-
1
-
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0024425887
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Checkpoints: controls that ensure the order of cell cycle events
-
(1989)
Science
, vol.246
, pp. 629-634
-
-
Hartwell1
Weinert2
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2
-
-
0026703325
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Creative blocks: cell cycle checkpoints and feedback controls
-
(1992)
Nature
, vol.359
, pp. 599-604
-
-
Murray1
-
4
-
-
0025778595
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Coupling M phase and S phase: controls maintaining the dependence of mitosis on chromosome replication
-
(1991)
Cell
, vol.65
, pp. 921-923
-
-
Enoch1
Nurse2
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5
-
-
0027496670
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Escherichia coli cell division
-
of special interest, Review of cell division in E. coli concentrating on the control of septation by the FtsZ protein.
-
(1993)
Curr Opin Genet Dev
, vol.3
, pp. 783-788
-
-
Lutkenhaus1
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9
-
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0027731971
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Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
-
of outstanding interest, This paper (and [7 of outstanding interest, 8 of outstanding interest]) describes 3 different routes to the discovery of the 21 kDa Cdk inhibitor that appears to mediate the ability of p53 to prevent entry into S phase in cells that have sustained DNA damage.
-
(1993)
Nature
, vol.366
, pp. 707-710
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-
Gu1
Turck2
Morgan3
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10
-
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0021616838
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UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
-
(1984)
Mol Cell Biol
, vol.4
, pp. 1689-1694
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-
Maltzman1
Czyzyk2
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13
-
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0027332996
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Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?
-
of outstanding interest, A careful study of p53 levels after treating normal, Bloom's syndrome, xeroderma pigmentosum and ataxia telangiectasia fibroblasts with UV or X-rays. The kinetics of p53 accumulation in response to X-rays and UV differ, and the only mutant cell lines that show an altered response are a minority of the Bloom's syndrome lines.
-
(1993)
Cell
, vol.75
, pp. 765-778
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-
Lu1
Lane2
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15
-
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0027244234
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Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
-
of special interest, This paper presents evidence that physical sequestration of Wee1, the tyrosine kinase that prevents the activation of Cdc2, in the nucleus allows cells to inactivate Cdc2-cyclin complexes in the nucleus without affecting the activity of those in the cytoplasm.
-
(1993)
Cell
, vol.74
, pp. 463-474
-
-
Heald1
McLoughlin2
McKeon3
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17
-
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0026610360
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CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae
-
(1992)
Nature
, vol.355
, pp. 368-371
-
-
Amon1
Surana2
Muroff3
Nasmyth4
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18
-
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0026009964
-
Feedback control of mitosis in budding yeast
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(1991)
Cell
, vol.66
, pp. 519-531
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-
Li1
Murray2
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19
-
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0025941405
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S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
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(1991)
Cell
, vol.66
, pp. 507-517
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-
Hoyt1
Trotis2
Roberts3
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20
-
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0027184779
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The S. pombe cdc16 gene is required both for maintenance of p34cdc2 kinase activity and regulation of septum formation: a link between mitosis and cytokinesis?
-
of special interest, This paper provides a demonstration that similar components are used in the spindle assembly checkpoint in fission and budding yeast. Note that the cdc16 gene is essential in fission yeast, but its apparent homolog, BUB2, is not essential in budding yeast.
-
(1993)
EMBO J
, vol.12
, pp. 2697-2704
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Fankhauser1
Marks2
Reymond3
Simanis4
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21
-
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0028134981
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A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts.
-
of special interest, in press, This paper makes two useful points: like unreplicated DNA, unassembled spindles can only arrest the embryonic frog cell cycle when they are present at high concentrations, and the initiation and maintenance of this arrest is dependent on the activation of Erk2, a member of the MAP kinase family.
-
(1994)
Cell
-
-
Minshull1
Sun2
Tonks3
Murray4
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22
-
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0027303640
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Differential expression of a phosphoepitope at the kinetochores of moving chromosomes
-
of outstanding interest, This paper reports the identification of an immunochemical marker for kinetochores that are not stably attached to the mitotic spindle, providing the first biochemical sign that kinetochores that have not attached to microtubules can activate the spindle assembly checkpoint.
-
(1993)
J Cell Biol
, vol.122
, pp. 1311-1321
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-
Gorbsky1
Ricketts2
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23
-
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0014594112
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Chromosome manipulation III. Induced reorientation and the experimental control of segregation in meiosis
-
(1969)
J Cell Biol
, vol.43
, pp. 40-50
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-
Nicklas1
Koch2
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24
-
-
84911313074
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The checkpoint control for the metaphase to anaphase transition in vertebrate somatic cells monitors kinetochore attachement to the spindle
-
of outstanding interest, in press, The first clear demonstration that single kinetochores that have not yet attached to microtubules can delay the onset of anaphase. (See also [32 of outstanding interest].)
-
(1994)
J Cell Biol
-
-
Rieder1
Schultz2
Cole3
Sluder4
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26
-
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0027360552
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Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations
-
of special interest, Low doses of the microtubule stabilizing drug taxol can arrest cells in mitosis without changing the amount of microtubule polymer inside cells.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 9552-9556
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-
Jordan1
Toso2
Thrower3
Wilson4
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27
-
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0027462041
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Mitotic block in HeLa cells by vinblastine: ultrastructural changes in kinetochore-microtubule attachment and in centrosomes
-
of outstanding interest, Electron microscopy of cells arrested in mitosis by low doses of the polymerization inhibitor vinblastine shows that, even though these doses do not change the total amount of microtbule polymer in the spindle, they reduce the number of microtubules bound to each kinetochore.
-
(1993)
J Cell Sci
, vol.104
, pp. 261-274
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-
Wendell1
Wilson2
Jordan3
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29
-
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0028287114
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CENP-C is required for maintaining proper kinetochore size and for a timely transition to anaphase
-
of special interest, Microinjection of antibodies against a kinetochore component leads to mitotic arrest. Note that this effect occurs only when antibodies are injected well in advance of entry into mitosis, suggesting that CENP-C is required for kinetochore assembly rather than kinetochore function.
-
(1994)
J Cell Biol
, vol.125
, pp. 531-545
-
-
Tomkiel1
Cooke2
Saitoh3
Bernat4
Earnshaw5
-
32
-
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0028229269
-
Feedback control of the metaphase-anaphase transition in sea urchin zygotes: role of maloriented chromosomes
-
of outstanding interest, Failure of half of the chromosomes to attach to the spindle does not delay anaphase in sea urchin embryos. In conjunction with [24 of outstanding interest], this work shows that different cells must monitor different features of the mitotic spindle.
-
(1994)
J Cell Biol
, vol.126
, pp. 189-198
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-
Sluder1
Miller2
Thompson3
Wolf4
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33
-
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0022273637
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Experimental analysis of the reproduction of spindle poles
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(1985)
J Cell Sci
, vol.76
, pp. 35-51
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Sluder1
Begg2
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34
-
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0025039420
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Daughterless-abo-like, a Drosophila maternal effect mutation that exhibits abnormal centrosome separation during the late blastoderm divisions
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(1990)
Development
, vol.110
, pp. 311-323
-
-
Sullivan1
Minden2
Alberts3
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35
-
-
0027264596
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Mutations affecting the cytoskeletal organization of syncytial Drosophila embryos
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of special interest, Mutations that lead to mitotic abnormalities in Drosophila embryos cause affected nuclei to fall from the surface of the egg.
-
(1993)
Development
, vol.118
, pp. 1245-1254
-
-
Sullivan1
Fogarty2
Theurkauf3
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36
-
-
0027442202
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Delays in anaphase initiation occur in individual nuclei of the syncytial Drosophila embryo
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of special interest, Doubling the size of one chromosome causes mitotic delays in the early Drosophila embryo that ultimately lead to elimination of the delayed nuclei from development.
-
(1993)
Mol Biol Cell
, vol.4
, pp. 885-896
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-
Sullivan1
Daily2
Fogarty3
Yook4
Pimpinelli5
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37
-
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0017126746
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Division and migration of nuclei during early embryogenesis of Drosophila melanogaster
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(1976)
J Microbiol Cell
, vol.25
, pp. 97-106
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-
Zalokar1
Erk2
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38
-
-
0025284348
-
Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: studies in Xenopus
-
(1990)
Cell
, vol.61
, pp. 811-823
-
-
Dasso1
Newport2
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40
-
-
0027319521
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p53 is required for radiation-induced apoptosis in mouse thymocytes
-
of outstanding interest, This paper and [39 of outstanding interest] provide the initial demonstrations that p53 is required for DNA damage induced apoptosis, but not for apoptosis induced by glucocorticoids, which probably mimic thymic selection of T cells.
-
(1993)
Nature
, vol.362
, pp. 847-849
-
-
Lowe1
Schmitt2
Smith3
Osborne4
Jacks5
-
42
-
-
0025651121
-
Disruption of microtubules induces an endogenous suicide pathway in human leukaemia HL-60 cells
-
(1990)
Cell Tissue Kinet
, vol.23
, pp. 545-559
-
-
Martin1
Cotter2
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45
-
-
0027451668
-
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
-
of outstanding interest, The efficient induction of apoptosis in fibroblasts requires the presence of both an activated oncogene and of p53. The much more efficient induction of apoptosis in oncogene-expressing cells provides an important clue as to how DNA damaging agents and general inhibitors of DNA replication and mitosis can selectively kill some tumor cells.
-
(1993)
Cell
, vol.74
, pp. 957-967
-
-
Lowe1
Ruley2
Jacks3
Housman4
-
47
-
-
0028323294
-
Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells
-
of special interest, A demonstration that the adenovirus E1A oncogene kills wild-type cells, but transforms p53-deficient cells.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 2026-2030
-
-
Lowe1
Jacks2
Housman3
Ruley4
-
50
-
-
0028347698
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Influence of immunoglobulin heavy- and light-chain expression on B cell differentiation
-
of outstanding interest, This paper and [49 of outstanding interest] show that failures in specific steps of antibody gene rearrangement lead to specific blocks at different stages of B-cell development.
-
(1994)
Genes Dev
, vol.8
, pp. 1043-1057
-
-
Young1
Ardman2
Shinkai3
Lansford4
Blackwell5
Mendelsohn6
Rolink7
Melchers8
Alt9
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