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Volumn 263, Issue 5145, 1994, Pages 380-384

Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors

(15) Lam, Patrick Y S a Jadhav, Prabhakar K a Eyermann, Charles J a Hodge, C Nicholas a Ru, Yu a Bacheler, Lee T a Meek, James L a Otto, Michael J a Rayner, Marlene M a Wong, Y Nancy a Chang, Chong Hwan a Weber, Patricia C a Jackson, David A a Sharpe, Thomas R a Erickson Viitanen, Susan a

a DUPONT COMPANY (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CYCLIC UREA DERIVATIVE; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BIOAVAILABILITY; DRUG DESIGN; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ADMINISTRATION, ORAL; ANIMAL; AZEPINES; BINDING SITES; BIOLOGICAL AVAILABILITY; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DOGS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR WEIGHT; RATS; RECOMBINANT PROTEINS; SUPPORT, NON-U.S. GOV'T; UREA; VIRUS REPLICATION;

EID: 0028057975 PISSN: 00368075 EISSN: None Source Type: Journal
DOI: 10.1126/science.8278812 Document Type: Article

Times cited : (923)

References (65)

1
- 0025130997
- (1990) Trends Biochem. Sci. , vol.15 , pp. 425
- Blundell, T.L.¹

2
- 77956796531
- (1991) Annu. Rep. Med. Chem. , vol.26 , pp. 141
- Norbeck, D.W.¹ Kempf, D.J.²

3
- 85027773525
- (1991) Chim. Oggi , vol.6
- Tomasselli, A.G.¹

4
- 0026579208
- (1992) AIDS Res. Hum. Retroviruses , vol.8 , pp. 153
- Debouck, C.¹

5
- 0026561407
- (1992) Antiviral Res. , vol.17 , pp. 265
- Martin, J.A.¹

6
- 0027314693
- (1993) Trends Pharmacol. Sci. , vol.14 , pp. 196
- Yarchoan, R.¹ Mitsuya, H.² Broder, S.³

7
- 0026658493
- (1992) Bioorg. Med. Chem. Lett. , vol.2 , pp. 541
- Babine, R.E.¹

8
- 0026666539
- (1992) J. Am. Chem. Soc. , vol.114 , pp. 7604
- Ikeda, S.¹ Askley, J.A.² Winsching, P.³ Janda, K.D.⁴

9
- 0026483378
- (1992) J. Med. Chem. , vol.35 , pp. 3803
- Rich, D.H.¹

10
- 0027410562
- (1993) J. Med. Chem. , vol.36 , pp. 292
- Ghosh, A.K.¹

11
- 85027799429
- J. Med. Chem. , pp. 288
- Getman, D.P.¹

12
- 0027398520
- (1993) J. Am. Chem. Soc. , vol.115 , pp. 801
- Thompson, W.J.¹

13
- 0027481382
- (1993) Biocrg. Med. Chem. Lett. , vol.3 , pp. 503
- Holmes, D.S.¹

14
- 0027405931
- (1993) J. Med. Chem. , vol.36 , pp. 320
- Kempf, D.J.¹

15
- 85027827608
- (1992) Proceedings of the British Pharmacological Society , pp. 170
- Muirhead, G.J.¹

16
- 85027813913
- Proceedings of the British Pharmacological Society , pp. 156
- Williams, P.E.O.¹ Muirhead, G.J.² Madigan, M.J.³ Mitchell, A.M.⁴ Shaw, T.⁵

17
- 85027779542
- Proceedings of the British Pharmacological Society , pp. 167
- Shaw, T.M.¹ Muirhead, G.J.² Parish, N.³ McClelland, G.R.⁴ Houston, A.C.⁵

18
- 0002340017
- C.R. Clark and W.H. Moos, Eds. (Ellis Horwood, Chichester, England
- (1990) Drug Discovery Technologies , pp. 92-126
- Plattner, J.J.¹ Norbeck, D.W.²

19
- 0025360877
- (1990) Med. Res. Rev. , vol.10 , pp. 173
- Greenlee, W.J.¹

20
- 0027396090
- (1993) J. Med. Chem. , vol.36 , pp. 449
- Rosenberg, S.H.¹

21
- 0026698259
- (1992) Science , vol.257 , pp. 1940
- Kleinert, H.D.¹

22
- 85027760782
- (1991) PCT Patent Application WO , vol.91 , Issue.18 , pp. 866A
- Jadhav, P.K.¹ McGee, L.R.² Shenvi, A.³ Hodge, C.N.⁴

23
- 0026756670
- (1992) Bioorg. Med. Chem. Lett. , vol.2 , pp. 353
- Jadhay, P.K.¹ Woerner, F.J.²

24
- 85027827322
- (1992) Vilith Int. Conf. AIDS Amsterdam , vol.1 , pp. 203
- Otto, M.J.¹

25
- 0020491251
- (1982) J. Mol. Biol. , vol.161 , pp. 269
- Kuntz, I.D.¹ Blaney, J.M.² Oatley, S.J.³ Langridge, R.⁴ Ferrin, T.E.⁵

26
- 0025054246
- (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 6644
- DesJarlais, R.L.¹

27
- 0024725804
- (1989) J. Comput.-Aided Mol. Des. , vol.3 , pp. 225
- VanDrie, J.H.¹ Weininger, D.² Martin, Y.C.³

28
- 0041786443
- (1990) Tetrahedron Comput. Methodol. , vol.3 , pp. 673
- Bures, M.G.¹

29
- 85027749364
- (1993) PCT Patent Application WO 9307128
- Lam, P.Y.S.¹ Eyermann, C.J.² Hodge, C.N.³ Jadhav, P.K.⁴ Delucca, G.V.⁵

30
- 0024412506
- (1989) Science , vol.245 , pp. 616
- Wlodawer, A.¹

31
- 0024992935
- (1990) Science. , vol.249 , pp. 527
- Erickson, J.¹

32
- 20244373125
- (1989) Nature , vol.342 , pp. 299
- Lapatto, R.¹

33
- 0024344021
- (1989) Science , vol.246 , pp. 1149
- Miller, M.¹

34
- 0025108755
- (1990) J. Biol. Chem. , vol.265 , pp. 14209
- Fitzgerald, P.M.D.¹

35
- 0025829331
- (1991) Biochemistry , vol.30 , pp. 1600
- Jaskolski, M.¹

36
- 0026663760
- (1992) Biochemistry. , vol.31 , pp. 6646
- Dreyer, G.¹

37
- 0026720077
- (1992) J. Med. Chem. , vol.35 , pp. 2525
- Tucker, T.J.¹

38
- 0026350729
- (1992) J. Am. Chem. Soc. , vol.113 , pp. 9382
- Bone, R.¹ Vacca, J.² Anderson, P.S.³ Holloway, M.K.⁴

39
- 0027218692
- (1993) Annu. Rev. Biochem. , vol.62 , pp. 543
- Wlodawer, A.¹ Erickson, J.²

40
- 0025225682
- (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 8805
- Swain, A.L.¹

41
- 0025122828
- (1990) FEBS Lett. , vol.269 , pp. 269
- Gutschina, A.¹ Weber, I.T.²

42
- 0026788012
- (1992) Biochemistry , vol.31 , pp. 9857
- Timasheff, S.N.¹

43
- 0027411473
- (1993) Biochemistry. , vol.32 , pp. 937
- Dreyer, G.B.¹

44
- 0027081927
- (1992) Protein Sci. , vol.1 , pp. 1061
- Thanki, N.¹

45
- 6744267941
- DGEOM, Quantum Chemistry Program Exchange , vol.590
- Blaney, J.M.¹ Crippen, G.M.² Dearing, A.³ Dixon, J.S.⁴

46
- 85027758342
- W. Warr, Ed. (Springer-Verlag, Heidelberg, Germany
- (1993) Proceedings of the 2nd International Conference on Chemical Information , pp. 303-314
- Ripka, W.C.¹ Eyermann, C.J.²

47
- 0026642983
- (1992) J. Med. Chem. , vol.35 , pp. 2145
- Martin, Y.C.¹

48
- 0041936278
- (1991) J. Chem. Inf. Comput. Sci. , vol.31 , pp. 187
- Allen, F.H.¹

49
- 77957056968
- (1974) Cryst. Struct. Commun. , vol.3 , pp. 145
- Andreetti, G.D.¹ Bocelli, G.² Sgarabotto, P.³

50
- 0024588901
- (1989) Science , vol.243 , pp. 85
- Weber, P.C.¹ Ohlendorf, D.H.² Wendoloski, J.J.³ Salemme, F.R.⁴

51
- 0010314045
- (1986) Tetrahedron , vol.42 , pp. 1607
- Cram, D.J.¹ Lam, P.Y.S.²

52
- 33845471761
- (1984) J. Am. Chem. Soc. , vol.106 , pp. 7150
- Cram, D.J.¹ Dicker, I.B.² Lauer, M.³ Knobler, C.B.⁴ Trueblood, K.N.⁵

53
- 0024279870
- (1988) Science , vol.240 , pp. 760
- Cram, D.J.¹

54
- 33845378119
- (1985) J. Am. Chem. Soc. , vol.107 , pp. 3657
- Cram, D.J.¹ Lein, G.M.²

55
- 85027762340
- in press
- Antiviral Chem. Chemother.
- Bacheler, L.¹

56
- 0027464122
- (1993) Antiviral Chem. Chemother. , vol.4 , pp. 27
- Smallheer, J.M.¹

57
- 0026043144
- (1991) Arch. Virol. , vol.120 , pp. 71
- Schatzl, H.¹ Gelderblom, H.R.² Nitschko, H.³ vonder Helm, K.⁴

58
- 0017411710
- (1977) J. Mol. Biol. , vol.112 , pp. 535
- Bernstein, F.¹

59
- 0026700747
- (1992) AIDS , vol.6 , pp. 1069
- Iwakura, Y.¹

60
- 0027497412
- (1993) J. Acq. Immune Defic. Syndr. , vol.6 , pp. 24
- Lai, M.-H.T.¹

61
- 0027231438
- (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 4713
- Dueweke, T.J.¹

62
- 85027810719
- Proc. Natl. Acad. Sci. U.S.A. , pp. 5633
- Tisdale, M.¹ Kemp, S.D.² Parry, N.R.³ Larder, B.A.⁴

63
- 85027787360
- paper presented at Noordwijk, The Netherlands, 3 to 5 June
- (1993) 2nd International Workshop on HIV Drug Resistance
- Otto, M.J.¹

64
- 0025641617
- (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 9660
- Cheng, Y.S.E.¹

65
- 0024784403
- (1989) AIDS Res. Hum. Retroviruses , vol.5 , pp. 577
- Erickson-Viitanen, S.¹

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