Beta-cell proliferation in normal and streptozotocin-treated newborn rats: site, dynamics and capacity

Diabetologia

Volumn 37, Issue 11, 1994, Pages 1088-1096

  Wang, R N ^a   Bouwens, L ^a   Kloppel G ^a  

^a FREE UNIVERSITY OF BRUSSELS   (Belgium)

Author keywords

beta cell proliferation; immunocytochemistry; morphometry; neonatal rat; Streptozotocin diabetes

Indexed keywords

STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; IMMUNOCYTOCHEMISTRY; MORPHOMETRICS; NEWBORN; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

ANIMAL; ANIMALS, NEWBORN; CELL DIVISION; DIABETES MELLITUS, EXPERIMENTAL; DNA; DNA REPLICATION; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; INSULIN; ISLETS OF LANGERHANS; PANCREATIC DUCTS; PROINSULIN; PROTEIN PRECURSORS; RATS; RATS, WISTAR; REGENERATION; RNA, MESSENGER; STREPTOZOCIN; SUPPORT, NON-U.S. GOV'T;

EID: 0028062752     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/BF00418372     Document Type: Article

References (28)

1. Pancreatic beta-cell growth and diabetes mellitus
2. Pancreatic islet cell regeneration and growth: introduction
3. Genetic factors of importance for β-cell proliferation
4. The role of glucose in the vitro regulation of cell cycle kinetics and proliferation of fetal pancreatic β-cells
5. Functional maturation and proliferation of fetal pancreatic β-cells
6. The development of the endocrine and exocrine pancreas
7. Ontogeny of the endocrine pancreas
8. Development of pancreatic endocrine cell in the rat fetus
9. Ontogenic appearance of immunoreactive endocrine cell in rat pancreatic islets
10. The life story of the pancreatic β cell
11. Histogenesis of the endocrine pancreas in newborn rats after destruction by streptozotocin
12. Ultrastructural study of pancreatic β cell regeneration in newborn rats after destruction by streptozotocin
13. Responses of neonatal rat islets to streptozotocin
14. Limited B cell regeneration in a B cell deficient rat model: studies with dexamethasone
15. Experimental reduction of β-cell mass: implications for the pathogenesis of diabetes
16. Diabetogenic effect of streptozotocin in the rat during the perinatal period
17. Simultaneous immunocytochemical visualization of BrdU and neural tissue antigens
18. The estimation of whole organ volume
19. Digoxigenin as an alterative probe labelling for in situ hybridization
20. Stereological techniques
21. Effect of aging on the regenerative capacity of the pancreatic β-cells of the rat
22. Pancreatic insulin-, glucagon-, and somatostatin-positive islet cell populations during the perinatal development of the rat: I. Morphometric quantitation
23. Changes in the volumes of the A-, B-, and D-cell populations in the pancreatic islets during the postnatal development of the rat
24. Comparison of in situ hybridization and immunocytochemistry for the detection of residual beta-cells in the pancreas of streptozotocin-treated diabetic rats
25. Localization of thyrotropin-releasing hormone- and insulin-immunoreactivity in the pancreas of neonatal rats after injection of streptozotocin at birth
26. Growth of the pancreatic islets in animals