9 Somatostatin: physiology and clinical applications

Bailliere's Clinical Endocrinology and Metabolism

Volumn 8, Issue 1, 1994, Pages 215-236

  Shulkes, Arthur ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

OCTREOTIDE; SOMATOSTATIN; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR;

DIABETES MELLITUS; DIARRHEA; DIGESTIVE SYSTEM FISTULA; ENDOCRINE TUMOR; GALLSTONE FORMATION; GASTROINTESTINAL TRACT; GENE EXPRESSION; MEDIATOR; PANCREAS DISEASE; PEPTIDE SYNTHESIS; PHYSIOLOGY; PROTEIN LOCALIZATION; PROTEIN PROCESSING; REGULATORY MECHANISM; REVIEW; SOMATOSTATIN RELEASE; STEATORRHEA; TUMOR DIAGNOSIS; VARICOSIS;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; GASTROINTESTINAL DISEASES; GASTROINTESTINAL SYSTEM; HUMAN; MOLECULAR SEQUENCE DATA; OCTREOTIDE; RECEPTORS, SOMATOSTATIN; SIGNAL TRANSDUCTION; SOMATOSTATIN; SUPPORT, NON-U.S. GOV'T;

FISTULA;

EID: 0028084775     PISSN: 0950351X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0950-351X(05)80232-0     Document Type: Article

References (107)

1. Somatostatin gene regulation
2. Gastroenteropancreatic endocrine tumors: effect of Sandostatin on tumor growth
3. Distribution and molecular forms of peptides containing somatostatin immunodeterminants in extracts from the entire gastrointestinal tract of man and pig
4. Molecular biology of somatostatin receptors
5. Inhibition of acid formation and stimulation of somatostatin release by cholecystokinin-related peptides in rabbit gastric glands
6. Circulating immunoreactive somatostatin in gastrointestinal diseases
7. Does the somatostatin analogue octreotide protect against ERCP induced pancreatitis?
8. Isolation and characterisation of S. cerevisiae mutants defective in somatostatin expression: cloning and functional role of a yeast gene encoding an aspartyl protease in precursor processing at monobasic cleavage sites
9. Isolation and functional properties of an arginine-selective endoprotease from rat intestinal mucosa
10. Reciprocal regulation of antral gastrin and somatostatin gene expression in omeprazole induced achlorhydria
11. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone
12. Molecular cloning and functional expression of a brain-specific somatostatin receptor
13. Role of octreotide in the prevention of postoperative complications following pancreatic resection
14. Somatostatin and octreotide in gastroenterology
15. Randomized, double-blind, placebo-controlled trial of somatostatin for variceal bleeding
16. Effect of octreotide on refractory AIDS-associated diarrhea. A prospective, multicenter clinical trial
17. Effects of various gastrointestinal peptides on gastric somatostatin release
18. Biosynthetic precursors for somatostatins: gene expression and post-translational processing
19. Role of circulating somatostatin in regulation of gastric acid secretion, gastrin release, and islet cell function. Studies in healthy subjects and duodenal ulcer patients
20. A physiological role for somatostatin-28 as a regulator of insulin secretion
21. The use of somatostatin in the treatment of acute pancreatitis—results of a multicenter trial
22. Gallstones during octreotide therapy
23. Role of cholecystokinin in the control of gastric somatostatin in the rat: in vivo and in vitro studies
24. Circulating prosomatostatin-derived peptides: differential responses to food ingestion
25. Somatostatin and analogues in the treatment of cancer
26. Heterologous processing of prosomatostatin in constitutive and regulated secretory pathways
27. Looking ahead
28. Regulation of the gastrin promoter by epidermal growth factor and neuropeptides
29. Somatostatin gene regulation: an overview
30. Somatostatin and somatostatin analogue (SMS 201-995) in treatment of hormone-secreting tumors of the pituitary and gastrointestinal tract and non-neoplastic diseases of the gut
31. Somatostatin: the early days
32. Circulating somatostatin: physiological regulator of pancreatic function?
33. Differences in the control of somatostatin release from antrum and fundus
34. Vagal control of the release of stomatostatin, vasoactive intestinal polypeptide, gastrin releasing peptide, and HCL from porcine non-antral stomach
35. A randomized controlled trial comparing octreotide and vasopressin in the control of acute esophageal variceal bleeding
36. Effects of a somatostatin analogue SMS 201-995 on hepatic haemodynamics in the pig and on intravariceal pressure in man
37. Helicobacter pylori infection induces a decrease in immunoreactive-somatostatin concentrations of human stomach
38. Inhibition of gastrin gene expression by somatostatin
39. Effect of one year continuous subcutaneous infusion of a somatostatin analogue, octreotide, on early retinopathy, metabolic control and thyroid function in type I (insulin-dependent) diabetes mellitus
40. Treatment of patients with metastatic pancreatic and gastrointestinal tumours with the somatostatin analogue Sandostatin: a phase II study including endocrine effects
41. Somatostatin cells in the rat pyloric antrum, with special reference to the destination of their cytoplasmic processes
42. Treatment of the malignant carcinoid syndrome. Evaulation of a long-acting somatostatin analogue
43. Parallel in vivo and in vitro detection of functional somatostatin receptors in human endocrine pancreatic tumors: consequences with regard to diagnosis, localization, and therapy
44. The role of somatostatin and its analogs in the diagnosis and treatment of tumours
45. Peptide secretory pathways in the GI tract: cytochemical contributions to regulatory physiology of the gut
46. Effect of SMS 201-995 in rapidly progressive diabetic retinopathy
47. The somatostatin receptor in the GI tract
48. Somatostatin analogues inhibit growth of pancreatic cancer by stimulating tyrosine phosphatase
49. Intestinal fat does not inhibit gastric function through a hormonal SOM mechanism in dogs
50. Is somatostatin a humoral regulator of the endocrine pancreas and gastric acid secretion in man?
51. Biochemistry and physiology of gastrointestinal somatostatin
52. Relationship between gastric acid and elevated plasma somatostattinlike immunoreactivity after a mixed meal
53. Identification of a somatostatin-14-generating propeptide converting enzyme as a member of the kex2/furin/PC family
54. The anglerfish somatostatin-28-generating propeptide converting enzyme is an aspartyl protease
55. Influence of endogenous prostaglandins on secretin-mediated inhibition of gastric acid secretion in dogs.
56. Gastric somatostatin: a paracrine regulator of acid secretion
57. From somatostatin to sandostatin: pharmacodynamics and pharmacokinetics
58. Characteristics of the cAMP response unit
59. Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease
60. Polymorphic human somatostatin gene is located on chromosome 3
61. Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28
62. Octreotide and diabetes: theoretical and experimental aspects
63. Somatostatin receptors on canine fundic D-cells: evidence for autocrine regulation of gastric somatostatin.
64. Multiple forms of immunoreactive somatostatin: comparison of distribution in neural and non-neural tissues and portal plasma of the rat
65. Mechanism of action of somatostatin: an overview of receptor function and studies of the molecular characterization and purification of somatostatin receptor proteins
66. Gastrointestinal side-effects of octreotide during long-term treatment with acromegaly
67. Hepatic and renal metabolism of somatostatin-like immunoreactivity
68. The in vivo metabolism of somatostatin 28: possible relationship between diminished metabolism and enhanced biological action
69. Peptides derived by processing of rat prosomatostatin near the amino-terminus: characterization, tissue distribution, and release
70. Prosomatostatin-derived antrin is present in gastric D cells and in portal blood
71. Somatostatin: historical aspects
72. Biochemical and functional properties of somatostatin receptors
73. In vitro detection of somatostatin receptors in human tumors
74. Differential control of somatostatin messenger RNA in rat gastric corpus and antrum
75. Oncological applications of somatostatin analogues
76. The effect of vasoactive intestinal polypeptide on gastric acid secretion is predominantly mediated by somatostatin
77. Physiological and pathophysiological aspects of somatostatin
78. Splanchnic somatostatin: a hormonal regulator of nutrient homeostasis
79. Free somatostatin in the circulation: amounts and molecular sizes of somatostatin-like immunoreactivity in portal, aortic and vena caval plasma of fasting and meal-stimulated dogs
80. Effects of monoclonal antibodies to somatostatin on somatostatin-induced and intestinal fat-induced inhibition of gastric acid secretion in the rat
81. Proprotein and prohormone convertases of the subtilisin family. Recent developments and future perspectives
82. Somatostatin analogue, octreotide, reduces increased glomerular filtration rate and kidney size in insulin-dependent diabetes
83. Human somatostatin I: sequence of the cDNA
84. Circulating forms of somatostatin like immunoreactivity in human plasma
85. Regulation of somatostatin secretion by gastrin and acid dependent mechanisms
86. Somatostatin and its analogues—from basic science to clinical applications
87. STARVATION IN THE RAT: EFFECT ON PEPTIDES OF THE GUT AND BRAIN
88. Somatostatin release induced by gastric-releasing peptide in man. Effect of proximal gastric vagotomy and cholinergic blockade
89. Cholecystokinin potently releases somatostatin from canine fundic mucosal cells in short term culture
90. Evaluation of receptors for somatostatin in various tumors using different analogs
91. Somatostatin—the long lost antral chalone
92. Antral chalone
93. Physiologic scope of the antral inhibitory hormone
94. Somatostatin in the management of gastrointestinal fistulas
95. Somatostatin gene transcription regulated by a bipartite pancreatic islet D-cell specific enhancer coupled synergetically to a cAMP response element
96. Somatostatin gene upstream enhancer element activated by a protein complex consisting of CREB, Isl-1-like, and α-CBF-like transcription factors
97. Long term treatment of 189 acromegalic patients with the somatostatin analog octreotide. Results of the International Multi-Centre Acromegaly Study Group
98. Postprandial exocrine pancreatic function during long-term treatment with the somatostatin analogue SMS 201-995 in acromegalic patients
99. Potential indications for octreotide in endocrinology
100. Proceedings of the discussion ‘Tolerability and safety of sandostatin’
101. The physiology of gastric acid secretion
102. Inhibition of gastrin release by secretin is mediated by somatostatin in cultured rat antral mucosa
103. Regulation of gastric somatostatin gene expression
104. Somatostatin
105. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney
106. Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase
107. Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylyl cyclase