MHC class II antigen processing: biology of invariant chain

Current Opinion in Immunology

Volumn 6, Issue 1, 1994, Pages 57-63

  Sant, Andrea J ^a   Miller, Jim ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHONDROITIN SULFATE; HERMES ANTIGEN; ISOPROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; CELLULAR DISTRIBUTION; ENDOCYTOSIS; ENDOSOME; IMMUNOMODULATION; INTRACELLULAR TRANSPORT; INVARIANT CHAIN; PROTEIN ASSEMBLY; PROTEIN PROCESSING; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION;

ANIMAL; ANTIGEN PRESENTATION; CHONDROITIN SULFATES; ENDOCYTOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMAN; PEPTIDES; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 0028038951     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/0952-7915(94)90034-5     Document Type: Article

References (64)

1. Chemistry and Functional Role of the Invariant Chain
2. Invariant Chain — a Regulator of Antigen Presentation
3. Formation of a Nine Subunit Complex by HLA Class II Glycoproteins and the Invariant Chain
4. Assembly and Transport Properties of Invariant Chain Trimers and HLA-DR-invariant Chain Complexes
5. Segregation of MHC Class II Molecules from MHC Class I Molecules in the Golgi Complex for Transport to Lysosomal Compartments
6. MHC Class II-Associated Invariant Chain Contains a Sorting Signal for Endosomal Compartments
7. Intracellular Transport of Class II MHC Molecules Directed by Invariant Chain
8. Invariant Chain Targets HLA Class II Molecules to Acidic Endosomes Containing Internalized Influenza Virus
9. Relationship Between Invariant Chain Expression and Major Histocompatibility Complex Class 11 Transport into Early and Late Endocytic Compartments
10. The Role of the la-Invariant Chain Complex in the Posttranslational Processing and Transport of Ia and Invariant Chain Glyroproteins
11. Invariant Chain Trimers Are Sequestered in the Rough Endoplasmic Reticulum in the Absence of Association of HLA Class II Antigens
12. Inhibition of Endosomal Proteolytic Activity by Leupeptin Blocks Surface Expression of MHC Class II Molecules and their Conversion to SDS Resistant αβ Heterodimers in Endosomes
13. Invariant Chain Retains MHC Class II Molecules in the Endocytic Pathway
14. Mouse B Lymphocyte Specific Endocytosis and Recycling of MHC Class II Molecules
15. Intracellular Distribution of the MHC Class II Molecules and the Associated Invariant Chain in Different Cell Lines
16. Cell Surface HLA-DR-Invariant Chain Complexes Are Targeted to Endosomes by Rapid Internalization
17. Enhanced Antigen Presentation in the Absence of the Invariant Chain Endosomal Localization Signal
18. Invariant Chain Promotes Egress of Poorly Expressed, Haplotype-Mismatched Class II Major Histocompatibility Complex AαAα Dimers from the Endoplas mic Reticulum/Cis-Golgi Compartment
19. Invariant Chain Influences Post-Translational Processing of HLA-DR Molecules
20. Invariant Chain Can Function as a Chaperone Protein for Class II Major Histocompatibility Complex Molecules
21. T and B Cell Receptors Discriminate Major Histocompatibility Complex Class II Conformations Influenced by the Invariant Chain
22. Invariant Chain Association with HLADR Molecules Inhibits Immunogenic Peptide Binding
23. Invariant Chain Distinguishes Between the Exogenous and Endogenous Antigen Presentation Pathways
24. Stable Surface Expression of Invariant Chain Prevents Peptide Presentation by HLA-DR
25. Sequence Analysis of Peptides Bound to MHC Class 11 Molecules
26. Peptides Presented to the immune System by the Marine Class II Major Histocompatibility Complex Molecule I-Ad
27. Predominant Naturally Processed Peptides Bound to HLA-DRI Arc Derived from MHC Related Molecules and Are Heterogeneous in Size
28. Characterization of Endogenous Peptides Bound to Purified HLA-DR Molecules and their Absence from Invariant Chain-Associated αβ Dimers
29. Specificity and Promiscuity Among Naturally Processed Peptides Bound to HLA-DR Alleles
30. HLA-DR Molecules from an Antigen Processing Mutant Cell Line Are Associated with Invariant Chain Peptides
31. Invariant Chain Peptides in Most HLA-DR Molecules of an Antigen Processing Mutant
32. Three-Dimensional Structure of the Human Class II Histocompatibility Antigen HLA-DRI
33. Capacity of Intact Proteins to Bind to MHC Class II Molecules
34. Acidification and Disulfide Reduction Can Be Sufficient to Allow Intact Proteins to Bind Class II MHC
35. Proteolysis of the Class II-Associated Invariant Chain Generates a Peptide Binding Site in Intracellular HLA-DR Molecules
36. Time Course of Intracellular Associations, Processing, and Cleavages of Ii Forms and Class II MHC Molecules
37. Intracellular Transport and Localization of Major Histocompatibility Complex Class II Molecules and Associated Invariant Chain
38. Endosomal Aspartic Proteinases are Required for Invariant Chain Processing
39. Energy Transfer Between Two Peptides Bound to One MHC Class II Molecule
40. Free Ligand-Induced Dissociation of MHC-Antigen Complexes
41. Antigen Presentation to HLA Class II-Restricted Measles Virus-Specific T Cell Clones Can Occur in the Ab sence of the Invariant Chain
42. Invariant Chain Influences the Im munological Recognition of MHC Class II Molecules
43. Antigen Presentation of Hen Egg Lysozyme but not Ribonuclease A is Augmented by the MHC Class II Associated Invariant Chain
44. Antigen Presentation Enhanced by the Alternatively Spliced Invariant Chain Gene Product p4l
45. Mice Lacking the MHC Class II-Associated Invariant Chain
46. Cloning of the Gene Encoding Peptide-Binding Protein 74 Shows that it is a Member of the Heat Shock Protein 70 Family
47. Defective Processing and Presentation of Exogenous Antigens in Mutants with Normal HLA Class II Genes
48. MHC Class II Deletion Mutant Expresses Normal Levels of Transgene Encoded Class II Molecules that have Abnormal Conformation and Impaired Antigen Presentation Ability
49. The Antigen Processing Mutant T2 Suggests a Role for MHC-Linked Genes in Class II Antigen Presentation
50. Formation of Complexes Between Self-Peptides and MHC Class II Molecules in Cells Defective for Presentation of Exogenous Protein Antigens
51. MHC Class II-Restricted Presentation of an Internally Synthesized Antigen Displays Cell Type Variability and Segregates from the Exogenous Class II and Endogenous Class I Antigen Presentation Pathways
52. A Mutant Antigen Presenting Cell Defective in Antigen Presentation Expresses Class II MHC Molecules with an Altered Conformation
53. The Chondroitin Sulfate form of Invariant Chain Can Enhance Stimulation of T Cell Responses Through Interaction with CD44
54. Invariant Chain is the Core Protein of the Ia-Associated Chondroitin Sulfate Proteoglycan
55. Biosynthetic Relationships of the Chondroitin Sulfate Proteoglycan with la and Invariant Chain Glycoproteins
56. IL-5 Induces a Pgp-1 (CD44) Bright B Cell Subpopulation that is Highly Enriched in Proliferative and Ig Secretory Activity and Binds to Hyaluronate
57. hi Population that Binds Specifically to Hyaluronate
58. Molecular Isoforms of Murine CD44 and Evidence that the Membrane Proximal Domain Is Not Critical for Hyaluronate Recognition
59. + T Cell Selection in Mice Lacking Invariant Chain
60. HLA-DR Associates with Specific Stress Proteins and is Retained in the Endoplasmic Reticulum in Invariant Chain Negative Cells
61. + Tumor Cells
62. Class II MHC Molecules of Murine Dendritic Cells: Synthesis, Sialylation of Invariant Chain, and Antigen Processing Capacity Are Down Regulated upon Culture
63. A Role of la-Associated Invariant Chains in Antigen Processing and Presentation
64. Correlation Between Invariant Chain Expression Level and Capability to Present Antigen to MHC Class II Restricted T Cells