Chelation therapy for intermittent claudication: A double-blind, randomized, controlled trial

Circulation

Volumn 90, Issue 3, 1994, Pages 1194-1199

  Van Rij, Andre M ^a   Solomon, Clive ^a   Packer, Stephen G K ^a   Hopkins, William G ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

atherosclerosis; lifestyle; peripheral vascular disease

Indexed keywords

EDETIC ACID;

ADULT; AGED; ARTICLE; CHELATION THERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERMITTENT CLAUDICATION; LIFESTYLE; MALE; NEW ZEALAND; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; PULSE PRESSURE; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; WALKING SPEED;

EID: 0028070636     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.90.3.1194     Document Type: Article

References (32)

1. Blumer W, Cranton EM. Ninety percent reduction in cancer mortality after chelation therapy with EDTA. J Adv Med. 1989;2: 183-187.
2. Olszewer E, Carter JC. EDTA chelation therapy in chronic degenerative disease. Med Hypotheses. 1988;27:41-49.
3. Olszewer E, Carter JP. EDTA chelation therapy: a retrospective study of 2,870 patients. J Adv Med. 1989;2:197-211.
4. Godfrey ME. EDTA chelation as a treatment of arteriosclerosis. N Z Med J. 1990;103:162-163.
5. Casdorph RH, Farr CH. EDTA chelation therapy III: treatment of peripheral arterial occlusion, an alternative to amputation. J Hol Med. 1983;5:3-15.
6. Diagnostic and therapeutic technology assessment: chelation therapy. JAMA. 1983;250:672.
7. Scott PJ. Chelation therapy: evolution or devolution of a nostrum? N Z Med J. 1988;101:109-110.
8. Scott PJ. Chelation therapy for degenerative vascular disease. N Z Med J. 1982;95:538-539.
9. Robinson D. Chelation therapy. N Z Med J. 1982;95:750. Letter.
10. Soffer A. Chelation clinics: an abuse of the physician's freedom of choice. Arch Intern Med. 1984;144:1741-1742.
11. Lyons RD. Chelation: miracle cure or false hope? Med J Aust. 1985;142:519-520.
12. Thompson LJ. Chelation therapy. N Z Med J. 1990;103:326-327.
13. Patterson R. Chelation therapy and Uncle John. CMAJ. 1989;140: 829-831.
14. Clark NE, Clark CN, Mosher RF. The "in vivo" dissolution of metastatic calcium: an approach to atherosclerosis. Am J Med Sci. 1955;229:142-149.
15. Cranton EM, Frackelton JP. Free radical pathology in ageassociated diseases: treatment with EDTA Chelation, nutrition, and antioxidants. J Hol Med. 1984;6:6-37.
16. Casdorph RH. EDTA Chelation therapy: efficacy in arteriosclerotic heart disease. J Hol Med. 1981;3:53-59.
17. Olszewer E, Sabbag FC, Carter JA. A pilot double-blind study of sodium-magnesium EDTA in peripheral vascular disease. J Natl Med Assoc. 1990;82:173-177.
18. Guldager B, Jelnes R, Jørgensen SJ, Nielsen JS, Klærke A, Mogensen K, Larsen KE, Reimer E, Holm J, Ottesen S. EDTA treatment of intermittent claudication: a double-blind, placebo-controlled study. J Intern Med. 1992;231:261-267.
19. Sloth-Nielsen J, Guldager B, Mouitzen C, Lund EB, Egeblad M, Nørregaard O, Jørgenson SL, Jelnes R. Arteriographic findings in EDTA chelation therapy on peripheral arteriosclerosis. Am J Surg. 1991;162:122-125.
20. Cranton EM, Frackelton JP. Negative Danish study of EDTA chelation biased. Townsend Letter for Doctors. 1992;July:604-605. Letter.
21. Chelation Therapy Clinic. Chelation Therapy - The Treatment of Choice for Relief from, and Prevention of, Cardiovascular and AgeRelated Diseases. Auckland, New Zealand: The Chelation Therapy Clinic; 1987.
22. Johnston KW, Taraschuk IC. Validation of the role of pulsatility index in quantification of the severity of peripheral occlusive disease. Am J Surg, 1976;131:295-297.
23. 2 in health and peripheral arterial occlusive disease. Surgery. 1982;91:156-163.
24. Powers EW, Frayer WW. Laser Doppler measurements of blood flow in the microcirculation. Plast Reconstr Surg. 1978;61:250-255.
25. Bruce RA. Exercise testing of patients with coronary disease: principles and normal standards for evaluation. Ann Clin Res. 1971;3:323-332.
26. Wade CR, Jackson PG, van Rij AM. Quantitation of malondialdehyde (MDA) in plasma, by ion-pairing reverse phase high performance liquid chromatography. Biochem Med. 1985;33:291-296.
27. Russell DG, Wilson NC. Life in New Zealand Commission Report, I: Executive Overview. Dunedin, New Zealand: University of Otago; 1991.
28. Goldberg D. The Detection of Psychiatric Illness by Questionnaire. London, England: Oxford University Press, Inc; 1972.
29. McNair D, Lorr M, Droppleman LF. Manual for the Profile of Mood States. San Diego, Calif: Educational and Industrial Testing Service; 1971.
30. Cranton EM. Protocol of the American College of Advancement in Medicine for the Safe and Effective Administration of EDTA Chelation Therapy. Laguna Hills, Calif; American College of Advancement in Medicine; 1989.
31. Meltzer LE, Kitchell JR, Palmon FJ. The long term use, side effects, and toxicity of disodium ethyldiamine tetraacetic acid (EDTA). Am J Med Sci. 1961;242:51-57.
32. Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. New York, NY: Academic Press Inc; 1977.