An alternative splicing modifies the C-terminal end of tryptophanyl-tRNA synthetase in murine embryonic stem cells

Journal of Molecular Biology

Volumn 242, Issue 4, 1994, Pages 599-603

  Pajot, Bertrand ^a   Sarger, Claude ^a   Bonnet, Jacques ^b   Garret, Maurice ^a  

^a Institut de Biochimie Cellulaire et Neurochimie du CNRS   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Alternative splicing; Aminoacyl tRNA synthetase; Mammals; Post translational processing; Protein targeting

Indexed keywords

EID: 0028075594     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1994.1608     Document Type: Article

References (23)

1. Buwitt, U., Flohr, T. & Bottger, E. C. (1992). Molecular cloning and characterization of an interferon induced human c DNA with sequence homology to a mammalian peptide chain release factor. EMBO J. 11, 489-496.
2. Chirgwin, J. M., Przybyla, A. E., Mac-Donald, R. J. & Rutter, W J. (1979). Isolation of biologically active ribonucleic acids from sources enriched in ribonucleases. Biochemistry, 18, 5294-5299.
3. Clarke, S. (1992). Protein isoprenylation and méthylation at carboxyl-terminal cysteine residues. Annu. Rev. Biochem. 61, 335-386.
4. Clemens, M. J. (1990). Does protein phosphorylation play a role in translational control by eukaryotic ami noacyl-t RN A synthetases. Trends Biochem. Sci. 15, 172-175.
5. Epely, S., Gros, C., Labouesse, J. & Lemaire, G. (1976). Limited proteolysis of tryptophanyl-t RNA synthetase from beef pancreas. Eur. J. Biochem. 61, 139-146.
6. Eriani, G., Delarue, M., Poch, O., Gangloff, J. & Moras, D. (1990). Partition of t RNA synthetases into two classes based on mutually exclusive sets of sequence motifs. Nature (London) 347, 203-206.
7. Fleckner, J., Rasmussen, H. H. & Justesen, J. (1991). Human interferon y potently induces the synthesis of a 55-k Da protein highly homologous to rabbit peptide chain release factor and bovine tryptophanyl-t RNA synthetase. Proc. Nat. Acad. Sci., U.S.A. 88, 11520-11524.
8. Frolova L. Y., Grigorieva A. Y., Sudomoina M. A., Zinovieva O. L. & Kisselev L. L. (1991). Cloning and nucleotide sequence of the structural gene encoding for human tryptophanyl-t RNA synthetase. Gene, 109, 291-296.
9. Frolova L. Y., Grigorieva A. Y., Sudomoina M. A. & Kisselev L. L. (1993). The human gene encoding tryptophanyl-t RNA synthetase, interferon response elements and intron-exon organisation. Gene, 128, 237-245.
10. Gabius, H. J., Graupner, G. & Cramer, F (1983). Activity patterns of ami noacyl-t RNA synthetases, t RNA methylases, arginyl tranferase and tubulin during aging in Caenorhabditis elegans. Eur. J. Biochem. 131, 213-234.
11. Garret, M., Pajot, B., Trezeguet, V, Labouesse, J., Merle, M., Gandar, J. C., Benedetto, J. P, Sallafranque, M. L., Alterio, J., Gueguen, M., Sarger, C., Labouesse, B. & Bonnet, J. (1991). A mammalian tryptophanyl-t RNA synthetase shows little homology to prokaryotic synthetases but near identity with mammalian peptide chain release factor. Biochemistry, 30, 7811-7817.
12. Green, M. R. (1991). Biochemical mechanisms of constitutive and regulated pre-m RNA splicing. Annu. Rev. Cell Biol. 7, 559-599.
13. Kittle, J. D., Mohr, G., Gianelos, J. A., Wang, H. & Lombowitz A. M. (1991). The Neurospora mitochondrial tyrosyl-t RNA synthetase is sufficient for group O intron splicing in vitro and uses the carboxy terminal t RNA binding domain along with other regions. Gene Develop. 5, 1009-1021.
14. Lee, E C., Bochner, B. R. & Ames, B. N. (1983). Apppp A, heat shock stress and cell oxydation. Proc. Nat. Acad. Sci., U.S.A. 80, 7496-7500.
15. 2-terminal domain. J. Biol. Chem. 268, 5519-5523.
16. Marshal, C. J. (1993). Protein prenylation: a mediator of protein-protein interactions. Science, 259, 1865-1866.
17. McKeown, M. (1992). Alternative RNA splicing. Annu. Rev. Cell. Biol. 8, 133-155.
18. Mirande, M. (1991). Aminoacyl-t RNA synthetase family from prokaryotes and eukaryotes: structural domains and their implication. Prog. Nucl. Acid. Res. 40, 95-124.
19. Rubin, B. Y., Anderson, S. L., Xing, L., Powel, R. J. & Tate, W E (1991). Interferon induces tryptophanyl-t RNA synthetase expression in human fibroblasts. J. Biol. Chem. 266, 24245-24248.
20. Sallafranque, M. L., Garret, M., Benedetto, J. E, Fournier, M., Labouesse, B. & Bonnet, J. (1986). Tryptophanyl-t RNA synthetase is a major soluble protein in bovine pancreas. Biochim. Biophys. Acta, 882, 192-199.
21. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual, 2nd Edit; Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
22. Sanger, F, Miklen, S. & Coulson, A. R. (1977). DNA sequencing with chain-terminating inhibitors. Proc. Nat. Acad. Sci., U.S.A. 74, 5463-5467.
23. Wickens, M. & Takayama, K. (1994) RNA: deviants or emissaries. Nature (London), 367, 17-18.