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Bioorganic and Medicinal Chemistry Letters
Volumn 4, Issue 21, 1994, Pages 2559-2562
Solid phase synthesis of trypanothione disulfide
Author keywords

[No Author keywords available]
Indexed keywords

DISULFIDE; SPERMIDINE DERIVATIVE; TRYPANOTHIONE DISULFIDE; UNCLASSIFIED DRUG;
EID: 0028061780     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)80283-3     Document Type: Article
Times cited : (13)
References (17)
  • 4
    • 84908836101 scopus 로고    scopus 로고
    • Abbrevations: Boc, tert.butyloxycarbonyl; BOP, benzotriazol-1-yloxytisdimethylaminophosphonium hexafluorophosphate; DIEA, diisopropylethylamine; DMF, N,N-dimethylformamide; Fmoc, fluorenyl-methoxycarbonyl; HOBt, 1-hydroxybenzotriazole; Trt, trityll Z, benzyloxycarbonyl; Bn, benzyl.
  • 8
    • 84908836100 scopus 로고    scopus 로고
    • 5. The use of the less harmful triphosgene in the last step of the synthesis did not yield the desired product.
  • 14
    • 84908836099 scopus 로고    scopus 로고
    • Chromatographic conditions: a, preparative Nucleosil C18 column (25 × 200 mm). Detection at 250 nm by UV absorbance. The solvent system used was as follows: solvent A was 0.05% TFA in water and solvent B was 50% acetonitrile in solvent A. The product 1 was eluted at 4.9 ml/min with a run of 35 min of solvent A then a linear gradient of 0.11%/min solvent B in solvent A during 90 mm (rt=63.5 min). b) Analytical Nucleosil C18 column (4.6 × 250 mm) with a flow of 0.5 ml/min and a run of 5 min solvent A, then a linear gradient of 3.33%/min solvent B in A.UV detection at 215 nm: dihydrotrypanothione, rt=24.2 min; trypanothione disulfide, rt=23.4 min.
  • 15
    • 84908836098 scopus 로고    scopus 로고
    • Capillary electrophoresis was performed on an Applied Biosystem 270 A-HT apparatus. Separation was carried at 30°C in a 20 mM sodium citrate buffer solution (pH=2.5) with a potential difference of 30 kV. Detection by UV absorbance at 200 nm.
  • 16
    • 84908836097 scopus 로고    scopus 로고
    • 252Cf ionization source. Sample were adsorbed on the nitrocellulose target for analysis.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.