The Role of Platelet-derived Growth Factor Production by Tumor-associated Macrophages in Tumor Stroma Formation in Lung Cancer

Cancer Research

Volumn 54, Issue 20, 1994, Pages 5455-5463

  Vignaud, Jean Michel ^a,b   Marie, Béatrice ^a   Plénat, François ^a   Duprez, Adrien ^a   Martine, Yves ^b,c   Martinet, Nadine ^b,c   Klein, Nathalie ^b   Borlyrel, Jacques ^c   Pech, Michael ^d  

^a Département d'Anatomie Pathologique ^*  (United States)

^b Clinique Pneumologique Médico Chirurgicale ^*  (United States)

^c UNIVERSITÉ DE LORRAINE   (France)

^d F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

IDOXURIDINE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR;

ADULT; AGED; ARTICLE; CELL DIVISION; CONTROLLED STUDY; DNA REPLICATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; LUNG NON SMALL CELL CANCER; MALE; MESENCHYME CELL; PRIORITY JOURNAL; STROMA CELL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR CELL; TUMOR GROWTH;

CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; FEMALE; HUMANS; LUNG NEOPLASMS; MACROPHAGES; MALE; MIDDLE AGED; PLATELET-DERIVED GROWTH FACTOR; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; STROMAL CELLS;

EID: 0028046042     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Dvorak, H.F. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315: 1650-1659, 1986.
2. Robbins, S.L. Cotran, R.S. and Kumar, V. Pathologic basis of disease Ed. 3. Philadelphia: W.B. Saunders, 1984.
3. Varmus, H. and Weinberg, R.A. Genes and the biology of cancer. Scientific American Library, New York, 215 pp. 1993.
4. Weinberg, R.A. Tumor suppressor genes. Science (Washington DC), 254: 1138-1146, 1991.
5. Deuel, T.F. and Huang, J.S. Platelet-derived growth factor: structure, function, and roles in normal and transformed cells. J. Clin. Invest. 74: 669-676, 1984.
6. Ross, R. Raines, E.W. and Bowen-Pope, D.F. The biology of platelet-derived growth factor. Cell, 46: 155-169, 1986.
7. Heldin, C.H. and Westermark, B. Growth oncogenes. Cell, 37: 9-20, 1984.
8. Yarden, Y. Escobedo, J.A. Kuang, W.J. Yang-Feng, T.L. Daniel, T.O. Tremble, P.M. Chen, E.Y. Ando, M.E. Harkins, R.N. Franche, U. Fried, V.A. Ullrich, A. and Williams, L.T. Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature (Lond.), 323: 226-232, 1986.
9. Nistér, M. Hammacher, A. Mellstrom, K. Siegbahn, A. Ronnstrand, L. Westermark, B. and Heldin, C.H. A glioma-derived PDGF A chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets. Cell, 52: 791-799, 1988.
10. Hart, C.E. Forstrom, J.W. Kelly, J.D. Seifert, R.A. Smith, R.A. Ross, R. Murray, M.J. and Bowen-Pope, D.F. Two classes of PDGF receptor recognize different isoforms of PDGF. Science (Washington DC), 240: 1529-1531, 1988.
11. Gronwald, R.G.K. Grant, F.J. Haldeman, B.A. Hart, C.E. O'Hara, P.J. Hagen, F.S. Ross, R. Bowen-Pope, D.F. and Murray, M.J. Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class. Proc. Natl. Acad. Sci. USA, 85: 3435-3439, 1988.
12. Ross, R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature (Lond.), 362: 801-809, 1993.
13. Martinet, Y. Rom, W. Grotendorst, G.R. Martin, G.R. and Crystal, R.G. Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages of patients with idiopathic pulmonary fibrosis. N. Engl. J. Med. 317: 202-209, 1987.
14. Martinet, Y. and Crystal, R.G. Pathogenesis of tissue fibrosis: inflammatory cell modulation of mesenchymal cell accumulation. In: J.P. Revillard and N. Wierzbicki (eds.), Tissue Fibrosis: Immune Cells and Mediators, pp. 13-31. Suresnes, France: Fonction Franco-Allemande, 1987.
15. Gauldie, J. Jordana, M. and Cox, G. Cytokines and pulmonary fibrosis. Thorax, 48: 931-935, 1993.
16. Aaronson, S.A. Growth factors and cancer. Science (Washington DC), 254: 1146-1152, 1991.
17. Silverberg, E. Boring, C.C. and Squires, T.S. Cancer statistics. CA Cancer J. Clin. 40: 9-26, 1990.
18. World Health Organization. Histological typing of lung tumors. Geneva, Switzerland: WHO, 1981.
19. Mountain, C.F. A new international staging system for lung cancer. Chest, 89: 225S-233S, 1986.
20. Kissel, P. Duprez, A. Bessot, M. Schmitt, J. and Dollander, A. Autoradiography in vivo of human cancers. Nature (Lond.), 210: 274-276, 1966.
21. Gratzner, H.G. Monoclonal antibody to 5-Bromo and 5-iododeoxyuridine. A new reagent for detection of DNA replication. Science (Washington DC), 218: 474-475, 1982.
22. Duprez, A. Borrelly, J. Grosdidier, G. Hoffmann, M. and Boileau, S. Cell kinetics of human tumors in vivo: immuno-histochemical detection of 5-iododeoxyuridine incorporated into DNA of growing cells. CR Acad. Sci. Paris, 308: 313-319, 1989.
23. Herren, B. Weyer, K.A. Rouge, M. Lötscher, P. and Pech, M. Conservation in sequence and affinity of human and rodent PDGF ligands and receptors. Biochim. Biophys. Acta, 1173: 294-302, 1993.
24. Hart, C.E. Seifert, R.A. Ross, R. and Bowen-Pope, D.F. Synthesis, phosphorylation and degradation of multiple forms of the PDGF receptor studied using a monoclonal antibody. J. Biol. Chem. 262: 10780-10785, 1987.
25. Kelly, J.D. Haldeman, B.A. Grant, F.J. Murray, M.J. Seifert, R.A. Bowen-Pope, D.F. Cooper, J.A. and Kazhauskas, A. PDGF stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation. J. Biol. Chem. 266: 8987-8992, 1991.
26. Bowen-Pope, D.F. and Ross, R. Methods for studying the PDGF receptor. Methods Enzymol. 109: 69-100, 1985.
27. Vanderlaan, M. and Thomas, C.B. Characterization of monoclonal antibodies to bromodeoxyuridine. Cytometry, 6: 501-505, 1985.
28. Shi, S.R. Key, M.B. and Kalra, K.R. Antigen retrieval in formalin fixed, paraffin embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J. Histochem. Cytochem. 39: 741-748, 1991.
29. Pech, M. Durga Rao, C. Robbins, K.C. and Aaronson, S.A. Functional identification of regulatory elements within the promotor region of PDGF 2. Mol. Cell. Biol. 9: 396-405, 1989.
30. Betsholtz, C. Johansson, A. Heldin, C.H. Westermark, B. Lind, P. Urdea, M.S. Eddy, R. Show, T.B. Philpott, K. Mellor, A.L. Knott, T.J. and Scott, J. cDNA sequence and chromosomal location of human platelet-derived growth factor A-chain and its expression in tumor cell lines. Nature (Lond.), 320: 695-699, 1986.
31. Melton, D.A. Krieg, P.A. Rebagliati, M.R. Maniatis, T. Zinn, K. and Green, M.R. Efficient in vitro synthesis of biologically active RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 12: 7035-7056, 1984.
32. Cox, K.H. Deleon, D.V. Angerer, L.H. and Angerer, R.C. Detection of mRNAs in sea urchin embryo by in situ hybridization using asymmetric RNA probes. Dev. Biol. 101: 485-502, 1984.
33. Stjernsward, J. and Stanley, K. Lung cancer: a worldwide health problem. Lung Cancer, 4: 11-24, 1988.
34. Duprez, A. Guerret, S. Vignaud, J.M. Plénat, F. Hartmann, D. and Grimaud, J.A. Interstitial matrix of human carcinomas and sarcomas transplanted to the nude mouse: immunolocalization of some human and murine components. Cell. Mol. Biol. 83: 647-654, 1987.
35. Thurlbeck, W.M. Pathology of the lung. New York: Thieme, 1988.
36. Liotta, L.A. Rao, C.N. and Barsky, S.M. Tumor invasion and the extra-cellular matrix. Lab. Invest. 49: 636-649, 1983.
37. Normann, S.J. Macrophages infiltration and tumor progression. Cancer Metastasis Rev. 4: 277-291, 1985.
38. Sone, S. Role of alveolar macrophages in pulmonary neoplasia. Biochim. Biophys. Acta, 823: 227-245, 1986.
39. Martinet, Y. Bitterman, P.B. Mornex, J.F. Grotendorst, G.R. Martin, G.R. and Crystal, R.G. Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity. Nature (Lond.), 319: 158-160, 1986.
40. Shimokado, K. Raines, E.W. Madtes, D.K. Barrett, T.B. Benditt, E.P. and Ross, R. A significant part of macrophage-derived growth factor consists of at least two forms of PDGF. CeU, 43: 277-286, 1985.
41. DiCorleto, P.E. and Bowen-Pope, D.F. Cultured endothelial cells produce a platelet-derived growth factor-like protein. Proc. Natl. Acad. Sci. USA, 80: 1919-1923, 1983.
42. Walker, L.N. Bowen-Pope, D.F. Ross, R. and Reidy, M.A. Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury. Proc. Natl. Acad. Sci. USA, 83: 7311-7315, 1986.
43. Antoniades, H.N. Bravo, M.A. Avila, R.E. Galanopoulos, T. Neville-Golden, T. Maxwell, M. and Sehman, M. Platelet-derived growth factor in idiopathic pulmonary fibrosis. J. Clin. Invest, 86: 1055-1064, 1990.
44. Vignaud, J.M. Allam, M. Martinet, N. Pech, M. Plénat, F. and Martinet, Y. Presence of platelet-derived growth factor in normal and fibrotic lung is specifically associated with interstitial macrophages while both interstitial macrophages and alveolar epithelial cells express the c-sis proto-oncogene. Am. J. Respir. Cell. Mol. Biol. 5: 531-538, 1991.
45. Nagaoka, I. Trapnell, B.C. and Crystal, R.G. Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis. J. Clin. Invest. 85: 2023-2027, 1990.
46. Dalla Favera, R. Gelmann, E.P. Gallo, R.C. and Wong-Staal, F. A human one gene homologous to the transforming gene (v-sis) of simian sarcoma virus. Nature (Lond.), 292: 31-35, 1981.
47. Waterfield, M.D. Scrace, G.T. and Whittle, N. Platelet-derived growth factor is structurally related to the putative transforming protein p. 8sis of simian sarcoma virus. Nature (Lond.), 304: 35-39, 1983.
48. Heldin, C.H. and Westermark, B. Growth factors: mechanism of action and relation to oncogenes. Cell, 37: 9-20, 1984.
49. Pech, M. Gazit, A. Arnstein, P. and Aaronson, S.A. Generation of fibrosarcomas in vivo by a retrovirus that expresses the normal B chain of platelet-derived growth factor and mimics the alternative splice pattern of the v-sis oncogene. Proc. Natl. Acad. Sci. USA, 86: 2693-2697, 1989.
50. Antoniades, H.N. Galanopoulos, T. Neville-Golden, J. and O'Hara, C.J. Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products. Proc. Natl. Acad. Sci. USA, 89: 3942-3946, 1992.
51. Betsholtz, C. Berg, J. Bywater, M. Petterson, M. Johnsson, A. Heldin, C.H. Ohlsson, R. Knott, T.J. Scott, J. Bell, G.I. and Westermark, B. Expression of multiple growth factor in a human lung cancer cell line. Int. J. Cancer, 39: 502-507, 1987.
52. Sariban, E. Sitaras, N.M. Antoniades, H.N. Kufe, D.W. and Pantazis, P. Expression of platelet-derived growth factor (PDGF)-related transcripts and synthesis of biologically active PDGF-like proteins by human malignant epithelial cell lines. J. Clin. Invest. 82: 1157-1164, 1988.
53. Bravo, M. Vasquez, R. Rubio, H. Salazar, M. Pardo, A. and Selman, M. Production of platelet-derived growth factor by human lung cancer. Respir. Med. 85: 479-485, 1991.
54. Söderdahl, G. Betsholtz, C. Jahansson, A. Nilsson, K. and Bergh, J. Differential expression of platelet-derived growth factor and transforming growth factor genes in small- and non-small-cell human lung carcinoma lines. Int. J. Cancer, 41: 636-641, 1988.
55. Bergh, J. The expression of the platelet-derived and transforming growth factor genes in human non-small lung cancer cell lines is related to tumor stroma formation in nude mice tumors. Am. J. Pathol. 133: 434-439, 1988.
56. Forsberg, K. Valyi-Nagy, I. Heldin, C.H. Herlyn, M. and Westermark, B. Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB. Proc. Natl. Acad. Sci. USA, 90: 393-397, 1993.
57. Bottazzi, B. Polentarutti, N. Acero, R. Balsari, A. Boraschi, D. and Guezzi, P. Regulation of the macrophage content of neoplasms by chemoattractants. Science (Washington DC), 220: 210-212, 1982.
58. Israel, L. Samak, R. Edelstein, R. Amouroux, J. Battesti, J.P. and De Saint-Florent, G. In vivo non-specific macrophage chemotaxis in cancer patients and its correlation with extent of disease, regional lymph node status, and disease-free survival. Cancer Res. 42: 2489-2494, 1982.
59. Graves, D.T. Jiang, Y.L. Williamson, M.J. and Valente, A.J. Identification of monocyte chemotactic activity produced by malignant cells. Science (Washington DC), 245: 1490-1493, 1989.
60. Martinet, N. Beck, G. Bernard, V. Plénat, F. Vaillant, P. Schooneman, F. Vignaud, J.M. and Martinet, Y. Mechanism for the recruitment of macrophages to cancer site: in vivo concentration gradient of monocyte chemotactic activity. Cancer (Phila.), 70: 854-860, 1992.
61. Ross, R. The fibroblast and wound repair. Biol. Rev. 43: 51-96, 1968.
62. Pierce, G.F. Mustoe, T.A. Altrock, B.W. Deurel, T.F. and Thomason, A. Role of platelet-derived growth factor in wound healing. J. Cell. Biochem. 45: 319-326, 1991.