Vascular endothelial growth factor and its receptors

Progress in Growth Factor Research

Volumn 5, Issue 1, 1994, Pages 89-97

  Neufeld, Gera ^a   Tessler, Shoshana ^a   Gitay Goren, Hela ^a   Cohen, Tzafra ^a   Levi, Ben Zion ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Angiogenesis; endothelial cells; flk 1; flt; heparin; hypoxia; KDR; permeabilization; receptors; tumour growth; VEGF

Indexed keywords

ENDOTHELIAL CELL GROWTH FACTOR; GROWTH FACTOR RECEPTOR; HEPARIN; LECTIN RECEPTOR; LYMPHOKINE; PROTEIN TYROSINE KINASE; RECEPTOR PROTEIN TYROSINE KINASES; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANIMAL; DRUG EFFECT; HUMAN; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); REVIEW;

ANIMAL; ENDOTHELIAL GROWTH FACTORS; HEPARIN; HUMAN; LYMPHOKINES; NEOVASCULARIZATION, PATHOLOGIC; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, MITOGEN; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR;

EID: 0028084202     PISSN: 09552235     EISSN: None     Source Type: Journal    
DOI: 10.1016/0955-2235(94)90019-1     Document Type: Article

References (61)

1. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
2. Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells
3. Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells
4. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
5. A highly conserved vascular permeability factor secreted by a human and rodent tumor cell lines
6. Human vascular permeability factor. Isolation from U937 cells
7. Vascular permeability factor, an endothelial cell mitogen related to PDGF
8. Vascular endothelial growth factor is a secreted angiogenic mitogen
9. Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family
10. Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor
11. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
12. The vascular endothelial growth factor family-identification of a fourth molecular species and characterization of alternative splicing of RNA
13. Identification and localization of alternatively spliced mRNAs for vascular endothelial growth factor in human uterus and estrogen regulation in endometrial carcinoma cell lines
14. Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor
15. Glycosylation of vascular endothelial growth factor is not required for its mitogenic activity
16. Dual regulation of vascular endothelial growth bioavailability by genetic and proteolytic mechanisms
17. Characterization of the receptors for vascular endothelial growth factor
18. Glycosylation is essential for efficient secretion but not for permeability-enhancing activity of vascular permeability factor (vascular endothelial growth factor)
19. Regulation of hexose transport in aortic endothelial cells by vascular permeability factor and tumor necrosis factor-alpha, but not by insulin
20. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells
21. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells
22. 2+ and von Willebrand factor release in human endothelial cells
23. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis
24. Characterization of the receptor to vasculotropin on bovine adrenal cortex-derived capillary endothelial cells
25. Specific binding of vascular permeability factor to endothelial cells
26. Interaction of vasculotropin/vascular endothelial cell growth factor with human umbilical vein endothelial cells: Binding, internalization, degradation, and biological effects
27. Vascular endothelial cell growth factor (VEGF) produced by A-431 human epidermoid carcinoma cells and identification of VEGF membrane binding sites
28. The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules
29. Human melanoma cells but not normal melanocytes express vascular endothelial growth factor receptors
30. Molecular and Biological Properties of the Vascular Endothelial Growth Factor Family of Proteins
31. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
32. Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors
33. Signal transduction by receptors with tyrosine kinase activity
34. Nucleotide sequence and expression of a novel human receptor type tyrosine kinase gene (flt) closely related to the fms family
35. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
36. Identification of a new endothelial cell growth factor receptor tyrosine kinase
37. A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit
38. NYK/FLK-1—a putative receptor protein tyrosine kinase isolated from E10 embryonic neuroepithelium is expressed in endothelial cells of the developing embryo
39. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
40. High affinity VEGF binding and developmental expression suggest flk-1 as a major regulator of vasculogenesis and angiogenesis
41. Nature of the interaction of growth factors with suramin
42. Suramin interrupts androgen-inducible autocrine loop involving heparin binding growth factor in mouse mammary cancer (Shionogi Carcinoma-115) cells
43. Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation
44. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
45. Repression of myogenic differentiation by aFGF, bFGF, and K-FGF is dependent on cellular heparin sulfate
46. An essential heparin-binding domain in the fibroblast growth factor receptor kinase
47. Vascular endothelial growth factor (VEGF) binds to alpha-2-macroglobulin and the binding is inhibited by heparin
48. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation
49. Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues
50. Vascular endothelial growth factor in expressed in rat corpus luteum
51. Vascular endothelial growth factor messenger ribonucleic acid expression in primate ovary
52. Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis.
53. Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways
54. What is the evidence that tumors are angiogenesis dependent
55. Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: Concentration in tumor blood vessels
56. Expression of the Vascular Permeability Factor/Vascular Endothelial Growth Factor Gene in Central Nervous System Neoplasms
57. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiongenesis
58. Vascular endothelial growth factor is a potent tumor angiogenesis factor in human gliomas in vivo
59. Inhibition of vascular endothelial growth factor induced angiogenesis suppresses tumor growth in vivo
60. Expression of vascular endothelial growth factor does not promote transformation but confers a growth advatage in vivo to Chinese hamster ovary cells