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Bioorganic and Medicinal Chemistry Letters
Volumn 4, Issue 19, 1994, Pages 2307-2312
Total synthesis of novel conduritol related compounds capable of modulating insulin release.
Author keywords

[No Author keywords available]
Indexed keywords

ANTIDIABETIC AGENT; CONDURITOL B; CONDURITOL C; CONDURITOL E; CONDURITOL F; POLYOL; UNCLASSIFIED DRUG;
EID: 0028037707     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(94)85030-5     Document Type: Article
Times cited : (42)
References (26)
  • 6
    • 84908845511 scopus 로고    scopus 로고
    • European Patent EP-474-358-A to DAI-Nippon Sugar Co, 1992; Derwent 92-081887/11.
  • 7
    • 85064401100 scopus 로고
    • In the general context of cyclitols and insulin action, derivatives of chiro-inositol derived from the GPI anchor molecule have been shown to exert weak insulin like activity, and these compounds may represent mediators of insulin action. See for example
    • (1992) Synlett , pp. 997
    • Ley1    Yeung2
  • 19
    • 84908845510 scopus 로고    scopus 로고
    • ICI (Zeneca) France, 1 Avenue Newton, 92140, Clamart; cis - 1,2-dihydrocatechol Cat No 31064.
  • 24
    • 84908845509 scopus 로고    scopus 로고
    • 15 Routinely 150 islets were obtained from each rat. Following isolation, islets were incubated at 37°C in Kreb's Ringer bicarbonate buffer at pH7.4, containing 0.5% bovine serum albumin and either 2.8 or 16.7mM glucose. These concentrations were chosen to achieve basal (2.8mM) or maximal (16.7mM) stimulation of insulin secretion from the islets. After incubation for 4h two 50μl aliquots from each incubate were sampled and used for measurement of insulin (Pasedeph kit, pharmacia, France). Data are presented as the percentage increase or decrease in insulin secretion compared to the mean secretion obtained at each glucose concentration, in the absence of drug. Under these conditions, the mean basal and maximally stimulated rates of insulin secretion were 14.5 +/− 2.6 (n=8) and 27.5 +/− [[Truncated]]
  • 26
    • 84908845508 scopus 로고    scopus 로고
    • 13C NMR, mass spectral, and elemental analysis data, in agreement with their assigned structures.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.