An assembly domain of the Rous sarcoma virus Gag protein required late in budding

Journal of Virology

Volumn 68, Issue 10, 1994, Pages 6605-6618

  Wills, John W ^a   Cameron, Craig E ^b,c   Wilson, Carol B ^a   Xiang, Yan ^b   Bennett, Robert P ^a   Leis, Jonathan ^b  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; MUTANT PROTEIN; PROLINE; PROTEINASE; RNA DIRECTED DNA POLYMERASE; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; DELETION MUTANT; ENZYME ACTIVITY; GENETIC COMPLEMENTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; ROUS SARCOMA ONCOVIRUS; VIRUS ENVELOPE;

EID: 0028070639     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.68.10.6605-6618.1994     Document Type: Article

References (52)

1. Bennett, R. P., T. D. Nelle, and J. W. Wills. 1993. Functional chimeras of the Rous sarcoma virus and human immunodeficiency virus Gag proteins. J. Virol. 67:6487-6498.
2. Bennett, R. P., S. Rhee, R. C. Craven, E. Hunter, and J. W. Wills. 1991. Amino acids encoded downstream of gag are not required by Rous sarcoma virus protease during Gag-mediated assembly. J. Virol. 65:272-280.
3. Bennett, R. P., and J. W. Wills. Molecular interactions between the Gag proteins of Rous sarcoma virus and murine leukemia virus. Submitted for publication.
4. Bizub, D., I. T. Weber, C. E. Cameron, J. P. Leis, and A. M. Skalka. 1991. A range of catalytic efficiencies with avian retroviral protease subunits genetically linked to form single polypeptide chains. J. Biol. Chem. 266:4951-4958.
5. Bowerman, B., P. O. Brown, J. M. Bishop, and H. E. Varmus. 1989. A nucleoprotein complex mediates the integration of retroviral DNA. Genes Dev. 3:469-478.
6. Bryant, M., and L. Ratner. 1990. Myristoylation-dependent replication and assembly of human immunodeficiency virus 1. Proc. Natl. Acad. Sci. USA 87:523-527.
7. Bukrinsky, M. I., S. Haggerty, M. P. Dempsey, N. Sharova, A. Adzhubel, L. Spitz, P. Lewis, D. Goldfarb, M. Emerman, and M. Stevenson. 1993. A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. Nature (London) 365:666-669.
8. Burstein, H., D. Bizub, M. Kotler, G. Schatz, V. M. Vogt, and A. M. Skalka. 1992. Processing of avian retroviral gag polyprotein precursors is blocked by a mutation at the NC-PR cleavage site. J. Virol. 66:1781-1785.
9. Burstein, H., D. Bizub, and A. M. Skalka. 1991. Assembly and processing of avian retroviral gag polyproteins containing linked protease dimers. J. Virol. 65:6165-6172.
10. Cameron, C. E., B. Grinde, P. Jacques, J. Jentoft, J. Leis, A. Wlodawer, and I. T. Weber. 1993. Comparison of the substrate-binding pockets of the Rous sarcoma virus and human immunodeficiency virus type 1 proteases. J. Biol. Chem. 268:11711-11720.
11. Cameron, C. E., B. Grinde, J. Jentoft, J. Leis, I. T. Weber, T. D. Copeland, and A. Wlodawer. 1992. Mechanism of inhibition of the retroviral protease by a Rous sarcoma virus peptide substrate representing the cleavage site between the gag p2 and p10 proteins. J. Biol. Chem. 267:23735-23741.
12. Cheung, O.-S., R. E. Smith, M. P. Stone, and W. K. Joklik. 1972. Comparison of immature (rapid harvest) and mature Rous sarcoma virus particles. Virology 50:851-864.
13. Craven, R. C., R. P. Bennett, and J. W. Wills. 1991. Role of the avian retroviral protease in the activation of reverse transcriptase during virion assembly. J. Virol. 65:6205-6217.
14. Craven, R. C., A. E. Leure-duPree, C. R. Erdie, C. B. Wilson, and J. W. Wills. 1993. Necessity of the spacer peptide between CA and NC in the Rous sarcoma virus Gag protein. J. Virol. 67:6246-6252.
15. a to stimulate ATP hydrolysis. Cell 62:875-887.
16. Dickson, C., and M. Atterwill. 1978. Polyproteins related to the major core protein of mouse mammary tumor virus. J. Virol. 26:660-672.
17. Dupraz, P., and P.-F. Spahr. 1993. Analysis of deletions and thermosensitive mutations in Rous sarcoma virus gag protein p10. J. Virol. 67:3826-3834.
18. Gelderblom, H. 1990. Morphogenesis, maturation, and fine structure of lentiviruses, p. 159-180. In L. H. Pearl (ed.), Retroviral proteases: control of maturation and morphogenesis. Stockton Press, New York.
19. Goff, S. P., and L. I. Lobel. 1987. Mutants of murine leukemia viruses and retroviral replication. Biochim. Biophys. Acta 907:93-123.
20. Gonterak, R. R., M. T. McNally, and K. Beemon. 1993. Mutation of an RSV intronic element abolishes both U11/U12 snRNP binding and negative regulation of splicing. Genes Dev. 7:1926-1936.
21. Gorelick, R. J., L. E. Henderson, J. P. Hanser, and A. Rein. 1988. Point mutants of Moloney murine leukemia virus that fail to package viral RNA: evidence for specific RNA recognition by a "zinc finger-like" protein sequence. Proc. Natl. Acad. Sci. USA 85:8420-8424.
22. Gottlinger, H. G., J. G. Sodroski, and W. A. Haseltine. 1989. Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 86:5781-5785.
23. Kaplan, A. H., and R. Swanstrom. 1991. Human immunodeficiency virus type 1 Gag proteins are processed in two cellular compartments. Proc. Natl. Acad. Sci. USA 88-4528-4532.
24. Karacostas, V., E. J. Wolffe, K. Nagashima, M. A. Gonda, and B. Moss. 1993. Overexpression of the HIV-1 gag-pol polyprotein results in intracellular activation of HIV-1 protease and inhibition of assembly and budding of virus-like particles. Virology 193:661-671.
25. Krausslich, H. G. 1991. Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity. Proc. Natl. Acad. Sci. USA 88:3213-3217.
26. Krausslich, H. G. 1992. Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation. J. Virol. 66:567-572.
27. Kunkel, T. A., K. Bebenek, and J. McClary. 1991. Efficient site-directed mutagenesis using uracil-containing DNA. Methods Enzymol. 204:125-139.
28. Leis, J., D. Baltimore, J. M. Bishop, J. Coffin, E. Feissner, S. P. Goff, S. Oroszlan, H. Robinson, A. M. Skalka, H. M. Temin, and V. Vogt. 1988. Standardized and simplified nomenclature for proteins common to all retroviruses. J. Virol. 62:1808-1809.
29. Luftig, R. B., and Y. Yoshinaka. 1978. Rauscher leukemia virus populations enriched for "immature" virions contain increased amounts of P70, the gag gene product. J. Virol. 25:416-421.
30. Mergener, K., M. Facke, R. Welker, V. Brinkmann, H. R. Gelderblom, and H. G. Krausslich. 1992. Analysis of HIV particle formation using transient expression of subviral constructs in mammalian cells. Virology 186:25-39.
31. Nelle, T. D., and J. W. Wills. 1994. Unpublished data.
32. Pal, R., M. S. Reitz, Jr., E. Tschachler, R. C. Gallo, M. G. Sarngadharan, and F. D. Veronese. 1990. Myristoylation of gag proteins of HIV-1 plays an important role in virus assembly. AIDS Res. Hum. Retroviruses 6:721-730.
33. src can direct myristylation and plasma membrane localization when fused to heterologous proteins. Nature (London) 346:84-86.
34. Peng, C., N. T. Chang, and T. W. Chang. 1991. Identification and characterization of human immunodeficiency virus type 1 gag-pol fusion protein in transfected mammalian cells. J. Virol. 65:2751-2756.
35. Pepinsky, R. B., R. J. Mattaliano, and V. M. Vogt. 1986. Structure and processing of the p2 region of avian sarcoma and leukemia virus gag precursor polyprotein. J. Virol. 58:50-58.
36. gag is essential for virus particle formation by Moloney murine leukemia virus. Proc. Natl. Acad. Sci. USA 83:7246-7250.
37. Royer, H., S. S. Hong, B. Gay, M. Cerutti, and P. Boulanger. 1992. Expression and extracellular release of human immunodeficiency virus type 1 Gag precursors by recombinant baculovirus-infected cells. J. Virol. 66:3230-3235.
38. Sakalian, M., J. W. Wills, and V. M. Vogt. 1994. Efficiency and selectivity of RNA packaging by Rous sarcoma virus Gag deletion mutants J. Virol. 68:5969-5981.
39. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
40. gag is excluded from virus assembly and maturation events. J. Virol. 63:2370-2373.
41. Schwartz, D. E., R. Tizard, and W. Gilbert. 1983. Nucleotide sequence of Rous sarcoma virus. Cell 32:853-869.
42. Skalka, A. M. 1989. Retroviral proteases: first glimpse at the anatomy of a processing machine. Cell 56:911-913.
43. Stewart, L., G. Schatz, and V. M. Vogt. 1990. Properties of avian retrovirus particles defective in viral protease. J. Virol. 64:5076-5092.
44. Stoltzfus, C. M., and P. N. Snyder. 1975. Structure of B77 sarcoma virus RNA: stabilization of RNA after packaging. J. Virol. 16: 1161-1170.
45. Teich, N. 1984. Taxonomy of retroviruses, p. 25-207. In R. Weiss, N. Teich, H. Varmus, and J. Coffin (ed.), RNA tumor viruses, vol. 1. Cold Spring Harbor Laboratory, Cold Spring Harbor N.Y.
46. van Beveren, C., J. Coffin, and S. Hughes. 1985. Appendix B, p. 567-1148. In R. Weiss, N. Teich, H. Varmus, and J. Coffin (ed.), RNA tumor viruses, vol. 2. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
47. Weldon, R. A., Jr., C. R. Erdie, M. G. Oliver, and J. W. Wills. 1990. Incorporation of chimeric Gag protein into retroviral particles. J. Virol. 64:4169-4179.
48. Weldon, R. A., Jr., and J. W. Wills. 1993. Characterization of a small (25-kilodalton) derivative of the Rous sarcoma virus Gag protein competent for particle release. J. Virol. 67:5550-5561.
49. Wills, J. W., and R. C. Craven. 1991. Form, function and use of retroviral Gag proteins. AIDS 5:639-654. (Editorial.)
50. Wills, J. W., R. C. Craven, and J. A. Achacoso. 1989. Creation and expression of myristylated forms of Rous sarcoma virus Gag protein in mammalian cells. J. Virol. 63:4331-4343.
51. src. J. Virol. 65:3804-3812.
52. Zhou, W., L. J. Parent, J. W. Wills and M. D. Resh. 1994. Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids. J. Virol. 68: 2556-2569.