Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence

MGG Molecular & General Genetics

Volumn 242, Issue 3, 1994, Pages 358-362

  Swan, David G ^a   Rodríguez, Ana M ^a   Vilches, Carmen ^a   Méndez, Carmen ^a   Salas, José A ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

Author keywords

Codon usage; Gene fusion; Oleandomycin; Polyketides; Streptomyces

Indexed keywords

ERYTHROMYCIN; OLEANDOMYCIN; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CODON USAGE; GENE FUSION; GENE STRUCTURE; GENETIC CODE; NONHUMAN; PRIORITY JOURNAL; RESTRICTION MAPPING; SEQUENCE HOMOLOGY; STREPTOMYCES ANTIBIOTICUS;

AMINO ACID SEQUENCE; CLONING, MOLECULAR; GENES, BACTERIAL; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; OLEANDOMYCIN; RESTRICTION MAPPING; SEQUENCE ALIGNMENT; STREPTOMYCES ANTIBIOTICUS; SUPPORT, NON-U.S. GOV'T;

EID: 0028044628     PISSN: 00268925     EISSN: 16174623     Source Type: Journal    
DOI: 10.1007/BF00280426     Document Type: Article

References (9)

1. 6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme
2. An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea
3. Modular organization of genes required for complex polyketide biosynthesis
4. Molecular genetics of polyketides and its comparison to fatty acid biosynthesis
5. Pleiotropical morphological and antibiotic deficiencies result from mutations in a gene encoding a tRNA-like product in Streptomyces coelicolor A3(2)
6. TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative, Streptomyces mutants
7. Homology between Streptomyces genes coding for synthesis of different polyketides used to clone antibiotic biosynthetic genes
8. Streptomyces antibioticus contains at least three oleandomycin resistance determinants, one of which shows similarity with proteins of the ABC-transporter superfamily
9. Codon usage in the G+C-rich Streptomyces genome