Distribution of dominant T cell receptor β chains in human intestinal mucosa

Journal of Experimental Medicine

Volumn 180, Issue 4, 1994, Pages 1337-1344

  Gross, Gerald G ^a   Schwartz, Verna L ^a   Stevens, Christopher ^a   Ebert, Ellen C ^b   Blumberg, Richard S ^c   Balk, Steven P ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; HUMAN; HUMAN TISSUE; INTESTINE LYMPHATIC TISSUE; INTESTINE MUCOSA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECTUM; SIGMOID; SMALL INTESTINE; T LYMPHOCYTE; TISSUE DISTRIBUTION; TRANSVERSE COLON;

EID: 0028041565     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.180.4.1337     Document Type: Article

References (19)

1. Bucy, R.P., C.-L.H. Chen, and M.D. Cooper. 1989. Tissue localization and CD8 accessory molecule expression of Tγδ cells in humans. J. Immunol. 142:3045.
2. Brandtzaeg, P., V. Bosnes, T.S. Halstensen, H. Scott, L.M. Sollid, and K.N. Vaines. 1989. T lymphocytes in human gut epithelium preferentially express the α/β antigen receptor and are often CD45/UCHL1-positive. Scand. J. Immunol. 30:123.
3. + counterparts in coeliac disease. Immunology. 71:460.
4. + (T cell receptor α/β or γ/δ) and CD3-lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood. Eur. J. Immunol. 20:1097.
5. Trejdosiewicz, L.K., C.J. Smart, DJ. Oakes, P.D. Howdle, G. Malizia, D. Campana, and A.W. Boylston. 1989. Expression of T-cell receptors TcR1 (γ/δ) and TcR2 (α/β) in the human intestinal mucosa. Immunology. 68:7.
6. Deusch, K., F. Luling, K. Reich, M. Classen, H. Wagner, and K. Pfeffer. 1991. A major fraction of human intraepithelial lymphocytes simultaneously expresses the γ/δ T cell receptor, the CD8 accessory molecule and preferentially uses the Vδ1 gene segment. Eur. J. Immunol. 21:1053.
7. Balk, S.P., E.C. Ebert, R.L. Blumenthal, F.V. McDermott, K.W. Wucherpfennig, S.B. Landau, and R.S. Blumberg. 1991. Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes. Science (Wash. DC). 253:1411.
8. Van Kerckhove, C., G.J. Russell, K. Deusch, K. Reich, A.K. Bhan, H. DerSimonian, and M.B. Brenner. 1992. Oligoclonality of human intestinal intraepithelial T cells. J. Exp. Med. 175:57.
9. Blumberg, R.S., C.E. Yockey, E.C. Ebert, and S.P. Balk. 1993. Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones which utilize multiple Vβ T cell receptor genes. J. Immunol. 150:5144.
10. Taunk, J., A.I. Roberts, and E.C. Ebert. 1992. Spontaneous cytotoxicity of human intraepithelial lymphocytes against epithelial cell tumors. Gastroenterology. 102:69.
11. - α/β T cells demonstrates preferential use of several Vβ genes and an invariant TCR-α chain. J. Exp. Med. 178:1.
12. -) lymphocytes bearing T-cell receptor α and β chains in normal human skin. Proc. Natl. Acad. Sci. USA. 86:5059.
13. β expression in normal human skin. Proc. Natl. Acad. Sci. USA. 90:1267.
14. - T cells bearing T-cell receptor α and β chains in two normal men. Blood. 79:2965.
15. - subset. J. Exp. Med. 177:1763.
16. - T cells express oligoclonal TCRs, share junctional motifs across TCRVβ gene families and phenotypically resemble memory T cells. Proc. Natl. Acad. Sci. USA. 90:11787.
17. + cells with restricted T cell receptor δ gene junctional repertoire in the peripheral blood of healthy donors. J. Exp. Med. 178:121.
18. Delfau, M.-H., A.J. Hance, D. LeCossier, E. Vilmer, and B. Grandchamp. 1992. Restricted diversity of Vγ9-JP rearrangements in unstimulated human γ/δ T lymphocytes. Eur. J. Immunol. 22:2437.
19. Posnett, D.N., R. Sinha, S. Kabak, and C. Russo. 1994. Clonal populations of T cells in normal elderly humans: the T cell equivalent to "Benign Monoclonal Gammopathy". J. Exp. Med. 179:609.