Positive selection of lymphocytes

Cell

Volumn 76, Issue 2, 1994, Pages 219-228

  von Boehmer, Harald ^a,b  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN RECEPTOR; T LYMPHOCYTE RECEPTOR;

B LYMPHOCYTE; GENETIC SELECTION; GERMINAL CENTER; HUMAN; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0028032155     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90330-1     Document Type: Review

References (89)

1. CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome
2. MHC class II-positive epithelium and mesenchyme cells are both required for T cell development in the thymus
3. lck
4. Molecular and biological characterization of a murine ligand for CD40
5. The CD40 ligand gp39 is defective in activated T cells from patients with X-linked hyper-IgM syndrome
6. + T cells in the thymus
7. Activation events during thymic selection
8. Positive selection of the T cell repertoire where and when does it occur?
9. Maturation of the immune response in germinal centers
10. Alteration of negative selection in T cell receptor αβ transgenic mice
11. Inefficient positive selection of T cells directed by haematopoietic cells
12. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens
13. Development of the CD4 and CD8 lineage of T cells instruction versus selection
14. Exclusion and inclusion of α and β T cell receptor alleles
15. Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression
16. T cell receptor genes a series of class I major histocompatibility-complex-restricted cytotoxic T lymphocyte clones specific for a plasmodium berghei monopeptide implications for T cell allelic exclusion and antigen-specific repertoire
17. Another view of the selective model of thymocyte selection
18. Human pre-B and B cell membrane μ chains are noncovalently associated with a disulfide-linked complex containing a product of the B29 gene
19. Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression
20. Mice lacking MHC class II molecules
21. Evidence on a stochastic mechanism in the differentiation of mature subsets of T lymphocytes
22. CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM
23. The kinetics of mature T cell development in the thymus
24. H gene family expression in immunoglobulin-transgenic mice: evidence for selection of antibody repertoires
25. Cell surface expression of the T cell receptor β chain on pre-T cells
26. A role for a pre-T-cell receptor in T-cell development
27. T cell receptor β chain dimers on immature thymocytes from normal mice
28. T cell receptor β chain homodimers on the surface of immature but not mature α γ and δ chain deficient T cell lines
29. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein
30. B cell development regulated by gene rearrangement arrest of maturation by membrane-bound Dμ protein and selection of Dμ element reading frames
31. + T cells induced by MHC binding peptides in fetal thymic organ culture
32. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice
33. Intraclonal generation of antibody mutants in germinal centers
34. Mutations in the major histocompatibility complex class I antigen-presenting groove affect both negative and positive selection of T cells
35. Towards a network theory of the immune system
36. + T cell in transgenic mice expressing a class II MHC-restricted antigen receptor
37. Surface expression of the β T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells
38. Normal B lymphocyte development but impaired T cell maturation in CD45-exon 6 protein tyrosine phosphatase-deficient mice
39. + thymocytes
40. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
41. A B cell-deficient mouse by targeted disruption of the memebrane exon of the immunoglobulin μ chain gene
42. A critical role of λ5 protein in B cell development
43. Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM
44. How important is the direct recognition of polymorphic MHC residues by TCR in the generation of the T-cell repertoire
45. preB 1 in the λ-5 locus of the mouse which appears to be selectively expressed in pre-B lymphocytes
46. Regulation of thymocyte development through CD3 I Timepoint of ligation of CD3ε determines clonal deletion or induction of developmental program
47. lck in thymopoiesis
48. Mechanism of antigen-driven selection in germinal centres
49. T cell development in mice that lost the ζ chain of the T cell antigen receptor complex
50. Surface IgM mediated regulation of RAG gene expression in Eμ-N-myc B cell lines
51. Rearrangement and diversity of T cell receptor β chain genes in thymocytes a critical role for the β chain in development
52. lck
53. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
54. Role of self-peptides in positively selecting the T-cell repertoire
55. CD40 and its ligand an essential ligand-receptor pair for thymus-dependent B-cell activation
56. Negative selection of lymphocytes
57. Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities
58. Frequent expression of two TCR α chains in human αβ lymphocytes creates dual receptor cells
59. Positive selection of lymphocytes on fibroblasts
60. 2 tetramers in pre-B cells by the 18 Kd ω-immunoglobulin light chain
61. + cells but markedly decreased helper cell activity in mice lacking CD4
62. Developmental regulation of T-cell receptor gene expression
63. The B-cell antigen receptor complex
64. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage
65. Peripheral selection of the T cell repertoire
66. Generation and regeneration of cells of the B-lymphocytes lineage
67. 5, a new light-chain-related locus selectively expressed in pre-B lymphocytes
68. Maintenance of B cell memory by long-lived cells generated from proliferating precursors
69. The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens
70. Positive and negative selection of an antigen receptor on T cells in transgenic mice
71. Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding
72. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes
73. Ontogeny of the T-cell antigen receptor within the thymus
74. + thymocytes in suspension culture by extrathymic antigen-presenting cells
75. + thymocytes
76. Thymic major histocompatibility complex antigens and the specificity of the αβ T cell receptor determine the CD4/CD8 phenotype of T cells
77. Receptor editing in self-reactive bone marrow B cells
78. Somatic generation of antibody diversitiy
79. B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40
80. Thymocyte expression of RAG-1 and RAG-2 termination by T cell receptor cross-linking
81. In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes
82. The selection of the αβ heterodimeric T cell receptor for antigen
83. Developmental biology of T cells in T cell receptor transgenic mice
84. The life span of naive α/β T cells in secondary lymphoid organs
85. CD8 is needed for development of cytotoxic T cells but not helper T cells
86. Signal transduction by lymphocyte antigen receptors
87. Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen
88. H gene segments
89. + cytolytic T cells