Benzoselenazolinone Derivatives Designed To Be Glutathione Peroxidase Mimetics Feature Inhibition of Cyclooxygenase/5-Lipoxygenase Pathways and Anti-inflammatory Activity

Journal of Medicinal Chemistry

Volumn 37, Issue 18, 1994, Pages 2903-2911

  Galet, Vincent ^a,b,c,d   Bernier, Jean Luc ^a,b,c,d   Hénichart, Jean Piere ^a,b,c,d   Lesieur, Daniel ^a,b,c,d   Abadie, Claire ^a,b,c,d,e   Rochette, Luc ^a,b,c,d,e   Lindenbaum, Albert ^a,b,c,d   Chalas, Jacqueline ^a,b,c,d   de la Faverie, Jean François Renaud ^a,b,c,d   Pfeiffer, Bruno ^a,b,c,d   Renard, Piere ^a,b,c,d  

^a Institut de Chimie Pharmaceutique Albert Lespagnol   (France)

^b UNIVERSITÉ DE BOURGOGNE   (France)

^c HÔPITAL ANTOINE BÉCLÈRE   (France)

^d ADIR   (France)

^e Nancy Laboratoire de Physiologie   (France)

Author keywords

[No Author keywords available]

Indexed keywords

6 BENZOYLBENZOSELENAZOLINONE; ARACHIDONATE 5 LIPOXYGENASE; BIS[(2 AMINO 5 BENZOYL)PHENYL] DISELENIDE; CALCIMYCIN; EBSELEN; GLUTATHIONE PEROXIDASE; INDOMETACIN; PROSTAGLANDIN SYNTHASE; SELENAZOLE DERIVATIVE; SELENIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EDEMA; HUMAN; HUMAN CELL; INFLAMMATION; NONHUMAN; OXIDATIVE STRESS; RAT; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; AZOLES; CYCLOOXYGENASE INHIBITORS; GLUTATHIONE PEROXIDASE; HEMOLYSIS; HUMAN; IN VITRO; LIPID PEROXIDATION; LIPOXYGENASE INHIBITORS; MALE; ORGANOSELENIUM COMPOUNDS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0028049802     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00044a011     Document Type: Article

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