka H (1986) Estrogen treatment enhances survival of cultured amygdala neurons in a defined medium. Dev Brain Res 26:151-159.
38. Goldman H, Skelley EB, Sandman CA, Kastin AJ, Murphy S (1976) Hormones and regional brain blood flow. Pharmacol Biochem Behav 5 (suppl. 1): 165-169.
39. Hamamoto M, Yamazaki M, Igarashi H, Miyazaki T, Isse K, Uchiyama M, Tanaka K, Chiba K, Terashi A (1990) Single photon emission computed tomography in Alzheimer-type dementia. In: Nagatsu T, Fisher A, Yoshida M (eds) Basic, Clinical, and Therapeutic Aspects of Alzheimer's and Parkinson's Diseases. Plenum Press, New York, vol 2: 59-62.
40. Penttila M, Partanen JV, Soininen H, Riekkinen PJ (1985) Quantitative analysis of occipital EEG in different stages of Alzheimer's disease. Electroenceph Clin Neurophysiol 60:1-6.
41. Soininen H, Partanen JV (1988) Quantitative EEG in the diagnosis and follow-up of Alzheimer's disease. In: Giannitrapani D, Murri L (eds) The EEG of Mental Activities. Karger, Basel, 42-49.
42. Uchiyama M, Isse K, Tanaka K, Kuroda A, Komazaki H, Hamamoto M, Igarashi H, Miyazaki T (1990) A clinical EEG study of Alzheimer-type dementia. In: Nagatsu T, Fisher A, Yoshida M (eds) Basic, Clinical, and Therapeutic Aspects of Alzheimer's and Parkinson's Diseases. Plenum Press, New York, vol 2: 159-162.