Humanization of murine monoclonal antibodies through variable domain resurfacing

Proceedings of the National Academy of Sciences of the United States of America

Volumn 91, Issue 3, 1994, Pages 969-973

  Roguska, Michael A ^a   Pedersen, Jan T ^b   Keddy, Christine A ^a   Henry, Andrew H ^b   Searle, Stephen J ^b   Lambert, John M ^a   Goldmacher, Victor S ^a   Blättler, Walter A ^a   Rees, Anthony R ^b   Guild, Braydon C ^a  

^a IMMUNOGEN INC   (United States)

^b UNIVERSITY OF BATH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; COMPLEMENTARY DNA; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBODY AFFINITY; ARTICLE; CELL SURFACE; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACRONICTA LEPORINA; ANIMALIA; MURINAE;

EID: 0028049374     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.91.3.969     Document Type: Article

References (42)

1. Köhler, G. & Milstein, C. (1975) Nature (London) 256, 495-497.
2. LoBuglio, A. F., Wheeler, R. H., Trang, J., Haynes, A., Rogers, K., Harvey, E. B., Sun, L., Ghrayeb, J. & Khazaeli, M. B. (1989) Proc. Natl. Acad. Sci. USA 86, 4220-4224.
3. Reichman, L., Clark, M., Waldmann, H. & Winter, G. (1988) Nature (London) 332, 323-327.
4. Kettleborough, C. A., Saldahha, J., Heath, V. J., Morrison, C. J. & Bendig, M. M. (1991) Protein Eng. 4, 773-783.
5. Foote, J. & Winter, G. (1992) J. Mol. Biol. 224, 487-499.
6. Morrison, S., Johnson, M. J., Hersenberg, S. A. & Oi, V. T. (1984) Proc. Natl. Acad. Sci. USA 81, 6851-6855.
7. Westhof, E., Altshuh, D., Moras, D., Bloomer, D., Modragon, A. C., Klug, A. & van Regenmortel, M. H. V. (1984) Nature (London) 311, 123-126.
8. Tainer, J. A., Getzoff, E. D., Alexander, H., Houghten, R. A., Olsen, A. J. & Lerner, R. A. (1984) Nature (London) 312, 127-133.
9. Thornton, J. M., Edwards, M. S., Taylor, W. R. & Barlow, D. J. (1986) EMBO J. 5, 409-413.
10. Novotny, J., Handschumacher, M., Haber, E., Bruccoleri, R. E., Carlson, W. B., Fanning, D. W., Smith, J. A. & Rose, G. D. (1986) Proc. Natl. Acad. Sci. USA 83, 226-230.
11. Padlan, E. (1991) Mol. Immunol. 28, 489-498.
12. Pedersen, J. T., Henry, A. H., Searle, S. J., Guild, B. C., Roguska, M. & Rees, A. R. (1994) J. Mol. Biol. 235, 959-973.
13. Griffin, J. D., Hercend, T., Beveridge, R. & Schlossman, S. F. (1983) J. Immunol. 130, 2947-2951.
14. Nitta, T., Yagata, H., Sato, K. & Okumura, K. (1989) J. Exp. Med. 170, 1757-1761.
15. Nadler, L. M., Anderson, K. C., Marti, G., Bates, M. P., Park, E., Daley, J. F. & Schlossman, S. F. (1983) J. Immunol. 131, 244-250.
16. Bernstein, F., Keutzler, P., Williams, G., Mayer, E., Brice, M., Rogers, K., Kennard, O., Schmanouchi, T. & Tasumi, M. (1977) J. Mol. Biol. 112, 535-542.
17. Jeffrey, P. (1989) Ph.D. thesis (University of Oxford, U.K.).
18. Kabat, E. A., Wu, T. T., Reid-Miller, M., Perry, H. M. & Gottesman, K. S. (1991) Sequences of Proteins of Immunological Interest (DHHS, Washington, DC), 5th Ed.
19. Pedersen, J. T., Searle, S. M. J., Henry, A. H. & Rees, A. R. (1992) Immunomethods 1, 126-136.
20. Kabsch, W. & Sander, C. (1983) Biopolymers 22, 2577-2637.
21. Bleasby, A. & Wooten, J. (1990) Protein Eng. 3, 153-159.
22. Martin, A. C. R., Cheetham, J. C. & Rees, A. R. (1989) Proc. Natl. Acad. Sci. USA 86, 9268-9272.
23. Martin, A. C. R., Cheetham, J. C. & Rees, A. R. (1991) Methods Enzymol. 203, 121-153.
24. Marquart, M., Deisenhofer, J. & Huber, R. (1980) J. Mol. Biol. 141, 369-391.
25. Herron, J., He, X., Mason, M., Voss, E. & Edmundsen, A. (1989) Proteins: Struct. Funct. Genet. 5, 271-280.
26. Sheriff, S., Silverton, E. W., Padlan, E. A., Cohen, G. H., Smith-Gill, S. J., Finzel, B. C. & Davies, D. R. (1987) Proc. Natl. Acad. Sci. USA 84, 8075-8079.
27. Chothia, C., Lesk, A. M., Tramontano, A., Levitt, M., Smith-Gill, S. J., Air, G., Sheriff, S., Padlan, E. A., Davies, D., Tulip, W. R., Colman, P. M., Spinelli, S., Alzari, P. M. & Poljak, R. J. (1989) Nature (London) 342, 877-883.
28. Bruccoleri, R. E. & Karplus, M. (1987) Biopolymers 26, 137-168.
29. Orlandi, R., Gussow, D. H., Jones, P. T. & Winter, G. (1989) Proc. Natl. Acad. Sci. USA 86, 3833-3837.
30. Daugherty, B. L., DeMartino, J. A., Law, M.-F., Kawka, D. W., Singer, I. I. & Mark, G. E. (1991) Nucleic Acids Res. 19, 2471-2476.
31. Kozak, M. (1989) J. Cell Biol. 108, 229-241.
32. Jones, P. T., Dear, P. H., Foote, J., Neuberger, M. S. & Winter, G. (1986) Nature (London) 321, 522-525.
33. Maeda, H., Matsushita, S., Eda, Y., Kimachi, K., Tokiyoshi, S. & Bendig, M. M. (1991) Hum. Antibodies Hybridomas 2, 124-134.
34. Lambert, J. M., Goldmacher, V. S., Collinson, A. R., Nadler, L. M. & Blättler, W. A. (1991) Cancer Res. 51, 6236-6242.
35. Klobeck, H. G., Bornkamm, G. W., Combriato, G., Mocikat, R., Pohlenz, H. D. & Zachau, H. G. (1985) Nucleic Acids Res. 13, 6515-6529.
36. Bird, J., Galili, N., Link, M., Stites, D. & Sklar, J. (1988) J. Exp. Med. 168, 229-245.
37. Silberstein, L. E., Liwin, S. & Carmack, C. E. (1989) J. Exp. Med. 169, 1631-1643.
38. Awdeh, Z. L., Williamson, A. R. & Askonas, B. A. (1970) Biochem. J. 116, 241-248.
39. Goldmacher, V. S., Lambert, J. M., Yau-Young, A., Anderson, J., Tinnel, N. L., Kornacki, M., Ritz, J. & Blättler, W. A. (1986) J. Immunol. 136, 320-325.
40. Hamilton, R. G., Roebber, M., Reimer, C. B. & Rodkey, L. S. (1987) Electrophoresis 8, 127-134.
41. Fasullo, F. J., Fritsche, H. A., Liu, F. J. & Hamilton, R. G. (1989) Clin. Chem. 35, 364-368.
42. Tracy, R. P., Currie, R. M., Kyle, R. A. & Young, D. S. (1982) Clin. Chem. 28, 900-907.