A comparative study of copper‐67 radiolabeling and kinetic stabilities of antibody‐macrocycle chelate conjugates

Cancer

Volumn 73, Issue 3 S, 1994, Pages 779-786

  Kukis, David L ^a   Diril, Habibe ^a   Greiner, Douglas P ^a   Denardo, Sally J ^a   Denardo, Gerald L ^a   Salako, Qansy A ^a   Meares, Claude F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

antibody; chelates; copper 67; immunoconjugates; radioimmunotherapy

Indexed keywords

ANTIBODY CONJUGATE; CHELATING AGENT; COPPER 67; MACROCYCLIC COMPOUND; MONOCLONAL ANTIBODY;

ANALYTIC METHOD; BLOOD SAMPLING; CONFERENCE PAPER; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; ISOTOPE LABELING; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RADIOIMMUNOTHERAPY; TITRIMETRY;

ANTIBODIES, MONOCLONAL; CHELATING AGENTS; COMPARATIVE STUDY; COPPER RADIOISOTOPES; DRUG STABILITY; HETEROCYCLIC COMPOUNDS; IMMUNOTOXINS; ISOTOPE LABELING; KINETICS; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028085146     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/1097-0142(19940201)73:3+<779::AID-CNCR2820731306>3.0.CO;2-3     Document Type: Article

References (20)

1. Copper‐67‐labeled monoclonal antibody Lym‐1, a potential radiopharmaceutical for cancer therapy: labeling and biodistribution on RAJI tumored mice
2. Copper chelates as probes of biological systems: stable copper complexes with a macrocyclic bifunctional chelating agent
3. Simplified method for conjugating macrocyclic chelating agents to antibodies via 2‐iminothiolane
4. Contamination in trace metal analysis and its control
5. The peptide way to macrocycle bifunctional chelating agents: synthesis of 2‐(p‐nitrobenzyl)‐1,4,7,10‐tetraazacyclododecane‐N,N′,N″,N″‐tetraacetic acid and study of its yttrium (III) complex
6. Synthesis of novel 1,4,7‐triazanonane‐N,N′,N″‐triacetic acid derivatives suitable for protein labeling
7. The practice of peptide synthesis
8. Fluorescamine: a reagent for assay of amino acids, proteins, and primary amino acids in the picomolar range
9. Enzyme alterable alkylating agents VI. Synthesis, chemical properties, toxicities, and clinical trial of haloacetates and haloacetamides containing enzyme susceptible bonds
10. Radioimmunodetection of human B‐cell lymphomas with a radiolabeled tumor‐specific monoclonal antibody (Lym‐1)
11. A centrifuged‐column procedure for the measurement of ligand binding by beef heart F1
12. Conjugation of antibodies with bifunctional chelating agents: isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions
13. Protein techniques
14. Decomposition rates of radiopharmaceutical indium chelates in serum
15. Disc electrophoresis II: method and application to human serum proteins
16. Macrocyclic chelates of radiometals for diagnosis and therapy
17. Pharmacokinetics of copper‐67 conjugated Lym‐1, a potential therapeutic radioimmunoconjugate, in mice and in patients with lymphoma
18. Strategies for enhancement of radioimmunotherapy
19. Stable bifunctional chelates of metals used in radiotherapy