Alveolar type II epithelial cells produce interleukin-6 in vitro and in vivo: Regulation by alveolar macrophage secretory products

Journal of Clinical Investigation

Volumn 94, Issue 2, 1994, Pages 731-740

  Crestani, Bruno ^a   Cornillet, Pascale ^c   Dehoux, Monique ^a,b   Rolland, Corinne ^a   Guenounou, Moncef ^b   Aubier, Michel ^a,d  

^a INSERM   (France)

^b Faculté Xavier Bichat   (France)

^c SERVICE DE DERMATOLOGIE   (France)

^d BICHAT HOSPITAL   (France)

Author keywords

alveolar macrophages; cytokines; human lung; lipopolysaccharide; pulmonary fibrosis

Indexed keywords

ANTISERUM; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 6; MESSENGER RNA; RECOMBINANT GAMMA INTERFERON; RECOMBINANT INTERLEUKIN 1BETA; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; LUNG ALVEOLUS CELL TYPE 2; LUNG FIBROSIS; MACROPHAGE FUNCTION; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT;

EID: 0028068072     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI117392     Document Type: Article

References (50)

1. Mason, J., and M. C. Williams. 1977. Type II alveolar cell. Defender of the alveolus. Am. Rev. Respir. Dis. 116:81-91.
2. Standiford, T. J., S. L. Kunkel, M. A. Basha, S. W. Chensue, J. P. I. Lynch, G. B. Toews, J. Westwick, and R. J. Strieter. 1990. Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung. J. Clin. Invest. 86:1945-1953.
3. Hahon, N., and V. Castranova. 1989. Interferon production in rat type II pneumocytes and alveolar macrophages. Exp. Lung Res. 15:429-445.
4. Standiford, T. J., S. L. Kunkel, S. H. Phan, B. J. Rollins, and R. M. Strieter. 1991. Alveolar macrophage-derived cytokines induce monocyte chemoattractant protein-1 expression from human pulmonary type II-like epithelial cells. J. Biol. Chem. 266:9912-9918.
5. Khalil, N., R. N. O'Connor, H. W. Unruh, P. W. Warren, K. C. Flanders, A. Kemp, O. H. Bereznay, and A. H. Greenberg. 1991. Increased production and immunohistochemical localization of transforming growth factor beta in idiopathic pulmonary fibrosis. Am. J. Respir. Cell. Mol. Biol. 5:155-162.
6. Antoniades, H. N., M. A. Bravo, R. E. Avila, T. Galanopoulos, and J. Neville-Golden. 1990. Platelet-derived growth factor in idiopathic pulmonary fibrosis. J. Clin. Invest. 86:1055-1064.
7. Vignaud, J. M., M. Allam, N. Martinet, M. Pech, F. Plenat, and Y. Martinet. 1991. Presence of platelet-derived growth factor in normal and fibrotic lung is specifically associated with interstitial macrophages, while both interstitial macrophages and alveolar epithelial cells express the C-sis proto-oncogene. Am. J. Respir. Cell. Mol. Biol. 5:531-538.
8. Tazi, A., F. Bouchonnet, M. Grandsaigne, L. Boumsell, A. J. Hance, and P. Soler. 1993. Evidence that granulocyte-macrophage colony stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers. J. Clin. Invest. 91:566-576.
9. Krueger, J., A. Ray, I. Tamm, and P. B. Sehgal. 1991. Expression and function of interleukin-6 in epithelial cells. J. Cell. Biochem. 45:327-334.
10. Akira, S., T. Hirano, T. Taga, and T. Kishimoto. 1990. Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB (Fed. Am. Soc. Exp. Biol.) J. 4:2860-2867.
11. Elias, J. A., and V. Lentz. 1990. IL-1 and tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA. J. Immunol. 145:161-166.
12. May, L. T., G. Torcia, F. Cozzolino, A. Ray, S. B. Tatter, U. Santhanam, P. B. Seghal, and D. Stern. 1989. Interleukin-6 gene expression in human endothelial cells, RNA start sites, multiple IL-6 proteins and inhibition of proliferation. Biochem. Biophys. Res. Commun. 159:991-998.
13. Zhou, D., A. Munster, and R. A. Winchurch. 1991. Pathologic concentrations of interleukin 6 inhibit T cell responses via induction of activation of TGF-β. FASEB (Fed. Am. Soc. Exp. Biol.) J. 5:2582-2585.
14. Ulich, T. R., S. Yin, K. Guo, E. S. Yi, D. Remick, and J. Del Castillo. 1991. Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation. Am. J. Pathol. 138:1097-1101.
15. Jones, K. P., S. P. Reynolds, S. J. Capper, S. Kalinka, J. H. Edwards, and B. H. Davies. 1991. Measurement of interleukin-6 in bronchoalveolar lavage fluid by radioimmunoassay: differences between patients with interstitial lung disease and control subjects. Clin. Exp. Immunol. 83:30-34.
16. Grigg, J. M., and A. Barber. 1992. Increased levels of bronchoalveolar lavage fluid interleukin-6 in preterm ventilated infants after prolonged rupture of membranes. Am. Rev. Respir. Dis. 145:782-786.
17. Soliman, D. M., and H. I. I. Twigg. 1992. Cigarette smoking decreases bioactive interleukin-6 secretion by alveolar macrophages. Am. J. Physiol. (Lung Cell Mol Physiol 7). 236:L471-L478.
18. Crestani, B., C. Rolland, A. Petiet, N. Colas-Linhart, and M. Aubier. 1993. Cell surface carbohydrates modulate neutrophil adherence to alveolar type II cells in vitro. Am. J. Physiol. (Lung Cell Mol Physiol 8). 264:L391-L400.
19. Dobbs, L. G. 1990. Isolation and culture of alveolar type II cells. Am. J. Physiol. (Lung Cell Mol Physiol 2). 258:L134-L147.
20. Rothman, B. L., M. Merrow, A. Despins, T. Kennedy, and D. L. Kreutzer. 1989. Effect of lipopolysaccharide on C3 and C5 production by human lung cells. J. Immunol. 143:196-202.
21. Paine, R., A. Chavis, D. Gaposchkin, P. Christensen, C. H. Mody, L. A. Turka, and G. B. Toews. 1992. A factor secreted by a human pulmonary alveolar epithelial-like cell line blocks T-cell proliferation between G1 and S phase. Am. J. Respir. Cell. Mol. Biol. 6:658-666.
22. Boutten, A., M. Dehoux, M. Deschenes, J. D. Rouzeau, P. N. Bories, and G. Durand. 1992. Alpha 1-acid glycoprotein potentiates lipopolysaccharide-induced secretion of interleukin-6 and tumor necrosis factor-alpha by human monocytes and alveolar and peritoneal macrophages. Eur. J. Immunol. 22:2687-2695.
23. Aarden, L. A., E. R. De Groot, D. L. Schaap, and P. J. Landsorp. 1987. Production of hybridoma growth factor by human monocytes. Eur. J. Immunol. 17:1411-1416.
24. Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:55-63.
25. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
26. Hirano, T., K. Yasukawa, H. Harada, T. Taga, Y. Watanabe, T. Matsuda, S. Kashiwamura, K. Nakajima, K. Koyama, K. Iwamatsu, S. Tsunasawa, F. Sakiyama, H. Matsui, Y. Takahara, T. Taniguchi, and T. Kishimoto. 1986. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature (Lond.) 324:73-76.
27. Chin, Y., J. Cai, and K. Johnson. 1990. Lymphocyte adhesion to cultured Peyer's patch high endothelial venule cells is mediated by organ-specific homing receptors and can be regulated by cytokines. J. Immunol. 145:3669-3677.
28. Edelson, J. D., J. M. Shannon, and R. J. Mason. 1988. Alkaline phosphatase: a marker of type II cell differentiation. Am. Rev. Respir. Dis. 138:1268-1275.
29. Hirano, T., S. Akira, T. Taga, and T. Kishimoto. 1990. Biological and clinical aspects of interleukin 6. Immunol. Today. 11:443-449.
30. Ostinelli, J., M. Dehoux, M. Dechenes, N. Seta, J. L. Trouillet, C. Muller, and M. Aubier. 1991. Local production of cytokines in unilateral community acquired pneumonia. Am. Rev. Respir. Dis. 143:A392.
31. Hack, C. E., E. R. De Groot, R. J. F. Felt-Bersma, J. H. Nuijens, R. J. M. Strack Van Schijndel, A. J. M. Eerenberg-Belmer, L. G. Thijs, and L. A. Aarden. 1989. Increased plasma levels of interleukin-6 in sepsis. Blood. 74:1704-1710.
32. Kotloff, R. M., J. Little, and J. A. Elias. 1990. Human alveolar macrophage and blood monocyte interleukin-6 production. Am. J. Respir. Cell. Mol. Biol. 3:497-505.
33. Cromwell, O., Q. Hamid, C. J. Corrigan, J. Barkans, Q. Meng, and P. D. Collins. 1992. Expression and generation of interleukin-8, IL-6 and granulocyte-macrophage colony-stimulating factor by bronchial epithelial cells and enhancement by IL-1β and tumor necrosis factor α. Immunology. 77:330-337.
34. Humbert, M., O. Devergne, J. Cerrina, B. Rain, G. Simonneau, P. Dartevelle, P. Duroux, P. Galanaud, and D. Emilie. 1992. Activation of macrophages and cytotoxic cells during cytomegalovirus pneumonia complicating lung transplantations. Am. Rev. Respir. Dis. 145:1178-1184.
35. Sanceau, J., F. Beranger, C. Gaudelet, and J. Wietzerbin. 1990. Interferon-gamma is an essential cosignal for triggering IFN-β2/BSF-2/IL-6 gene expression in human monocytic cell lines. Ann NY Acad. Sci. 557:130-139.
36. Sanceau, J., J. Wijdenes, M. Revel, and J. Wietzerbin. 1991. IL-6 and IL-6 receptor modulation by IFN-gamma and tumor necrosis factor alpha in human monocytic cell line (THP-1). J. Immunol. 147:2630-2637.
37. Crouch, E. 1990. Pathobiology of pulmonary fibrosis. Am. J. Physiol. (Lung Cell Mol. Physiol. 3). 259:L159-L184.
38. Ayars, G. H., L. C. Altman, H. Rosen, and T. Doyle. 1984. The injurious effect of neutrophils on pneumocytes in vitro. Am. Rev. Respir. Dis. 130:964-973.
39. Simon, R. H., P. D. Dehart, and R. F. Todd III. 1986. Neutrophil-induced injury of rat alveolar epithelial cells. J. Clin. Invest. 78:1375-1386.
40. Strunk, R. C., D. M. Eldlen, and R. J. Mason. 1988. Pulmonary alveolar type II epithelial cells synthesize and secrete proteins of the classical and alternative complement pathways. J. Clin. Invest. 81:1419-1426.
41. Cott, G. R., J. Y. Westcott, and N. F. Voelkel. 1990. Prostaglandin and leukotriene production by alveolar type II cells in vitro. Am. J. Physiol. (Lung Cell. Mol. Physiol. 2). 258:L179-L187.
42. Paine, R. I., C. H. Mody, A. Chavis, M. A. Spahr, L. A. Turka, and G. B. Toews. 1991. Alveolar epithelial cells block lymphocyte proliferation in vitro without inhibiting activation. Am. J. Respir. Cell. Mol. Biol. 5:221-229.
43. Crapo, J. D., B. E. Barry, P. Gehr, M. Bachofen, and E. R. Weibel. 1982. Cell number and cell characteristics of the normal human lung. Am. Rev. Respir. Dis. 125:332-337.
44. Crapo, J. D., B. E. Barry, H. A. Foscue, and J. S. Shelburne. 1980. Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen. Am. Rev. Respir. Dis. 122:123-145.
45. Haies, D. M., J. Gil, and E. R. Weibel. 1981. Morphometric study of rat lung cells. Am. Rev. Respir. Dis. 123:533-541.
46. Kawanami, O., V. J. Ferrans, and R. G. Crystal. 1982. Structure of alveolar epithelial cells in patients with fibrotic lung disorders. Lab. Invest. 46:39-53.
47. Parra, S. C., R. Burnette, H. P. Price, and T. Takaro. 1986. Zonal distribution of alveolar macrophages, type II pneumocytes, and alveolar septal connective tissue gaps in adult human lungs. Am. Rev. Respir. Dis. 133:908-912.
48. Schindler, R., J. Mancilla, S. Endres, R. Ghorbani, S. C. Clark, and C. A. Dinarello. 1990. Correlations and interactions in the production of interleukin 6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood. 75:40-47.
49. Perlmutter, D. H., L. T. May, and P. B. Sehgal. 1989. Interferon β2/ interleukin 6 modulates synthesis of α1-antitrypsin in human mononuclear phagocytes and in human hepatoma cells. J. Clin. Invest. 84:138-144.
50. Tanner, J., and G. Tosato. 1991. Impairment of natural killer functions by interleukin 6 increases lymphoblastoid cell tumorigenicity in athymic mice. J. Clin. Invest. 88:239-247.