Comparison of Single and Multiple Dose Pharmacokinetics Using Clinical Bioequivalence Data and Monte Carlo Simulations

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 11, Issue 9, 1994, Pages 1330-1336

  El Tahtawy, Ahmed A ^a   Jackson, André J ^a   Ludden, Thomas M ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

absorption rate; bioequivalence; Monte Carlo simulations; steady state bioavailability

Indexed keywords

ERYTHROMYCIN; INDOMETACIN; NIFEDIPINE; PROCAINAMIDE; QUINIDINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; DRUG ABSORPTION; DRUG ELIMINATION; HUMAN; MALE; PHARMACOKINETICS; PRIORITY JOURNAL; SIMULATION;

ADOLESCENT; ADULT; COMPARATIVE STUDY; CROSS-OVER STUDIES; ERYTHROMYCIN; HUMAN; INDOMETHACIN; MALE; MIDDLE AGE; MONTE CARLO METHOD; NIFEDIPINE; PROCAINAMIDE; QUINIDINE; THERAPEUTIC EQUIVALENCY;

EID: 0028060084     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1018906931100     Document Type: Article

References (10)

1. Generic drugs and the prescribing physician
2. Controversy. II Bioequivalence as an indicator of therapeutic equivalence modeling the theoretic influence of bioinequivalence on single-dose drug effect
3. Prediction of steady-state bioequivalence relationships using single dose data I-linear kinetics
4. Single and multiple dose pharmacokinetic evaluation of flutamide in normal geriatric volunteers
5. Multiple-dose pharmacokinetics of nilvadipine in healthy volunteers
6. Single-dose and multiple-dose pharmacokinetics of etintidine in healthy volunteers
7. A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability