Developmental switches in the immune system

Cell

Volumn 76, Issue 2, 1994, Pages 207-218

  Weissman, Irving L ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE RECEPTOR;

ADULT; CELL DEATH; DEVELOPMENTAL BIOLOGY; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; LYMPHOID ORGAN; MORPHOMETRICS; NEWBORN; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; REVIEW; STEM CELL; T LYMPHOCYTE; THYMUS;

EID: 0028049190     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90329-8     Document Type: Review

References (144)

1. Early events in T-cell maturation
2. H fusions
3. Ordered rearrangement of immunoglobulin heavy chain variable region segments
4. MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus
5. Cloning the chromosomal breakpoint of t(14;18) human lymphomas clustering around JH on chromosome 14 and near a transcriptional unit on 18
6. Isolation of a candidate human hematopoietic stem cell population
7. Binding of L-selectin to the vascular sialomucin CD34
8. Maturation of the immune response in germinal centers
9. Homing receptors and vascular addressins cell adhesion molecules that direct lymphocyte traffic
10. α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1
11. The foreign antigen binding site and T cell recognition region of class I histocompatibility antigens
12. Recombination between immunoglobulin variable region gene segments is enhanced by transcription
13. bcl-x a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
14. Development of the CD4 and CD8 lineage of T cells: instruction versus selection
15. MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1
16. Surface phenotype of Peyer's patch germinal center cells implications for the role of germinal centers in B cell differentiation
17. Another view of the selective model of thymocyte selection
18. A superantigen encoded in the open reading frame of the 3′ long terminal repeat of mouse mammary tumor virus
19. Relationship of germinal centers in lymphoid tissue to immunologic memory IV Transfer of B cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin
20. Normal B cell development and antibody deficiency diseases
21. The mechanism of action of cyclosporin A and FK 506
22. Thymocyte development in major histocompatibility complex-deficient mice evidence for stochastic commitment to the CD4 and CD8 lineages
23. Abnormal migration of T lymphocyte clones
24. Evidence for a stochastic mechanism on the differentiation of mature subsets of T lymphocytes
25. The human thymus microenvironment heterogeneity detected by monoclonal anti-epithelial cell antibodies
26. Genes encoding ligands for deletion of Vβ11 T cells cose-gregate with mammary tumor virus genomes
27. The immune response to a simple antigenic determinant
28. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site
29. The phenotype of thymocytes derived from a single clonogenic precursor
30. Functional heterogeneity is associated with the cell cycle status of murine hematpoietic stem cells
31. Studien über Regeneration der Gewebe
32. The role of lymphocytes in antibody formation II The influence of lymphocyte migration on the initiation of antibody formation in the isolated perfused spleen
33. Signal transduction events leading to T-cell lymphokine gene expression
34. A cell-surface molecule involved in organ-specific homing of lymphocytes
35. MHC-dependent antigen processing and peptide presentation ligands for T lymphocyte clonal activation
36. Mice lacking TdT mature animals with an immature lymphocyte repertoire
37. A human lymphocyte homing receptor the hermes antigen is related to cartilage proteoglycan core and link proteins
38. The granzyme A gene: a marker for cytolytic lymphocytes in vivo
39. T cell receptor β chain dimers on immature thymocytes from normal mice
40. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein
41. Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1
42. + precursors
43. − T cells bearing αβ T cell receptor
44. TCR-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages
45. Lymphoid tissue architecture experimental analysis of the origin and distribution of T cells and B cells
46. Quantitative analysis of molecules which distinguish functional compartments within germinal centers
47. Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors
48. Integrin molecules involved in lymphocyte homing to Peyer's patches
49. Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like α chain associated with either of two integrin β chains one of which is novel
50. Identification of a murine Peyer's patch-specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4α
51. Lymphocyte homing receptors
52. The junctional modifications of a T cell receptor γ chain are determined at the level of thymic precursors
53. A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells
54. Lymphocyte development from stem cells
55. Signals and signs for lymphocyte responses
56. Down-regulation of homing receptors after T cell activation
57. T cell tolerance by clonal elimination in the thymus
58. Induction of immunological unresponsiveness in vivo and in vitro by conventional and super-antigens in developing and mature T cells
59. A new surface antigen an intraepithelial lymphocytes in the intestine
60. Identification of a 107-kD glycoprotein that mediates adhesions between stromal cells and hematolymphoid cells
61. A single stem cell can recolonize an embryonic thymus producing phenotypically distinct T-cell populations
62. A critical role of λ5 protein in B cell development
63. Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes
64. Germinal center B cells antigen specificity and changes in heavy chain class expression
65. Memory B cells express a phenotype consistent with migratory competence after secondary but not short-term primary immunization
66. − intermediate
67. An endothelial ligand for L-selectin is a novel mucin-like molecule
68. Characteristics of thymus-homing bone marrow cells
69. Development of circadian periodicity in base and stress levels of corticosterone
70. + hemopoietic stem cells
71. Mitogen- and IL-4-regulated expression of germ-line lg γ2b transcripts evidence for directed heavy chain class switching
72. Subversion of the immune system by pathogens
73. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
74. A receptor-mediated model of viral leukemogenesis: hypothesis and experiments
75. AKR leukemogenesis identification and biological significance of thymic lymphoma receptors for AKR retroviruses
76. Antigens in immunity V The phagocytic reticulum of lymph node follicles
77. Evidence for a role of the integrin VLA-4 in lymphohemopoiesis
78. RAG-1-deficient mice have no mature B and T lymphocytes
79. Two types of murine helper T cell clone I Definition according to profiles of lymphokine activities and secreted proteins
80. Disappearance of the lymphoid system in bcl-2 homozygous mutant chimeric mice
81. Cloning and expression of cDNAs for the α subunit of the murine lymphocyte-Peyer's patch adhesion molecule
82. Heterogeneity of thymic epithelial cell (TEC) keratins immunohistochemical and biochemical evidence for a subset of highly differentiated TEC in the mouse
83. Negative selection of lymphocytes
84. Antigens in immunology XI Ultrastructural features of antigen capture in primary and secondary lymphoid follicles
85. Isolation of mouse CD44 cDNA structural features are distinct from the primate cDNA
86. Bcl-2 heterodimerizes in vivo with a conserved homology Bax that accelerates programed cell death
87. A subset of T cell receptors associated with L3T4 molecules mediates C6VL leukemia cell binding of its cognate retrovirus
88. Lymphocyte responses and cytokines
89. Programming B cell lymphocyte lifestyles
90. The structure function and molecular genetics of the γδ T cell receptor
91. In situ identification of idiotype-positive cells participating in the immune response to phosphorylcholine
92. Germinal center B cells lack homing receptors necessary for normal lymphocyte recirculation
93. A homing receptor-bearing cortical thymocyte subset implications for thymus cell migration and the nature of cortisone-resistant thymocytes
94. Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells
95. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage
96. Multifactorial regulation of the hypothalamic-pituitary-adrenal axis during development
97. Microanatomy of the thymus: its relationship to T cell differentiation
98. Expression of MHC antigens by mouse thymic dendritic cells
99. Mouse lymph node germinal centers contain a selected subset of T cells the helper phenotype
100. Expression of HLA antigens by human thymic epithelial cells
101. Monoclonal antibodies reactive with subsets of mouse and human thymic epithelial cells
102. An immunodominant murine lymphoma cell surface heterodimer marks thymic progenitor subsets
103. − thymocytes in short-term thymic stromal cell culture
104. Radiation leukemia virus-induced thymic lymphomas express a restricted repertoire of T cell receptor Vβ gene products
105. Bcl-2 inhibits multiple forms of apoptosis but not negative selection of thymocytes
106. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice
107. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
108. Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A
109. Human homologue of mouse lymph node homing receptor evolutionary conservation at tandem cell interaction domains
110. Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domains
111. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures
112. Clonal analysis of hematopoietic stem-cell differentiation in vivo
113. Resting and activated subsets of mouse multipotent hematopoietic stem cells
114. Mature T cells generated from single thymic clones are phenotypically and functionally heterogeneous
115. Purification and characterization of mouse hematopoietic stem cells
116. IO bone marrow cells repopulate the thymus
117. Two monoclonal antibodies identify thymic-repopulating cells in mouse bone marrow
118. Mouse hematopoietic stem cells
119. Traffic signals for lymphocyte recirculation and leukocyte emigration the multistep paradigm
120. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
121. Distinct binding specificities of integrins α4β7 (LPAM-1) α4β1 (VLA-4) and αIELβ7
122. Immunosuppressive and tolerogenic effects of whole-body, total lymphoid, and regional irradiation
123. Diversity development ligands and probable functions of γδ T cells
124. Heterogeneity of hematopoeitic stem cells
125. Distribution of H-2 microenvironments in the mouse thymus
126. + thymocytes: selection rather than instruction?
127. κ gene
128. Toward an understanding of the molecular mechanisms of physiological cell death
129. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
130. Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing
131. Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2
132. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis polycystic kidneys and hypopigmented hair
133. Positive selection of lymphocytes
134. Lymphocyte development
135. Human T-cell development in SCID-hu mice staphylococcal enterotoxins induce antigen specific clonal deletions proliferation and clonal anergy
136. Signal transduction by lymphocyte antigen receptors
137. Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas
138. Thymus cell maturation studies on the origin of cortisone-resistant thymic lymphocytes
139. In vitro cortisone sensitivity of in vivo cortisone-resistant thymocytes
140. Differentiation and migration of T lymphocytes
141. Normal and neoplastic maturation of T-lineage lymphocytes
142. An endogenous retrovirus mediating deletion of αβ T cells?
143. Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors
144. Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin