Receptor tyrosine kinases and their targets

Current Opinion in Genetics and Development

Volumn 4, Issue 1, 1994, Pages 5-14

  Kazlauskas, Andrius ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; GROWTH FACTOR; MEMBRANE PROTEIN; PROTEIN TYROSINE KINASE;

AUTOPHOSPHORYLATION; BINDING SITE; CELLULAR DISTRIBUTION; EUKARYOTE; EXTRACELLULAR MATRIX; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMAL; CELL DIFFERENTIATION; CELL DIVISION; DNA-BINDING PROTEINS; HUMAN; OLIGOPEPTIDES; PHOSPHOLIPASE C; PHOSPHOPROTEINS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SUPPORT, U.S. GOV'T, P.H.S.;

EUKARYOTA;

EID: 0028084335     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-437X(94)90085-X     Document Type: Article

References (131)

1. Signalling by Receptor Tyrosine Kinases
2. Oncogenes and Signal Transduction
3. Growth Factor Signaling by Receptor Tyrosine Kinases
4. SH2 and SH3 Domains: Elements That Control Interactions of Cytoplasmic Signaling Proteins
5. The SH2 and SH3 Domains of Mammalian Grb2 Couple the EGF Receptor to the Ras Activator mSos1
6. ras Through the Formation of a Complex of Receptor, Grb2 Adaptor Protein, and Sos Nucleotide Exchange Factor
7. Association of Sos Ras Exchange Protein with Grb2 is Implicated in Tyrosine Kinase Signal Transduction and Transformation
8. The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways
9. Binding of the Ras Activator Son of Sevenless to Insulin Receptor Substrate-1 Signaling Complexes
10. The SH2 and SH3 Domain-Containing Protein GRB2 Links Receptor Tyrosine Kinases to Ras Signaling
11. SH2 Domains Recognize Specific Phosphopeptide Sequences
12. The SH2/SH3 Domain-Containing Prorein GRB2 Interacts with Tyrorosinc-Phosphorylated IRS1 and Shc: Implications for Insulin Control of Ras Signalling
13. Grb2 Mediates the EGF-Dependent Activation of Guanine Nucleotide Exchange on Ras
14. A Novel Transforming Protein (SHC) with an SH2 Domain is Implicated in Mitogenic Signal Transduction
15. Interaction of Shc with the ζ Chain of the T Cell Receptor upon T Cell Activation
16. Regulators and Effectors of ras Proteins
17. Complexes of Ras-GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase
18. Complex Formation Between PAS and RAF and Other Protein Kinases
19. Mammalian Ras Interacts Directly with the Serine/Threonine Kinase Raf
20. ras Proteins Bind to the Amino-Terminal Regulatory Domain of c-Raf-1
21. Direct Interaction of Ras and the Amino-Terminal Region of Raf-1 In Vitro
22. RAF-1 Activates MAP Kinase-Kinase
23. Activation of the MAP Kinase Pathway by the Protein Kinase RAE
24. Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and In Vitro
25. The Mitogen-Activated Protein Kinase Signal Transduction Pathway
26. Differential Regulation of the p72–74 RAF-I Kinase in 3T3 Fibroblasts Expressing ras or src Oncogenes
27. Both p21ras and pp60-src Are Required, but Neither Alone is Sufficient, to Activate the Raf-1 Kinase
28. Activation of c-Raf Protein Kinase by Protein Kinase C Phosphorylation
29. MAP Kinase Regulation: The Oncogene Connection
30. Reconstitution of the Raf-1-MEK-ERK Signal Transduction Pathway in Vitro
31. Phosphatidylinositol 3-Kinase: a Novel Effector
32. Cloning of a Novel, Ubiquitously Expressed Human Phosphaddylinositol 3-Kinase and Identification of its Binding Site on p85
33. Activation of Phosphatidylinositol-3 Kinase by Nerve Growth Factor Involves Indirect Coupling of the trk Proto-Oncogene with Src Homology 2 Domains
34. Phosphatidylinositol 3′-Kinase is Activated by Association with IRS-1 During Insulin Stimulation
35. IRS-1 Activates Phosphatidylinositol 3′-Kinase by Associating with Src Homology 2 Domains of p85
36. Distinct Phosphotyrosines on a Growth Factor Receptor Bind to Specific Molecules that Mediate Different Signalling Pathways
37. GTPase-Activating Protein and Phosphatidylinositol 3-Kinase Bind to Distinct Regions of the Platelet-Derived Growth Factor Receptor β Subunit
38. Phospholipase C-γ 1 and Phosphtidylinositol 3 Kinase are the Downstream Mediators of the PDGF Receptor's Mitogenic Signal
39. Activation of the ζ Isozyme of Protein Kinase C by Phosphatidylinositol 3,4,5-Triphosphate
40. Protein Kinase Cζ Isoform Is Critical for Mitogenic Signal Transduction
41. SH3 Domains Direct Cellular Localization of Signaling Molecules
42. Mutations in Src Homology Regions 2 and 3 of Activated Chicken C-src that Result in Preferential Transformation of Mouse or Chicken Cells
43. v-src and Alter Cellular Morphology
44. c-src Transforming Potential by Mutations Altering the Structure of an Amino Terminal Domain Containing Residues 90–95
45. Deletion of the SH3 Domain of Src Interferes with Regulation by the Phosphorylated Carboxy-Terminal Tyrosine
46. Deletion of an N-Terminal Regulatory Domain of the c-abl Tyrosine Kinase Activates its Oncogenic Potential
47. N-Terminal Mutations Activate the Leukemogenic Potential of the Myristoylated from of c-abl
48. Phosphatidylinositol 3-Kinase: Structure and Expression of the 110 kDa Catalytic Subunit
49. Phosphatidylinositol 3-Kinase Encoded by Yeast VPS34 Gene Essential for Protein Sorting
50. Disruption of PDGF Receptor Internalization by Mutation of the PI3-K Binding Sites
51. 1 Progression
52. Rapamycin-FKBP Specifically Blocks Growth-Dependent Activation of and Signaling by the 70 kDa S6 Protein Kinases
53. s6k Function is Essential for G1 Progression
54. A Tightly Associated Serine/Threonine Protein Kinase Regulates Phosphoinositide 3-Kinase Activity
55. Increase of the Catalytic Activity of Phospholipse C-γ 1 by Tyrosine Phosphorylation
56. Regulation of Phospholipase C-γ 1 by Profilin and Tyrosine Phosphorylation
57. PDGF Stimulation of Inositol Phospholipid Hydrolysis Requires PLC-γ 1 Phosphorylation on Tyrosine Residues 783 and 1254
58. Inositol Trisphosphate and Calcium Signalling
59. Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
60. Altered Growth Regulation and Enhanced Tumorigenicity of NIH 3T3 Fibroblasts Transfected with Protein Kinase C-1 cDNA
61. Overproduction of Protein Kinase C Causes Disordered Growth Control in Rat Fibroblasts
62. PDGF-Induced Activation of Phospholipase C is Not Required for Induction of DNA Synthesis
63. Identification of Two C-Terminal Autophosphorylation Sites in the PDGF β-Receptor Involvement in the Interaction with Phospholipase C-γ
64. Point Mutant in the FGF Receptor Eliminates Phosphatidylinositol Hydrolysis Without Affecting Mitogenesis
65. 2+ Flux but not Mitogenesis
66. c-myc Gene Expression is Stimulated by Agents that Activate Protein Linase C and Does Not Account for the Mitogenic Effect of PDGF
67. Protein Kinase C Mediates Platelet-Derived Growth Factor-Induced Tyrosine Phosphorylation of p42
68. Inhibition of Serum- and Ras-Stimulated DNA Synthesis by Antibodies to Phospholipase C
69. The SIF Binding Element Confers sis/PDGF Inducibility onto the c-fos Promoter
70. Cell-Free Activation of a DNA-Binding Protein by Epidermal Growth Factor
71. A Transcription Factor with SH3 and SH3 Domains is Directly Activated by an Interferon α-Induced Cytoplasmic Protein Tyrosine Kinase(s)
72. Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor
73. A Protein Tyrosine Kinase in the Interferon α/β Signaling Pathway
74. Tyrosine Phosphorylation is Required for Activation of an α-Interferon-Stimulated Transcription Factor
75. In Vitro Activation of Transcription Factor ISGF3 by IFN α Involved a Membrane Associated Tyrosine Phosphatase and Tyrosine Kinase
76. Transcription Factor p91 Interacts with the Epidermal Growth Factor Receptor and Mediates Activation of the c-fos Gene Promoter
77. Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation
78. Induction by EGF and Interferon-γ of Tyrosine Phosphorylated DNA Binding Proteins in Mouse Liver Nuclei
79. A Common Nuclear Signal Transduction Pathway Activated by Growth Factor and Cytokine Receptors
80. A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ
81. Tyrosine Phosphorylation of DNA Binding Proteins by Multiple Cytokines
82. Association of Fyn with the Activated Platelet-Derived Growth Factor Receptor: Requirements for Binding and Phosphorylation
83. Identification of Two Juxtamembrane Autophosphorylation Sites in the PDGF β-Receptor, Involvement in the Interaction with Src Family Tyrosine Kinases
84. Association Between the PDGF Receptor and Members of the Src Family of Tyrosine Kinases
85. PDGF Receptor Sequences Important for Kinases Binding of SRC Family Tyrosine
86. The Src Family Tyrosine Kinases are Required for Platelet-Derived Growth Factor-Mediated Signal Transduction in NIH 3T3 Cells
87. SH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases
88. Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation
89. The 64-kDa Protein that Associates with the Platelet-Derived Growth Factor Receptor β Subunit via Tyr-1009 is the SH2-Containing Phosphotyrosine Phosphatase Syp
90. The Insulin Receptor Substrate 1 Associates with the SH2-Containing Phosphotyrosine Phosphatase SYP
91. Pleiotropic Insulin Signals are Engaged by Multisite Phosphorylation of IRS-1
92. Association of Hematopoietic Cell Phosphatase with c-Kit After Stimulation with c-Kit Ligand
93. Activation of the SH2-Containing Phosphotyrosine Phosphatase SH-PTP2 by its Binding Site, Phosphotyrosine 1009, on the Human Platelet-Derived Growth Factor Receptor β
94. corkscrew Encodes a Putative Protein Tyrosine Phosphatase that Functions to Transduce the Terminal Signal from the Receptor Tyrosine Kinase torso
95. Tyrosines 1021 and 1009 are Phosphorylation Sites in the Carboxy Terminus of the Platelet-Derived Growth Factor Receptor β Subunit and Are Required for Binding of Phospholipase Cγ and a 64-KiloDalton Protein, Respectively
96. Insulin Receptor Substrate-1 (IRS-1) Mediates Insulin and IGF-1 Stimulated Maturation of Xenopus Oocytes
97. IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells
98. Epidermal Growth Factor-Induced Actin Remodeling is Regulated by 5-Lipoxygenase and Cyclooxygenase Products
99. The Small GTP-Binding Protein rho Regulates the Assembly of Focal Adhesions and Actin Stress Fibers in Response to Growth Factors
100. Phospholipase C-β1 is a GTPase-Activating Protein for Gq/22, Its Physiologic Regulator
101. Protein Kinase C Phosphorylation of the EGF Receptor at a Threonine Residue Close to the Cytoplasmic Face of the Plasma Membrane
102. Protein Kinase C Phosphorylation at Thr 654 of the Unoccupied EGF Receptor and EGF Binding Regulate Functional Receptor Loss by Independent Mechanisms
103. Epidermal Growth Factor (EGF) Promotes Phosphorylation at Threonine-654 of the EGF Receptor: Possible Role of Protein Kinase C in Homologous Regulation of the EGF Receptor
104. Autophosphorylation and Protein Kinase C Phosphorylation of the Epidermal Growth Factor Receptor
105. Mechanism of Phosphorylation of the Epidermal Growth Factor Receptor at Threonine 669
106. Isolation and Characterization of Two Growth Factor-Stimulated Protein Kinaes that Phosphorylate the Epidermal Growth Factor Receptor at Threonine 669
107. 671 Phosphorylation Sites Alters Substrate Specificity and Ligand-Induced Internalization of the Epidermal Growth Factor Receptor
108. Increased Kit/SCF Receptor Induced Mitogenicity but Abolished Cell Motility after Inhibition of Protein Kinase C
109. Growth Factor Signaling: Where is the Specificity?
110. SNT, a Differentiation-Specific Target of Neurotrophis Factor-Induced Tyrosine Kinase Activity in Neurons and PC12 Cells
111. mapk (ERK1) by Growth Factors: Correlation Between Late Phase Activation and Mitogenicity
112. mapk Are Required for Fibroblast Proliferation
113. Activated Type I Phosphatidylinositol Kinase is Associated with the Epidermal Growth Factor (EGF) Receptor Following EGF Stimulation
114. Structure of the Insulin Receptor Substrate IRS-1 Defines a Unique Signal Transduction Protein
115. Insulin Stimulation of Phosphatidylinositol 3-Kinase Activity Maps to Insulin Receptor Regions Required for Endogenous Substrate Phosphorylation
116. Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction
117. Autophosphorylation of the PDGF Receptor in the Kinase Insert Region Regulates Interactions with Cell Proteins
118. EGF Induces Tyrosine Phosphorylation of Phospholipase C-II: A Potential Mechanism for EGF Receptor Signaling
119. Tyrosine Kinase Activity is Essential for the Association of Phospholipase C-γ with the Epidermal Growth Factor Receptor
120. Platelet-Derived Growth Factor (PDGF)-Dependent Association of Phospholipase C-γ with the PDGF Receptor Signaling Complex
121. Platelet-Derived Growth Factor (PDGF) Binding Promotes Physical Association of PDGF Receptor with Phospholipase C
122. PDGFβ-Receptor Stimulates Tyrosine Phosphorylation of GAP and Association of GAP with a Signaling Complex
123. Binding of GAP to Activated PDGF Receptors
124. Tyrosine Phosphorylation of ras GTPase-Activating Protein Does Not Require Association with the Epidermal Growth Factor Receptor
125. Phosphorylation of Nck in Response to a Variety of Receptors, Phorbol Myristate Acetate, and Cyclic AMP
126. The SH2 and SH3 Domain-Containing Nck Protein is Oncogenic and a Common Target for Phosphorylation by Different Surface Receptors
127. Nck Associates with the SH2 Domain-Docking protein IRS-1 in Insulin Stimulated Cells
128. Two Signaling Molecules Share a Phosphotyrosine-Containing Binding Site in the Platelet-Derived Growth Factor Receptor