Molecular effects of 2′,2′-difluorodeoxycytidine (gemcitabine) on DNA replication in intact HL-60 cells

Biochemical Pharmacology

Volumn 48, Issue 8, 1994, Pages 1619-1630

  Ross, Douglas D ^a,b,c   Cuddy, Dennis P ^a  

^a UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTER   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c BALTIMORE VA MEDICAL CENTER   (United States)

Author keywords

antimetabolite; ara C; DNA synthesis; drug mechanism of action; Gemcitabine

Indexed keywords

2,2' DIFLUORODEOXYURIDINE; CYTARABINE; DEOXYCYTIDINE TRIPHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; DNA; DNA FRAGMENT; GEMCITABINE; HYDROXYUREA; RADIOISOTOPE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA REPLICATION; DNA SYNTHESIS; DRUG MECHANISM; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; CELL DEATH; COMPARATIVE STUDY; CYTARABINE; DEOXYCYTIDINE; DEOXYCYTOSINE NUCLEOTIDES; DEOXYGUANINE NUCLEOTIDES; DNA REPLICATION; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; HUMAN; HYDROGEN-ION CONCENTRATION; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0028062981     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(94)90207-0     Document Type: Article

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