Fish Oil, Alcohol, and Liver Pathology: Role of Cytochrome P450 2E1

Proceedings of the Society for Experimental Biology and Medicine

Volumn 207, Issue 2, 1994, Pages 197-205

  Morimoto, M ^a   Zern, M A ^b   Hagbjork A L ^c   Ingelman Sundberg, M ^a   French, S W ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; CORN OIL; CYTOCHROME P450 ISOENZYME; CYTOCHROME P450 REDUCTASE; FISH OIL; GLUCOSE; LINOLEIC ACID; LIVER ENZYME; MENHADEN OIL; POLYUNSATURATED FATTY ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; FATTY LIVER; HEPATITIS; LIPID DIET; LIPID PEROXIDATION; LIVER FIBROSIS; LIVER INJURY; LIVER MICROSOME METABOLISM; LIVER NECROSIS; LIVER WEIGHT; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; WEIGHT GAIN;

ALANINE TRANSAMINASE; ANIMAL; CORN OIL; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; ETHANOL; FISH OILS; LIPID PEROXIDATION; LIVER; MALE; NADP; OXIDATION-REDUCTION; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028051780     PISSN: 00379727     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/00379727-207-43807     Document Type: Article

References (39)

1. A diet rich in omega 3 fatty acids (ω-3FA) induced liver injury in rats, G. Annoni, M.A. Giambrone, L. Biempica, L. Scharschmidt, M.A. Zern, Hepatology, 1988, 8
2. Improved rat model of alcoholic liver disease: Omega-3 fatty acids (ω3 FAs) plus ethanol administration, S. Degli Esposito, O. Frizell, Q. He, A. Abraham, S.W. French, M.A. Zern, Hepatology, 1991, 14
3. Nutrition in the pathogenesis of alcoholic liver disease, S.W. French, Alcohol Alcoholism, 1993, 28, 97-109
4. Hepatic lipid peroxidation and mitochondrial susceptibility to peroxidative attacks during ethanol inhalation and withdrawal, H. Rouach, M. Clement, M.-T. Orfanelli, B. Janvier, J. Nordmann, R. Nordmann, Biochim Biophys Acta, 1983, 753, 439-444
5. Effect of prolonged alcohol administration on activities of various enzymes scavenging activated oxygen radicals and lipid peroxide level in the liver of rats, J. Harata, M. Nagata, E. Sasaki, I. Ishiguro, Y. Ohta, Y. Murakami, Biochem Pharmacol, 1983, 32, 1798-1800
6. Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochrome P-450, M. Ingelman-Sundberg, I. Johansson, J Biol Chem, 1984, 259, 6447-6458
7. Centrilobular expression of ethanol-inducible cytochrome P450 (IIE1) in rat liver, M. Ingelman-Sundberg, I. Johansson, K.E. Penttila, H. Glaumann, K.O. Lindros, Biochem Biophys Res Commun, 1988, 157, 55-60
8. Lipid peroxidation dependent on ethanol-inducible cytochrome P-450 from rat liver, M. Ingelman-Sundberg, G. Ekström, N. Tindberg, Adv Biosci, 1988, 71, 43-47
9. Lipid peroxidation and antioxidant defense systems in rat liver after chronic ethanol feeding, T. Kawase, S. Kato, C.S. Lieber, Hepatology, 1989, 10, 815-821
10. The intralobular distribution of ethanol-inducible P450 IIE1 in rat and human liver, M. Tsutsumi, J.M. Lasker, M. Shimizu, A.S. Rosman, C.S. Lieber, Hepatology, 1989, 10, 437-446
11. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450 IIE1), G. Ekström, M. Ingelman-Sundberg, Biochem Pharmacol, 1989, 38, 1313-1319
12. Increase in lipoperoxides and prolyl hydroxylase activity in rat liver following chronic ethanol feeding, S. Yamada, M. Yamada, Y. Murawaki, C. Hirayama, Biochem Pharmacol, 1990, 40, 1015-1019
13. Role of ethanol-inducible cytochrome P-450 (P450IIE1) in catalyzing the free radical activation of aliphatic alcohols, E. Albano, A. Tomasi, J.-O. Persson, Y. Terelius, L. Goria-Gatti, M. Ingelman-Sundberg, M.U. Dianzani, Biochem Pharmacol, 1991, 41, 1895-1902
14. Effects of dietary fat composition on activities of the microsomal ethanol-inducible cytochrome P450 (CYP2E1) in the liver of rats chronically fed ethanol, H. Takahashi, I. Johansson, S.W. French, M. Ingelman-Sundberg, Pharmacol Toxicol, 1992, 70, 347-352
15. Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: association of lipid peroxidation with liver fibrogenesis, S. Kamimura, K. Gaal, R.S. Britton, B.R. Bacon, G. Triadafilopoulos, H. Tsukamoto, Hepatology, 1992, 16, 448-453
16. Dietary effects on cytochromes P450, xenobiotic metabolism, and toxicity, C.S. Yang, J.F. Brady, J.-Y. Hong, FASEB J, 1992, 6, 737-744
17. Effect of ethanol on cytochrome P450 2E1 (CYP2E1), lipid peroxidation, and serum protein adduct formation in relation to liver pathology pathogenesis, S.W. French, K. Wong, L. Jui, E. Albano, A.-L. Hagbjork, M. Ingelman-Sundberg, Exp Mol Pathol, 1993, 58, 61-75
18. Role of cytochrome P450 2E1 in alcoholic liver disease pathogenesis, M. Morimoto, A.-L. Hagbjork, A.A. Nanji, M. Ingelman-Sundberg, K.O. Lindros, P.C. Fu, E. Albano, S.W. French, Alcohol, 1993, 10, 459-464
19. In vivo induction of heptic P450 2E1 by ethanol: Role of increased enzyme synthesis, M. Tsutsumi, J.M. Lasker, T. Takahashi, C.S. Lieber, Arch Biochem Biophys, 1993, 304, 209-218
20. Effects of chronic ethanol on growth hormone secretion and hepatic cytochrome P450 isozymes of the rat, T.M. Badger, M.J.J. Ronis, C.K. Lumpkin, C.R. Valentine, M. Shahare, D. Irby, J. Huang, C. Mercado, P. Thomas, M. Ingelman-Sundberg, J. Crouch, J Pharmacol Exp Ther, 1993, 264, 438-447
21. Changes in microsomal phospholipases and arachidonic acid in experimental alcoholic liver injury: Relationship to cytochrome P-450 2E1 induction and conjugated diene formation, A.A. Nanji, S. Zhao, R.G. Lamb, S.M.H. Sadrzadeh, A.J. Dannenberg, D.J. Waxman, Alcoholism Clin Exp Res, 1993, 17, 598-603
22. Induction of cytochrome P450 2E1 during chronic ethanol exposure occurs via transcription of the CYP 2E1 gene when blood alcohol concentrations are high, T.M. Badger, J. Huang, M. Ronis, C.K. Lumpkin, Biochem Biophys Res Commun, 1993, 190, 780-785
23. Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentrations in rats, M.J.J. Ronis, J. Huang, J. Crouch, C. Mercado, D. Irby, C.R. Valentine, C.K. Lumpkin, M. Ingelman-Sundberg, T.M. Badger, J Pharmacol Exp Ther, 1993, 264, 944-950
24. Induction of cytochrome P-450 2E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA, T. Takahashi, J.M. Lasker, A.S. Rosman, C.S. Lieber, Hepatology, 1993, 17, 236-245
25. Effect of dietary lipids and vitamin E on in vitro lipid peroxidation in rat liver and kidney homogenates, M.-L. Hu, E.N. Frankel, B.E. Leibovitz, A.L. Tappel, J Nutr, 1989, 119, 1574-1582
26. Regulation of hepatic microsomal cytochrome P450 IIE1 level by dietary lipids and carbohydrates in rats, J.-S.H. Yoo, S.M. Ning, C.B. Pantuck, E.J. Pantuck, C.S. Yang, J Nutr, 1991, 121, 959-965
27. Effect of long-term fish oil supplementation on vitamin E status and lipid peroxidation in women, M. Meydani, F. Natiello, B. Goldin, N. Free, M. Woods, E. Schaefer, J.B. Blumberg, S.L. Gorbach, J Nutr, 1991, 121, 484-491
28. The effects of fish oil on triglycerides, cholesterol, fibrogen and malondialdehyde in humans supplemented with vitamin E, O. Haglund, R. Luostarinen, R. Wallin, L. Wibell, T. Saldeen, J Nutr, 1991, 121, 165-169
29. Dietary (n-3) fatty acids affect rat heart, liver and aorta protective enzyme activities and lipid peroxidation, M.R. L'Abbe, K.D. Trick, J.L. Beare-Rogers, J Nutr, 1991, 121, 1331-1340
30. Lipid peroxidation products are elevated in fish oil diets even in the presence of added antioxidants, M.J. Gonzalez, J.I. Gray, R.A. Schemmel, L. Dugan, Jr., C.W. Welsch, J Nutr, 1992, 122, 2190-2195
31. (n-3) Fatty acids, tissue lipid peroxidation and tocopherol status, M. Meydani, S.N. Meydani, J Nutr, 1992, 122, 1748
32. Beef fat prevents alcoholic liver disease in the rat, A.A. Nanji, C.L. Mendenhall, S.W. French, Alcoholism Clin Exp Res, 1989, 13, 15-19
33. Ethanol-induced hepatic fibrosis in the rat: Role of the amount of dietary fat, S.W. French, K. Miyamoto, H. Tsukamoto, Alcoholism Clin Exp Res, 1986, 10, 135-195
34. Response of (n-3) and (n-6) fatty-acids in piglet brain, liver and plasma to increasing, but low, fish oil supplementation of formula, L.D. Arbuckle, F.M. Rioux, M.J. Mackinnon, N. Hrboticky, S.M. Innis, J Nutr, 1991, 121, 1536-1547
35. Retinoids affect collagen synthesis through inhibition of ascorbate-induced lipid peroxidation in cultured human dermal fibroblasts, J.C. Geesin, J.S. Gordon, R.A. Berg, Arch Biochem Biophys, 1990, 278, 250-355
36. d-a-Tocopherol inhibits collagen α(1) gene expression in cultured human fibroblasts. Modulation of constitutive gene expression by lipid peroxidation, K. Houghlum, D.A. Brenner, M. Chojkler, J Clin Invest, 1991, 87, 2230-2235
37. Nutrition and inflammatory events: Highly unsaturated fatty acids (ω-3 vs ω-6) in surgical injury, G.L. Blackburn, Proc Soc Exp Biol Med, 1992, 700, 183-188
38. Biochemistry and physiology of n-3 fatty acids, W.E. Lands, FASEB J, 1992, 6, 2530-2536
39. Reductions in serum thromboxane, prostacyclin and leukotriene B4 levels in swine fed a fish oil supplement to an atherogenic diet, D.N. Kim, J. Schmee, C.S. Lee, O. Solis, W.A. Thomas, Exp Mol Pathol, 1991, 55, 1-12