Specific and dose‐dependent enzyme induction by omeprazole in human beings

Hepatology

Volumn 20, Issue 5, 1994, Pages 1204-1212

  Rost, Karl Ludwig ^a   Brösicke, Herbert ^a   Heinemeyer, Gerhard ^b   Roots, Ivar ^c  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

6BETA HYDROXYHYDROCORTISONE; ANTICONVULSIVE AGENT; CAFFEINE; CAFFEINE DERIVATIVE; CARBAMAZEPINE; CYTOCHROME P450 ISOENZYME; GAMMA GLUTAMYLTRANSFERASE; MEPHENYTOIN; OMEPRAZOLE; PARAXANTHINE; PHENYTOIN; PRIMIDONE; SACCHARIC ACID;

ADULT; AGED; ARTICLE; BREATH ANALYSIS; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; HUMAN; HUMAN EXPERIMENT; LIVER METABOLISM; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ABSORPTION; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CAFFEINE; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; GLUTARATES; HALF-LIFE; HUMANS; HYDROCORTISONE; MALE; MEPHENYTOIN; METHYLATION; MIDDLE AGED; OMEPRAZOLE; OXIDOREDUCTASES;

EID: 0028051743     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.1840200516     Document Type: Article

References (40)

1. Omeprazole is an aryl hydrocarbon‐like inducer of human hepatic cytochrome P450
2. Omeprazole and the induction of human cytochrome P‐450: a response to concerns about potential adverse effects
3. 13C‐[N‐3‐methyl]‐caffeine breath test in poor and extensive metabolizers of S‐mephenytoin
4. Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase reactions
5. Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism
6. Polymorphic hydroxylation of S‐mephenytoin and omeprazole metabolism in Caucasian and Chinese subjects
7. Induction of cytochrome P4501A genes CYP1A by omeprazole in the human alimentary tract
8. Omeprazole: effects on oxidative drug metabolism
9. Omeprazole drug interaction studies
10. Effects of cimetidine on caffeine disposition in smokers and nonsmokers
11. Differential inhibition of individual human liver cytochromes P‐450 by cimetidine
12. Inducing effect of albendazole on rat liver drug‐metabolizing enzymes and metabolite pharmacokinetics
13. Inducing effect of oxfendazole on cytochrome P450IA2 in rabbit liver
14. d‐Glucaric acid excretion in critical care patients: comparison with 6β‐hydroxycortisol excretion and serum γ‐glutamyltranspeptidase activity and relation to multiple drug therapy
15. Evaluation of in vivo parameters of drug metabolizing enzyme activity in man after administration of clemastine, phenobarbital and placebo
16. Human cytochrome P‐450PA (P‐450 IA2), the phenacetin O‐deethylase, is primarily responsible for the hepatic 3‐demethylation of caffeine and N‐oxidation of carcinogenic arylamines
17. Evidence for the involvement of several cytochromes P‐450 in the first steps of caffeine metabolism by human liver microsomes
18. Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms
19. Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA‐expressed human CYP1A2 and CYP2E1
20. Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and saliva
21. The increase in urinary excretion of 6β‐hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction
22. Phenobarbital‐induced increase in 6β‐hydroxycortisol excretion: Clue to its significance in human urine
23. Measurement of urinary 6β‐hydroxycortisol excretion as an in vivo parameter in the clinical assessment of the microsomal enzyme‐inducing capacity of antipyrine, phenobarbitone and rifampicin
24. Quantitative determination by HPLC of urinary 6β‐hydroxycortisol, an indicator of enzyme induction by rifampicin and antiepileptic drugs
25. Plasma gamma glutamyl‐transpeptidase elevation in patients receiving enzyme inducing drugs
26. Assessment of plasma glutamyl transpeptidase activity and urinary d‐glucaric acid excretion as indices of enzyme induction
27. Serum gamma glutamyl transferase activities in epileptic patients receiving carbamazepine monotherapy
28. A urinary metabolite ratio that reflects systemic caffeine clearance
29. Determination of omeprazole and metabolites in plasma and urine by liquid chromatography
30. 2 breath test: dose response and route of N‐demethylation in smokers and nonsmokers
31. Assessment of the cytochrome P‐448‐dependent liver enzyme system by a caffeine breath test
32. Omeprazole treatment does not affect the metabolism of caffeine
33. Pharmacokinetics and bioavailability of omeprazole after single and repeated oral administration in healthy subjects
34. 14C]omeprazole in patients with liver cirrhosis
35. Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: transcriptional activation of the human CYP1A1 gene
36. Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin
37. Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP
38. Stimulatory effect of brussels sprouts and cabbage on human drug metabolism
39. Cytochrome P450 IA2 activity in man measured by caffeine metabolism: effect of smoking, broccoli and exercise
40. Enhanced phenacetin metabolism in human subjects fed charcoal‐broiled beef