Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia

Journal of Clinical Investigation

Volumn 94, Issue 5, 1994, Pages 1996-2001

  Synold, Timothy W ^b   Relling, Mary V ^b   Boyett, James M ^b   Rivera, Gaston K ^b   Sandlund, John T ^b   Mahmoud, Hazem ^b   Crist, William M ^b   Pui, Ching Hon ^b   Evans, William E ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b NONE

Author keywords

folylpolyglutamate synthetase; hyperdiploidy; T lineage leukemia

Indexed keywords

ASPARAGINASE; CYTARABINE; DAUNORUBICIN; ETOPOSIDE; FOLINIC ACID; FOLYLPOLYGLUTAMATE SYNTHASE; METHOTREXATE; METHOTREXATE POLYGLUTAMATE; PREDNISONE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; BLAST CELL; CELL CYCLE S PHASE; CELL LINEAGE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACCUMULATION; FEMALE; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; INFANT; INTRAVENOUS DRUG ADMINISTRATION; LEUKEMIA REMISSION; LYMPHOBLAST; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PLOIDY; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL;

EID: 0028063423     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI117552     Document Type: Article

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