Decreased E-Cadherin Expression Is Associated with Poor Prognosis in Patients with Prostate Cancer

Cancer Research

Volumn 54, Issue 14, 1994, Pages 3929-3933

  Schaafsma, H Ewout ^c   Bringuier, Pierre P ^a   Oosterhof, Gosse O N ^a   Debruyne, Frans M J ^a   Schalken, Jack A ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b The Netherlands ^*  (United States)

^c CANISIUS WILHELMINA HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

UVOMORULIN;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER STAGING; CANCER SURVIVAL; CELL ADHESION; CLINICAL TRIAL; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROGNOSIS; PROSTATE CARCINOMA; PROSTATECTOMY; PROTEIN CONTENT;

ADULT; AGED; AGED, 80 AND OVER; CADHERINS; HUMANS; MALE; MIDDLE AGED; PALLIATIVE CARE; PROGNOSIS; PROSTATECTOMY; PROSTATIC NEOPLASMS; SURVIVAL RATE;

EID: 0028058712     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Boring, C.C., Squires, T.S., and Tong, T. Cancer Statistics, 1993. CA Cancer J. Clin., 43: 7-26, 1993.
2. Johansson, J.E., Adami, H.O., Andersson, S.O., Bergström, R., Krusemo, U.B., and Kraaz, W. Natural history of localised prostatic cancer: a population-based study in 223 untreated patients. Lancet, i: 799-803, 1989.
3. Adolfsson, J., Rönströ, L., Carstensen, J., Lowhagen, T., and Hedlund, P.O. The natural course of low grade, non-metastatic prostatic carcinoma. Br. J. Urol., 65: 611-614, 1990.
4. Bostwick, D.G., Graham, S.D., Napalkov, P., Abrahamsson, P.A., di Sant'Agnese, P.A., Algaba, F., Hoisaeter, P.A., Lee, F., Littrup, P., Mostofi, F.K., Denis, L., Schröer, F., and Murphy, G.P. Staging of early prostate cancer: a proposed tumor volume-based prognostic index. Urology, 41: 403-411, 1993.
5. George, N.J.R. Natural history of localised prostatic cancer managed by conservative therapy alone. Lancet, i: 494-497, 1988.
6. Grayhack, J.T., and Assimos, D.G. Prognostic significance of tumor grade and stage in the patient with carcinoma of the prostate. Prostate, 4: 13-31, 1983.
7. Morton, R.A., Steiner, M.S., and Walsh, P.C. Cancer control following anatomical radical prostatectomy: an interim report. J. Urol., 145: 1197-1200, 1991.
8. Takeichi, M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science (Washington DC), 251: 1451-1455, 1991.
9. Marcel, M.M., Behrens, J., Birchmeier, W., De Bruyne, G.K., Vleminckx, K., Hoogewijs, A., Fiers, W.C., and Van Roy, F.M. Down regulation of E-cadherin expression in Madin Darby canine kidney (MDKC) cells inside tumors of nude mice. Int. J. Cancer, 47: 922-928, 1991.
10. Vleminckx, K., Vakaet, L., Jr., Mareel, M., Fiers, W., and Van Roy, F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell, 66: 107-119, 1991.
11. Takeichi, M. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development (Camb.), 102: 639-655, 1988.
12. Frixen, U.H., Behrens, J., Sachs, M., Eberle, G., Voss, B., Warda, A., Löchner, D., and Birchmeier, W. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol., 113: 173-185, 1991.
13. Bussemakers, M.J.G., Van Moorselaar, R.J.A., Giroldi, L.A., Ichikawa, T., Isaacs, J.T., Takeichi, M., Debruyne, F.M.J., and Schalken, J.A. Decreased expression of E-cadherin in the progression of rat prostatic cancer. Cancer Res., 52: 2916-2922, 1992.
14. Umbas, R., Schalken, J.A., Aalders, T.W., Carter, B.S., Karthaus, H.F.M., Schaafsma, H.E., Debruyne, F.M.J., and Isaacs, W.B. Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer. Cancer Res., 52: 5104-5109, 1992.
15. Harmer, M.H. TNM classification of malignant tumours, Ed. 3. Geneva: International Union Against Cancer, 1978.
16. Gleason, D.F. Histologic grading and clinical staging of prostatic carcinoma. In: M. Tannenbaum (ed.), Urologic Pathology: The Prostate, pp. 171-197. Philadelphia: Lea & Febiger, 1977.
17. Schipper, J.H., Frixen, U.H., Behrens, J., Unger, A., Jahnke, K., and Birchmeier, W. E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res., 51: 6328-6337, 1991.
18. Kaplan, E.L., and Meier, P. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc., 53: 457-481, 1958.
19. Shimoyama, Y., and Hirohashi, S. Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma. Cancer Lett., 57: 131-135, 1991.
20. Shimoyama, Y., and Hirohashi, S. Expression of E- and P-cadherin in gastric carcinoma. Cancer Res., 51: 2185-2192, 1991.
21. van der Wurff, A.A.M., Ten Kate, J., Van der Linden, E.P.M., Dinjens, W.N.M., Arends, J.W., and Bosman, F.T. L-CAM expression in normal, premalignant, and malignant colon mucosa. J. Pathol., 168: 287-291, 1992.
22. Inoue, M., Ogawa, H., Miyata, M., Shiozaki, H., and Tanizawa, O. Expression of E-cadherin in normal, benign, and malignant tissues of female genital organs. Am. J. Clin. Pathol., 98: 76-80, 1992.
23. Bringuier, P.P., Umbas, R., Schaafsma, H.E., Karthaus, H.F.M., Debruyne, F.M.J., and Schalken, J.A. Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumors. Cancer Res., 53: 3241-3245, 1993.
24. Mattijssen, V., Peters, H., Schalkwijk, L., Manni, J.J., de Mulder, P.H.M., and Ruiter, D.J. E-cadherin expression in head and neck squamous cell carcinoma. Int. J. Cancer, in press, 1993.
25. Giroldi, L.A., and Schalken, J.A. Decreased expression of the intercellular adhesion molecule E-cadherin in prostate cancer: biological significance and clinical implications. Cancer Metastasis Rev., 12: 29-37, 1993.
26. Shimoyama, Y., Nagafuchi, A., Fujita, S., Gotoh, M., Takeichi, M., Tsukita, S., and Hirohashi, S. Cadherin dysfunction in a human cell line: possible involvement of loss of α-catenin expression in reduced cell-cell adhesiveness. Cancer Res., 52: 57705774, 1992.
27. Morton, R.A., Ewing, C.M., Nagafuchi, A., Tsukita, S., and Isaacs, W.B. Reduction of E-cadherin levels and deletion of the α-catenin gene in human prostate cancer cells. Cancer Res., 53: 3585-3590, 1993.
28. Behrens, J., Vakaet, L., Friis, R., Winterhager, E., Van Roy, F., Mareel, M.M., and Birchmeier, W. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J. Cell Biol., 120: 757-766, 1993.
29. Carter, B.S., Ewing, C.M., Ward, W.S., Treiger, B.F., Aalders, T.W., Schalken, J.A., Epstein, J.I., and Isaacs, W.B. Allelic loss of chromosomes 16q and lOq in human prostate cancer. Proc. Natl. Acad. Sci. USA, 87: 8751-8755, 1990.
30. Bergerheim, U.S.R., Kunimi, K., Collins, V.P., and Ekman, P. Deletion mapping of chromosomes 8, 10, and 16 in human prostatic carcinoma. Genes Chromosomes Cancer, 3: 215-220, 1991.
31. Risinger, J.I., Kohler, M.F., Berchuck, A., and Boyd, J. Mutation of the E-cadherin gene in endometrial carcinoma. Proc. Am. Assoc. Cancer Res., 34: 540, 1993.
32. Becker, K.F., Atkinson, M.J., Reich, U., Huang, H.H., Nekarda, H., Siewert, J.R., and Hdfler, H. Exon skipping in the E-cadherin gene transcript in metastatic human gastric carcinomas. Hum. Mol. Genet., 2: 803-804, 1993.