Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families

Nature Genetics

Volumn 8, Issue 4, 1994, Pages 399-404

  Friedman, Lori S ^a   Ostermeyer, Elizabeth A ^a   Szabo, Csilla I ^a   Dowd, Patrick ^a   Lynch, Eric D ^a   Rowell, Sarah E ^a   King, Mary Claire ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYSTEINE; RNA;

ARTICLE; BREAST CANCER; CANCER RISK; CHROMOSOME 17Q; DNA POLYMORPHISM; FEMALE; FRAMESHIFT MUTATION; GENE MUTATION; GENETIC LINKAGE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; NONSENSE MUTATION; NUCLEIC ACID BASE SUBSTITUTION; OVARY CANCER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

BASE SEQUENCE; BRCA1 PROTEIN; BREAST NEOPLASMS; DNA, COMPLEMENTARY; FEMALE; GERM-LINE MUTATION; HUMAN; MALE; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; PEDIGREE; POLYMORPHISM (GENETICS); SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION FACTORS;

EID: 0028034348     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1294-399     Document Type: Article

References (8)

1. Miki, Y. et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66-71 (1994).
2. Hall, J.M. et al. Linkage of early-onset familial breast cancer to chromosome 17q21. Science 250, 1684-1689 (1990).
3. Albertsen, H.M. et al. A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21. Nature Genet. 7, 472-479 (1994).
4. Sharp, P.A. Split genes and RNA splicing. Cell 77, 805-815. (1994).
5. Friedman, L.S. et al. The search for BRCA1 and the cloning of 22 genes from chromosome 17q21. Cancer Res. (in the press).
6. American Society of Human Genetics. Statement on genetic testing for breast and ovarian cancer. Am. J. hum. Genet. 55, 860 (1994).
7. Rowell, S., Newman, B., Boyd, J. & King, M-C. Inherited predisposition to breast and ovarian cancer. Am. J. hum. Genet. 55, 861-865 (1994).
8. Arena, J.F. et al. Inherited breast cancer: Confirmation of linkage to BRCA2, possible linkage to the estrogen receptor, and the clinical implications of genetic complexity. J. Am. med. Assoc. (in the press).