Efficient Synthesis of Losartan, A Nonpeptide Angiotensin II Receptor Antagonist

Journal of Organic Chemistry

Volumn 59, Issue 21, 1994, Pages 6391-6394

  Larsen, Robert D ^a   King, Anthony O ^a   Chen, Cheng Y ^a   Corley, Edward G ^a   Foster, Bruce S ^a   Roberts, F Edward ^a   Yang, Chunhua ^a   Lieberman, David R ^a   Reamer, Robert A ^a   Tschaen, David M ^a   Verhoeven, Thomas R ^a   Reider, Paul J ^a   Young, S Lo ^b   Rossano, Lucius T ^b   Brookes, Sidney ^b   Meloni, David ^b   Moore, James R ^b   Arnett, John F ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN II ANTAGONIST; LOSARTAN; PEPTIDE HORMONE ANTAGONIST;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0028054343     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo00100a048     Document Type: Article

References (20)

1. Duncia, J. V.; Chiu, A. T.; Carini, D. J.; Gregory, G. B.; Johnson, A. L.; Price, W. A.; Wells, G. J.; Wong, P. C.; Calabrese, J. C.; Timmermans, P. B. M. W. M. J. Med. Chem. 1990, 33, 1312
2. Wyvratt, M. J.; Patchett, A. A. Med. Res. Rev. 1985, 5, 483
3. Duncia, J. V.; Pierce, M. E.; Santella, J. B., III. J. Org. Chem. 1991, 56, 2395
4. Carini, D. J.; Duncia, J. V.; Aldrich, P. E.; Chiu, A. T.; Johnson, A. L.; Pierce, M. E.; Price, W. A.; Santella, J. B., III; Wells, G. J.; Wexler, R. R.; Wong, P. C.; Yoo, S.-E.; Timmermans, P. B. M. W. M. J. Med. Chem. 1991, 34, 2525
5. Duncia, J. V.; Carini, D. J.; Chiu, A. T.; Johnson, A. L.; Price, W. A.; Wong, P. C.; Wexler, R. R.; Timmermans, P. B. M. W. M. Med. Res. Rev. 1992, 12, 149
6. Negishi, E.; King, A. O.; Okukado, N. J. Org. Chem. 1977, 42, 1821
7. Mantlo, N. B.; Chakravarty, P. K.; Ondeyka, D. L.; Siegl, P. K. S.; Chang, R. S.; Lotti, V. J.; Faust, K. A.; Chen, T.-B.; Schorn, T. W.; Sweet, C. S.; Emmert, S. E.; Patchett, A. A.; Greenlee, W. J. J. Med. Chem. 1991, 34, 2922
8. Carini, D. J.; Duncia, J. V.; Aldrich, P. E.; Chiu, A. T.; Johnson, A. L.; Pierce, M. E.; Price, W. A.; Santella, J. B.; Wells, G. J.; Wexler, R. R.; Wong, P. C.; Yoo, W.-E.; Timmermans, P. B. M. W. M. J. Med. Chem. 1991, 34, 2525
9. Russel, R. K.; Murray, W. V. J. Org. Chem. 1993, 58, 5023
10. Watson, S. P. Synth. Commun. 1992, 22, 2971
11. Shi, Y. J.; Frey, L. F.; Tschaen, D. M.; Verhoeven, T. R. Synth. Commun. 1993, 23, 2623
12. Sharp, M. J.; Snieckus, V. Tetrahedron Lett. 1985, 26, 5997
13. Alo, B. I.; Kandil, A.; Patil, P. A.; Sharp, M. J.; Siddiqui, M. A.; Snieckus, V. J. Org. Chem. 1991, 56, 3763
14. Unrau, C. M.; Campbell, M. G.; Snieckus, V. Tetrahedron Lett. 1992, 33, 2773
15. Miyaura, N.; Ishiyama, T.; Sasaki, H.; Ishikawa, M.; Satoh, M.; Suzuki, A. J. Am. Chem. Soc. 1989, 111, 314
16. Suzuki, A. Pure Appl. Chem. 1991, 63, 419
17. Kalinin, V. N. Synthesis 1992, 413
18. Snieckus, V. Chem. Rev. 1990, 90, 879
19. Schuman, R. F.; King, A. O.; Anderson, R. K. U.S. Patent 5,039,814, 1991
20. Flippin, L. Tetrahedron Lett. 1991, 32, 6857