Fluconazole combined with flucytosine for treatment of cryptococcal meningitis in patients with aids

Clinical Infectious Diseases

Volumn 19, Issue 4, 1994, Pages 741-745

  Larsen, Robert A ^a,b   Bozzette, Samuel A ^a,b   Jones, Brenda E ^a,b   Haghighat, Dennis ^a,b   Leal, Mary Ann ^a,b   Forthal, Donald ^a,b   Bauer, Madeline ^a,b   Tilles, Jeremiah G ^a,b   Mc Cutchan, J Allen ^a,b   Leedom, John M ^a,b,c  

^a LAC USC MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c The California Collaborative Treatment Group ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; FLUCONAZOLE; FLUCYTOSINE;

ABDOMINAL PAIN; ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CEREBROSPINAL FLUID CULTURE; CLINICAL ARTICLE; CLINICAL TRIAL; CRYPTOCOCCUS NEOFORMANS; DIARRHEA; DRUG ERUPTION; EOSINOPHILIA; FEMALE; FUNGAL MENINGITIS; GRANULOCYTOPENIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; NAUSEA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PRURITUS; THROMBOCYTOPENIA; VOMITING;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; CEREBROSPINAL FLUID; CRYPTOCOCCUS NEOFORMANS; DRUG THERAPY, COMBINATION; FEMALE; FLUCONAZOLE; FLUCYTOSINE; HUMAN; MALE; MENINGITIS, CRYPTOCOCCAL; PILOT PROJECTS; PROSPECTIVE STUDIES; SUPPORT, NON-U.S. GOV'T; SURVIVAL ANALYSIS;

EID: 0028083248     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/clinids/19.4.741     Document Type: Article

References (18)

1. Chuck SL, Sande MA. Infections with Crvptoeoccus neoformans in the acquired immunodeficiency syndrome. N Engl J Med 1989; 321:794-9.
2. Larsen RA, Leal MAE, Chan LS. Fluconazole compared with amphotericin B plus flucytosine for cryptococcal meningitis in AIDS: a randomized trial. Ann Intern Med 1990; 113:183-7.
3. Saag MS, Powderly WG, Cloud GA, et al. Comparison of amphotericin B with fluconazole in the treatment of acute AIDS-associated cryptococcal meningitis. N Engl J Med 1992;326:83-9.
4. Kovacs JA, Kovacs AA, Polis M, et al. Cryptococcosis in the acquired immunodeficiency syndrome. Ann Intern Med 1985; 103:533-8.
5. Zuger A, Louie F Holzman RS, Simberkoff MS, Rahal JJ. Cryptococcal disease in patients with the acquired immunodeficiency syndrome: diagnostic features and outcome of treatment. Ann Intern Med 1986;104:234-40.
6. Bennett JE, Dismukes WE, Duma RJ, et al. A comparison of amphotericin B alone and combined with flucytosine in the treatment of cryptococcal meningitis. N Engl J Med 1979;301:126-31.
7. Bryan CS, Mc Farland JA. Cryptococcal meningitis: fatal marrow aplasia from combined therapy. JAMA 1978;239:1068-9.
8. Stamm AM, Diasio RB, Dismukes WE, et al. Toxicity of amphotericin B plus flucytosine in 194 patients with cryptococcal meningitis. Am J Med 1987;83:236-42.
9. Allendoerfer R. Marquis AJ, Rinaldi MG, Graybill JR. Combined therapy with fluconazole and flucytosine in murine cryptococcal meningitis. Antimicrob Agents Chemother 1991;35:726-9.
10. Larsen RA, Bozzette S, Mc Cutchan JA, et al. Persistent Crypiococcus neoformans infection of the prostate after successful treatment of meningitis. Ann Intern Med 1989; 111:125-8.
11. Anthony JC. LeResche L, Niaz U, Von Korff MR, Folstein MF. Limits of the ‘mini-mental state' as a screening test for dementia and delirium among hospital patients. Psychol Med 1982; 12:397-408.
12. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
13. Greenwood M. The natural duration of cancer. In: Reports of public health and medical subjects. Vol 33. London: Her Majesty’s Stationery Office, 1926.
14. Antoniskis D, Larsen RA. Acute, rapidly progressive renal failure with simultaneous use of amphotericin B and pentamidine. Antimicrob Agents Chemother 1990;34:470-2.
15. Fisher MA, Talbot GH, Maislin G, Mc Keon BP, Tynan KP, Strom BL. Risk factors for amphotericin B-associated nephrotoxicity. Am J Med 1989:87:547-52.
16. Maddux MS, Barriere SL. A review of complications of amphotericin B therapy: recommendations for prevention and management. Drug Intell Clin Pharm 1980; 14:177-81.
17. Medoff G, Kobayashi GS. Strategies in the treatment of systemic fungal infections. N Engl J Med 1980;302:145-55.
18. Utz JP, Bennett JE, Brandriss MW, Butler WT, Hill GJ II. Amphotericin B toxicity. Ann Intern Med 1964;61:334-40.