Vaninolol: A new selective β1-adrenoceptor antagonist derived from vanillin

Biochemical Pharmacology

Volumn 48, Issue 1, 1994, Pages 101-109

  Bin Nan, Wu ^a   Tsong Long, Hwang ^a   Ching Fong, Liao ^b   Ing Jun, Chen ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b ACADEMIA SINICA   (Taiwan)

Author keywords

inotropic and chronotropic effects; intrinsic sympathomimetic activity; membrane stabilizing activity; myocardial depressant effect; octanol water partition coefficient; radioligand binding study

Indexed keywords

ACEBUTOLOL; ATENOLOL; BETA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; DIHYDROALPRENOLOL; ISOPRENALINE; METOPROLOL; PHENYLEPHRINE; PROPRANOLOL; TOLAMOLOL; UNCLASSIFIED DRUG; URETHAN; VANILLIN DERIVATIVE; VANINOLOL;

ALPHA ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BETA ADRENERGIC STIMULATION; CARDIOVASCULAR EFFECT; CHRONOTROPISM; CONTROLLED STUDY; DRUG COMPETITION; DRUG SELECTIVITY; FEMALE; GUINEA PIG; HEART LEFT ATRIUM; HEART RIGHT ATRIUM; HEMODYNAMICS; INOTROPISM; INTRAVENOUS DRUG ADMINISTRATION; INTRINSIC SYMPATHOMIMETIC ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TRACHEA;

ANIMALS; BENZALDEHYDES; BLOOD PRESSURE; BUTANONES; FEMALE; GUINEA PIGS; HEART RATE; MALE; PROPANOLAMINES; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA-1; SYMPATHOMIMETICS;

EID: 0028049623     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(94)90229-1     Document Type: Article

References (30)

1. Beta-adrenergic blockers
2. Clinical perspective on celiprolol: cardioprotective potential
3. Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis: a controlled study
4. 1-adrenoceptor antagonist bisoprolol
5. Beta-adrenergic blocking agents: review and update
6. Negative inotropic effects and the hydrophobicity of beta-adrenergic blocking agents
7. Prediction of the non-specific cardiodepressant effects of β-adrenoceptor blocking agents in vitro and in vivo by means of the Hansch analysis
8. Relationship of nonspecific antiarrhythmic and negative inotropic activity with physicochemical parameters of propranolol analogues
9. Isoproterenol antagonism of cardioselective beta adrenergic receptor blocking agents: A comparative study of human and guinea-pig cardiac and bronchial beta adrenergic receptors
10. Xanthonolol: A calcium channel and beta-adrenoceptor blocker with vasodilating properties
11. Flavodilol: A new antihypertensive agent
12. The spirally cut tracheal strip preparation
13. The contribution of extraneuronal uptake to the trachea-blood vessel selectivity of β-adrenoceptor stimulants in vitro in guinea-pigs
14. β-adrenoceptor blocking agents as partial agonists in isolated heart muscle: Dissociation of stimulation and blockade
15. 2 values on guinea-pig trachea and atria
16. Some quantitative uses of drug antagonists
17. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
18. Hormone action at the membrane level VIII. Adrenergic receptors in rat heart and adipocytes and their modulation by thyroxine
19. 3H-(−)alprenolol binding sites, β-adrenergic receptors and adenylate cyclase
20. Measurement of hydrophobicity, surface activity, local anaesthesia, and myocardial conduction velocity as quantitative parameters of non-specific membrane affinity of nine β-adrenergic blocking agents
21. The assessment of β-adrenoceptor blocking potency and cardioselectivity in vitro and in vivo
22. THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
23. On the mechanism of the pressor response due to propranolol
24. On the pressor action of propranolol in the rat
25. Pressor action of beta blocking agents in rats
26. 2-adrenoceptor blockade and circulating adrenaline level for the pressor responses to β-adrenoceptor blocking drugs in rats
27. 3H-ICl 118,551 and blocking potency of ICl 118,551
28. Stimulant and depressant effects of β-adrenoceptor blocking agents on isolated heart muscle: a positive inotropic effect not mediated through adrenoceptors
29. Comparison of the apparent irreversible β-adrenoceptor antagonist Ro 03-7894 with propranolol in cardiac ventricular muscle by pharmacological and radioligand binding techniques
30. 3H]-dihydroalprenolol binding to rat cardiac membranes by various β-blocking agents