Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis

Circulation

Volumn 90, Issue 3, 1994, Pages 1410-1422

  Weinberg, Ellen O ^a   Schoen, Frederick J ^b   George, Dorinda ^a   Kagaya, Yutaka ^a   Douglas, Pamela S ^a   Litwin, Sheldon E ^a   Schunkert, Heribert ^a   Benedict, Claude R ^c   Lorell, Beverly H ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

angiotensin; enzymes; fosinopril; hypertrophy

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CREATINE PHOSPHATE; DIPEPTIDYL CARBOXYPEPTIDASE; FOSINOPRIL; HYDROXYPROLINE; NORADRENALIN; RENIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA STENOSIS; ARTICLE; ASCENDING AORTA; CONTROLLED STUDY; ENZYME INHIBITION; HEART FAILURE; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CONTRACTILE FORCE; HEART RIGHT VENTRICLE HYPERTROPHY; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE OVERLOAD; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RAT; SURVIVAL RATE;

EID: 0028030372     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.90.3.1410     Document Type: Article

References (71)

1. The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Study Group. N Engl J Med. 1987;316:1429-1435.
2. The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med. 1992;327: 685-691.
3. Swedberg K, Held P, Kjekshus J, Rasmussen K, Ryden L, Wedel H, on behalf of the CONSENSUS II Study Group. Effects of the early administration of enalapril on mortality in patients with acute myocardial infarction: results of the Cooperative New Scandinavian Enalapril Survival Study II (CONSENSUS II). N Engl J Med. 1992;327:678-684.
4. Pfeffer JM, Pfeffer MA, Braunwald E. Influence of chronic captopril therapy on the infarcted left ventricle of the rat. Circ Res. 1985;57:84-95.
5. Pfeffer MA, Pfeffer JM, Steinberg C, Finn P. Survival after an experimental myocardial infarction: beneficial effects of long-term therapy with captopril. Circulation. 1985;72:406-412.
6. Sweet CS, Emmert SE, Stabilito II, Ribeiro LGT. Increased survival in rats with congestive heart failure treated with enalapril. J Cardiovasc Pharmacol. 1987;10:636-642.
7. Sweet CS, Ludden CT, Stabilito II, Emmert SE, Heyse JF. Beneficial effects of milrinone and enalapril on long-term survival of rats with healed myocardial infarction. Eur J Pharmacol. 1988;147: 29-37.
8. Richer C, Mulder P, Fornes P, Domergue V, Heudes D, Giudicelli J-F. Long-term treatment with trandolapril opposes cardiac remodeling and prolongs survival after myocardial infarction in rats. J Cardiovasc Pharmacol. 1992;20:147-156.
9. Riva E, Kurosaki M, Latini R. Effect of lisinopril and isosorbide-5-mononitrate on hemodynamics and mortality in rats with permanent coronary artery occlusion. J Cardiovasc Pharmacol. 1992; 20:490-495.
10. Haleen SJ, Weishaar RE, Overhiser RW, Bousley RF, Keiser JA, Rapundalo SR, Taylor DG. Effects of quinapril, a new angiotensin converting enzyme inhibitor, on left ventricular failure and survival in the cardiomyopathic hamster: hemodynamic, morphological, and biochemical correlates. Circ Res. 1991;68:1302-1312.
11. Nakashima Y, Fouad FM, Tarazi RC. Regression of left ventricular hypertrophy from systemic hypertension by enalapril. Am J Cardiol. 1984;53:1044-1049.
12. Dahlof B, Pennert K, Hansson L. Regression of left ventricular hypertrophy: a meta-analysis. Clin Exp Hypertens. 1992;A14: 173-180.
13. Sen S, Tarazi RC, Bumpus FM. Reversal of cardiac hypertrophy in renal hypertensive rats: medical vs. surgical therapy. Am J Physiol. 1981;240:H408-H412.
14. Kromer EP, Riegger GAJ. Effects of long-term angiotensin converting enzyme inhibition of myocardial hypertrophy in experimental aortic stenosis in the rat. Am J Cardiol. 1988;62:161-163.
15. Kromer EP, Elsner D, Riegger GAJ. Role of neurohumoral systems for pressure induced left ventricular hypertrophy in experimental supravalvular aortic stenosis in rats. Am J Hypertens. 1991; 4:521-524.
16. Dzau VJ. Autocrine and paracrine mechanisms in the pathophysiology of heart failure. Am J Cardiol. 1992;70:4C-11C.
17. Hirsch AT, Talsness CE, Schunkert H, Paul M, Dzau VJ. Tissue-specific activation of cardiac angiotensin converting enzyme in experimental heart failure. Circ Res. 1991;69:475-482.
18. Ruzicka M, Yuan B, Harmsen E, Leenen FHH. The reninangiotensin system and volume overload-induced cardiac hypertrophy in rats: effects of angiotensin converting enzyme inhibitor versus angiotensin II receptor blocker. Circulation. 1993;87: 921-930.
19. Baker KM, Chemin MI, Wixson SK, Aceto JF. Renin-angiotensin system involvement in pressure-overload cardiac hypertrophy in rats. Am J Physiol. 1990;259:H324-H332.
20. Lindpaintner K, Ganten D. The cardiac renin-angiotensin system: an appraisal of present experimental and clinical evidence. Circ Res. 1991;68:905-921.
21. Linz W, Schoelkens BA, Ganten D. Converting enzyme inhibitor specifically prevents development and induces the regression of cardiac hypertrophy in rats. Clin Exp Hypertens. 1989;11: 1325-1350.
22. Feldman A, Weinberg EO, Ray P, Lorell BH. Selective changes in gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding. Circ Res. 1993;73:184-192.
23. Schunkert H, Dzau VJ, Tang SS, Hirsch AT, Apstein CS, Lorell BH. Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy: effects on coronary resistance, contractility, and relaxation. J Clin Invest. 1990;86:1913-1920.
24. Schunkert H, Jackson B, Tang SS, Schoen FJ, Smits JFM, Apstein CS, Lorell BH. Distribution and functional significance of cardiac ACE in hypertrophied rat hearts. Circulation. 1993;87:1328-1339.
25. Cox DR, Oakes D. Analysis of Survival Data. London, UK: Chapman and Hall; 1984.
26. Litwin SE, Katz SE, Morgan JP, Douglas PS. Serial echocardiographic assessment of left ventricular geometry and function after large myocardial infarction in the rat. Circulation. 1994;89:345-354.
27. Anversa P, Loud AV, LeVicky V, Guideri G. Left ventricular failure induced by myocardial infarction: tissue morphometry. Am J Physiol. 1985;248(Heart Circ Physiol 17):H883-H889.
28. Ca, and pH: studies in isolated beating rabbit hearts and myocytes loaded with the indicator Indo-1. J Physiol (Lond). In press.
29. Hussain MN, Benedict AR. Radioenzymatic microassay for simultaneous estimations of dopamine, norepinephrine, and epinephrine in plasma, urine and tissues. Clin Chem. 1985;31: 1861-1864.
30. Sealy J, Laragh JH. How to do plasma renin assay. In: Laragh JH, ed. Topics in Hypertension. New York, NY: Yorke Medical Books; 1980:244-256.
31. Friedland J, Silverstein E. A sensitive fluorimetric assay for serum angiotensin-converting enzyme. Am J Clin Pathol. 1976;88: 416-423.
32. Adams H. Adenosine 5′-triphosphate determination with phosphoglycerate kinase. In: Bergmeyer HV, ed. Methods of Enzymatic Analysis. New York, NY: Academic Press, Inc; 1963:539-543.
33. Bergman I, Loxley R. Lung tissue hydrolysates: studies of the optimum conditions for the spectrophotometric determination of hydroxyproline. Analyst. 1969;94:575-584.
34. Lerman RH, Apstein CS, Kagan HM, Osmers EL, Chichester CO, Vogel WM, Connelly CM, Steffee WP. Myocardial healing and repair after experimental infarction in the rabbit. Circ Res. 1983; 53:378-388.
35. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193: 265-275.
36. Konstam MA, Rousseau MF, Kronenberg MW, Udelson JE, Melin J, Stewart D, Dolan N, Edens TR, Ahn S, Kinan D, Howe DM, Kilcoyne L, Metherall J, Benedict C, Yusuf S, Pouleur H, for the SOLVD Investigators. Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dysfunction in patients with heart failure. Circulation. 1992;86:431-438.
37. Grossman W, Carabello BA, Gunther S, Fifer MA. Ventricular wall stress and the development of cardiac hypertrophy and failure. In: Alpert NR, ed. Perspectives in Cardiovascular Research. New York, NY: Raven Press; 1983:1-18.
38. Krayenbuehl HP, Hess OM, Ritter M, Schneider J, Monrad ES, Grimm J. Influence of pressure and volume overload on diastolic compliance. In: Grossman W, Lorell BH, eds. Diastolic Relaxation of the Heart. Boston, Mass: Martinus-Nijhoff; 1988:143-150.
39. Weber KT, Brilla CG. Pathological hypertrophy and cardiac interstitium: fibrosis and renin-angiotensin-aldosterone system. Circulation. 1991;83:1849-1865.
40. Mukherjee D, Sen S. Collagen phenotype during development and regression of myocardial hypertrophy in spontaneously hypertensive rats. Circ Res. 1990;67:1474-1480.
41. Morgan HE, Baker KM. Cardiac hypertrophy: mechanical, neural, and endocrine dependence. Circulation. 1991;83:13-25.
42. Chien KR, Knowlton KU, Zhu H, Chien S. Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiological response. FASEB J. 1991;5:3037-3046.
43. Baker KM, Aceto JF. Angiotensin II stimulation of protein synthesis and cell growth in chick heart cells. Am J Physiol. 1990;259: H610-H618.
44. Komuro I, Katoh Y, Shibasaki Y, Yamaguchi H, Yazaki Y. Angiotensin II induces hypertrophy and oncogene expression in cultured rat heart myocytes. Circulation. 1989;80(suppl II):II-450. Abstract.
45. 2+ mobilization and protein kinase C activation. J Biol Chem. 1989;264:526-530.
46. Sadishima J, Xu Y, Slayter HS, Izumo S. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. 1993;75:977-984.
47. 2 receptor subtypes: an analysis of hypertrophied rat hearts. Am J Physiol. In press.
48. Meggs LG, Coupet J, Huang H, Cheng W, Li P, Capasso JM, Homey CJ, Anversa P. Regulation of angiotensin II receptors on ventricular myocytes after myocardial infarction in rats. Circ Res. 1993;72:1149-1162.
49. Iwai N, Inagami T. Identification of two subtypes in the rat type I angiotensin II receptor. FEBS Lett. 1992;298:257-260.
50. Xiang J, Linz W, Becker H, Ganten D, Lang RE, Schoelkens B, Unger T. Effects of converting enzyme inhibitors: ramipril and enalapril on peptide action and sympathetic neurotransmission in the isolated rat heart. Eur J Pharmacol. 1985;113:215-223.
51. Wiemer G, Schoelkens BA, Becker RHA, Busse R. Ramiprilat enhances endothelial autacoid formation by inhibiting breakdown of endothelium-derived bradykinin. Hypertension. 1991;18: 558-563.
52. Lorell BH, Grossman W. Cardiac hypertrophy: the consequences for diastole. J Am Coll Cardiol. 1987;9:1189-1193.
53. Isoyama S, Ito N, Koroha M, Takashima T. Complete reversibility of physiologic coronary flow abnormalities in hypertrophied hearts produced by pressure-overload in the rat. J Clin invest. 1989;84: 288-294.
54. Eberli FR, Apstein CS, Ngoy S, Lorell BH. Exacerbation of left ventricular ischemic diastolic dysfunction by pressure overload hypertrophy: modification by specific inhibition of cardiac angiotensin converting enzyme. Circ Res. 1992;70:931-943.
55. Linz W, Schoelkens B, Han YF. Beneficial effects of the converting enzyme inhibitor, ramipril, in ischemic rat hearts. J Cardiovasc Pharmacol. 1986;8(suppl 10):S91-S99.
56. Fleetwood G, Boutinet S, Meier M, Wood JM. Involvement of the renin-angiotensin system in ischemic damage and reperfusion arrhythmias in the isolated perfused rat heart. J Cardiovasc Pharmacol. 1991;17:351-356.
57. Hasenfuss G, Mulieri LA, Leavitt BJ, Allen PD, Haeberle JR, Alpert NR. Alteration of contractile function and excitation-contraction coupling in dilated cardiomyopathy. Circ Res. 1992;70: 1225-1232.
58. Mulieri LA, Hasenfuss G, Leavitt B, Allen PD, Alpert NR. Altered myocardial force-frequency relation in human heart failure. Circulation. 1992;85:1743-1750.
59. Alpert NR, Hasenfuss G, Mulieri LA, Blanchard EM, Leavitt BJ, Ittleman F. The reorganization of the human and rabbit heart in response to hemodynamic overload. Eur Heart J. 1992;13(suppl D):9-16.
60. Fifer MA, Bourdillon PD, Lorell BH. Altered left ventricular diastolic properties during pacing-induced angina in patients with aortic stenosis. Circulation. 1986;74:675-683.
61. Gwathmey JK, Morgan JP. Altered calcium handling in experimental pressure-overload hypertrophy in the ferret. Circ Res. 1985; 57:836-843.
62. 2+-ATPase gene in pressure overload-induced cardiac hypertrophy in the rat. Circ Res. 1990;66:554-564.
63. Mercadier JJ, Lompre AM, Due P, Boheler KR, Fraysse J-B, Wisnewsky C, Allen PD, Komajda M, Schwartz K. Altered sarcoplasmic reticulum Ca-ATPase gene expression in the human ventricle during end-stage heart failure. J Clin Invest. 1990;85:305-309.
64. 2+-ATPaSe gene. Circ Res. 1992;71:9-17.
65. Arai M, Alpert NR, MacLennan DH, Barton P, Periasamy M. Alterations in sarcoplasmic reticulum gene expression in human heart failure. Circ Res. 1993;72:463-469.
66. Brillantes AM, Allen P, Takahashi T, Izumo S, Marks AR. Differences in cardiac calcium release channel (ryanodine receptor) expression in myocardium from patients with end-stage heart failure caused by ischemia versus dilated cardiomyopathy. Circ Res. 1992;71:18-26.
67. Litwin SE, Katz SE, Weinberg EO, Lorell BH, Douglas PS. Chronic ACE inhibition attenuates progression of systolic and diastolic dysfunction in rats with ascending aortic banding: a serial echo-Doppler study. Circulation. 1993;88(suppl I):I-527. Abstract.
68. Litwin SE, Morgan JP. Captopril enhances intracellular calcium handling and β-adrenergic responsiveness of myocardium from rats with post-infarction failure. Circ Res. 1992;71:797-807.
69. Neyses L, Vetter H. Impaired relaxation of the hypertrophied myocardium is potentiated by angiotensin II. J Hypertens. 1989; 7(suppl):S104-S105.
70. Rousseau MF, Gurne O, van Eyll C, Benedict CR, Pouleur H. Effects of benazeprilat on left ventricular systolic and diastolic function and neurohumoral status in patients with ischemic heart disease. Circulation. 1990;81(suppl III):III-123-III-129.
71. Friedrich SP, Lorell BH, Douglas PS, Gordon S, Grossman W, Benedict C, Hess OM, Krayenbuehl HP, Eberli F, Rousseau M, Pouleur H. Intracardiac ACE inhibition improves diastolic distensibility in patients with left ventricular hypertrophy due to aortic stenosis. Circulation. In press.