Dynamics of a Flexible Loop in Dihydrofolate Reductase from Escherichia coli and Its Implication for Catalysis

Biochemistry

Volumn 33, Issue 2, 1994, Pages 439-442

  Falzone, Christopher J ^a   Benkovic, Stephen J ^a   Wright, Peter E ^b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; DIHYDROFOLATE REDUCTASE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; ESCHERICHIA COLI; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

CATALYSIS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; FOLIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; METHOTREXATE; MOLECULAR STRUCTURE; NADP; PROTEIN CONFORMATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0028049327     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00168a007     Document Type: Article

References (26)

1. Adams, J., Johnson, K., Matthews, R., & Benkovic, S. J. (1989) Biochemistry 28, 6611–6618.
2. Adams, J. A., Fierke, C. A., & Benkovic, S. J. (1991) Biochemistry 30, 11046–11054.
3. Appleman, J. R., Howell, E. E., Kraut, J., & Blakley, R. L. (1990) J. Biol. Chem. 265, 5579–5584.
4. Benkovic, S. J., Fierke, C. A., & Naylor, A. M. (1988) Science (Washington, D.C.) 239, 1105–1110.
5. Bodenhausen, G., Kogler, H., & Ernst, R. R. (1984) J. Magn. Reson. 58, 370–388.
6. Bolin, J. T., Filman, D. J., Matthews, D. A., Hamlin, R. C., & Kraut, J. (1982) J. Biol. Chem. 257, 13650–13662.
7. Bothner-By, A. A., Stephens, R. L., Lee, J., Warren, C. D., & Jeanloz, R. W. (1984) J. Am. Chem. Soc. 106, 811–813.
8. Bystroff, C., & Kraut, J. (1991) Biochemistry 30, 2227–2239.
9. Bystroff, C., Oatley, S. J., & Kraut, J. (1990) Biochemistry 29, 3263–3277.
10. Cayley, P. J., Dunn, S. M. J., & King, R. W. (1981) Biochemistry 20, 874–879.
11. Davis, D. G. (1989) J. Magn. Reson. 81, 603–607.
12. Drobny, G., Pines, A., Sinton, S., Weitekamp, D. P., & Wemmer, D. (1979) Symp. Faraday Soc. 13, 49–55.
13. Falzone, C. J., Benkovic, S. J., & Wright, P. E. (1990) Biochemistry 29, 9667–9677.
14. Falzone, C. J., Wright, P. E., & Benkovic, S. J. (1991) Biochemistry 30, 2184–2191.
15. Farnum, M. F., Magde, D., Howell, E. E., Hirai, J. T., Warren, M. S., Grimsley, J. K., & Kraut, J. (1991) Biochemistry 30, 11567–11579.
16. Fierke, C. A., Johnson, K. A., & Benkovic, S. J. (1987) Biochemistry 26, 4085–4092.
17. Hershlag, D. (1988) Bioorg. Chem. 16, 62–96.
18. Jeener, J., Meier, B. H., Bachmann, P., & Ernst, R. R. (1979) J. Chem. Phys. 71, 4546–4553.
19. Kumar, A., Ernst, R. R., & Wüthrich, K. (1980) Biochem. Biophys. Res. Commun. 95, 1–6.
20. Li, L., Falzone, C. J., Wright, P. E., & Benkovic, S. J. (1992) Biochemistry 31, 7826–7833.
21. Marion, D., & Wüthrich, K. (1983) Biochem. Biophys. Res. Commun. 113, 967–974.
22. Murphy, D. J., & Benkovic, S. J. (1989) Biochemistry 28, 3025–3031.
23. Otting, G., Widmer, H., Wagner, G., & Wüthrich, K. (1986) J. Magn. Reson. 66, 187–193.
24. Sampson, N. S., & Knowles, J. R. (1992a) Biochemistry 31, 8482–8487.
25. Sampson, N. S., & Knowles, J. R. (1992b) Biochemistry 31, 8488–8494.
26. Sandström, J. (1982) Dynamic NMR Spectroscopy, Academic Press, New York.