Novel benzodioxopiperazines acting as antagonists at postsynaptic 5- HT(1A) receptors and as agonists at 5-HT(1A) autoreceptors: A comparative pharmacological characterization with proposed 5-HT(1A) antagonists

Journal of Pharmacology and Experimental Therapeutics

Volumn 268, Issue 1, 1994, Pages 337-352

  Millan, M J ^a   Canton, H ^a   Gobert, A ^a   Lejeune, F ^a   Rivet, J M ^a   Bervoets, K ^a   Brocco, M ^a   Widdowson, P ^a   Mennini, T ^a   Audinot, V ^a   Honore, P ^a   Renouard, A ^a   Le Marouille Girardon, S ^a   Verriele, L ^a   Gressier, H ^a   Peglion, J L ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1,4 BENZODIOXAN 5 YL) 4 (2 INDANYL)PIPERAZINE; 1 (1,4 BENZODIOXAN 5 YL) 4 (INDAN 2 YL)PIPERAZINE; 1 (1,4 BENZODIOXAN 5 YL) 4 [2 (1 INDANYL)ETHYL]PIPERAZINE; 1 (1,4 BENZODIOXAN 5 YL) 4 [2 (INDAN 1 YL)ETHYL]PIPERAZINE; 1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 1 [2 (BENZOCYCLOBUTAN 1 YL)ETHYL] 4 (1,4 BENZODIOXAN 5 YL)PIPERAZINE; 4 [4 [4 (1,1,3 TRIOXO 2H 1,2 BENZISOTHIAZOL 2 YL)BUTYL] 1 PIPERAZINYL] 1H INDOLE 2 CARBOXYLIC ACID METHYL ESTER; 8 [2 [(2,3 DIHYDRO 1,4 BENZODIOXIN 2 YL)METHYLAMINO]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE MESYLATE; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ADRENERGIC RECEPTOR; ALPRENOLOL; AUTORECEPTOR; DOPAMINE RECEPTOR; ELTOPRAZINE; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; PIPERAZINE DERIVATIVE; POSTSYNAPTIC RECEPTOR; S 14489; SEROTONIN RECEPTOR; SPIPERONE; TERTATOLOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG SELECTIVITY; LIGAND BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADMINISTRATION, ORAL; ANIMAL; COMPARATIVE STUDY; CORPUS STRIATUM; CROSS-LINKING REAGENTS; DIOXANES; GUINEA PIGS; IN VITRO; MALE; NEURONS; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC; RECEPTORS, DOPAMINE; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SYNAPSES;

EID: 0028053247     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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