IL-10 inhibits cytokine production, vascular leakage, and swelling during T helper 1 cell-induced delayed-type hypersensitivity

Journal of Immunology

Volumn 153, Issue 9, 1994, Pages 3967-3978

  Li, Li ^a   Elliott, John F ^a   Mosmann, Timothy R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LYMPHOTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; DELAYED HYPERSENSITIVITY; DRUG EFFECT; EDEMA; FEMALE; FOOT PAD; HELPER CELL; HISTOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CAPILLARY PERMEABILITY; CYTOKINES; EDEMA; ERYTHROCYTES; FEMALE; HYPERSENSITIVITY, DELAYED; INTERLEUKIN-10; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; SHEEP; TH1 CELLS; TRANSFECTION;

EID: 0028029793     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Mosmann, T. R., and K. W. Moore. 1991. The role of IL-10 in cross-regulation of Th1 and Th2 responses. Immunol. Today 12:49.
2. Parish, C. R. 1972. The relationship between humoral and cell-mediated immunity. Transplant. Rev. 13:35.
3. Gajewski, T. F., and F. W. Fitch. 1988. Anti-proliferative effect of IFN-γ in immune regulation. I. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J. Immunol. 140:4245.
4. Fernandez-Botran, R., V. M. Sanders, T. R. Mosmann, and E. S. Vitetta. 1988. Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells. J. Exp. Med. 168:543.
5. Turk, J. L. 1980. Delayed Hypersensitivity. Elsevier, Amsterdam.
6. Dvorak, H. F., S. J. Galli, and A. M. Dvorak. 1980. Expression of cell-mediated hypersensitivity in vivo - recent advances. Int. Rev. Exp. Pathol. 21:119.
7. Richerson, H. B., H. F. Dvorak, and S. Leskowitz. 1970. Cutaneous basophil hypersensitivity. I. A new look at the Jones-Mote reaction, general characteristics. J. Exp. Med. 132:546.
8. Raffel, S., and J. M. Newel. 1958. The delayed 'hypersensitivity' induced by Ag-antibody complexes. J. Exp. Med. 108:823.
9. Nelson, D. S., and S. V. Boyden. 1964. The cutaneous reactivity of guinea pigs to pure protein Ags. I. A critical evaluation of methods for the induction of delayed-type hypersensitivity to pure proteins. Int. Arch. Allergy. 25:279.
10. Richerson, H. B., H. F. Dvorak, and S. Leskowitz. 1969. Cutaneous basophilic hypersensitivity: a new interpretation of the Jones-Mote reaction. J. Immunol. 103:1431.
11. Dvorak, H. F., A. M. Dvorak, B. A. Simpson, H. B. Richerson, S. Leskowitz, and M. J. Karnovsky. 1970. Cutaneous basophil hypersensitivity. II. A light and electron microscopic description. J. Exp. Med. 132:558.
12. Nakamura, S., H. Sanui, and K. Nomoto. 1986. Relationship between the tuberculin-type and Jones-Mote-type hypersensitivities: suppression of basophil infiltration by mycobacterial adjuvant. Immunology 58:397.
13. Askenase, P. W. 1976. Cutaneous basophil hypersensitivity uncovered in the cell transfer of classical tuberculin hypersensitivity. J. Immunol 117:741.
14. Cher, D. J., and T. R. Mosmann. 1987. Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by Th1 clones. J. Immunol. 138:3688.
15. Fong, T. A. T., and T. R. Mosmann. 1989. The role of IFN-γ in delayed type hypersensitivity mediated by Th1 clones. J. Immunol. 143:2887.
16. Fiorentino, D. F., M. W. Bond, and T. R. Mosmann. 1989. Two types of mouse T helper cell IV: Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170:2081.
17. De Waal Malefyt, R., J. Abrams, B. Bennett, C. G. Figdor, and J. E. de Vries. 1991. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:1209.
18. O'Garra, A., G. Stapleton, V. Dhar, M. Pearce, J. Schumacher, H. Rugo, D. Barbis, A. Stall, J. Cupp, K. Moore, P. Vieira, T. R. Mosmann, A. Whitmore, L. Arnold, G. Haughton, and M. Howard. 1990. Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10. Int. Immunol. 2:821.
19. O'Garra, A., R. Chang, N. Go, R. Hastings, G. Haughton, and M. Howard. 1992. Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10. Eur. J. Immunol. 22:711.
20. Fiorentino, D. F., A. Zlotnik, P. Vieira, T. R. Mosmann, M. Howard, K. W. Moore, and A. O'Garra. 1991. IL-10 acts on the Ag-presenting cell to inhibit cytokine production by Th1 cells. J. Immunol. 146:3444.
21. De Waal Malefyt, R., J. Haanen, H. Spits, M. G. Roncarolo, A. te Velde, C. Figdor, K. Johnson, R. Kastelein, H. Yssel, and J. E. de Vries. 1991. Interleukin 10 (IL-10) and viral IL-10 strongly reduce Ag-specific human T cell proliferation by diminishing the Ag-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J. Exp. Med. 174:915.
22. Ding, L., and E. M. Shevach. 1992. IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function. J. Immunol. 148:3133.
23. Fiorentino, D. F., A. Zlotnik, T. R. Mosmann, M. Howard, and A. O. O'Garra. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147:3815.
24. Gazzinelli, R. T., I. P. Oswald, S. L. James, and A. Sher. 1992. IL-10 inhibits parasite killing and nitrogen oxide production by IFN-γ-activated macrophages. J. Immunol. 148:1792.
25. Oswald, I. P., T, A. Wynn, A. Sher, and S. L. James. 1992. Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor α required as a costimulatory factor for interferon γ-induced activation. Proc. Natl. Acad. Sci. USA 89:8676.
26. Cunha, F. Q., S. Moncada, and F. Y. Liew. 1992. Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages. Biochem. Biophys. Res. Commun. 182:1155.
27. Thompson Snipes, L., V. Dhar, M. W. Bond, T. R. Mosmann, K. W. Moore, and D. M. Rennick. 1991. Interleukin 10: a novel stimulatory factor for mast cells and their progenitors. J. Exp. Med. 173:507.
28. Ghildyal, N., H. P. McNeil, M. F. Gurish, K. F. Austen, and R. L. Stevens. 1992. Transcriptional regulation of the mucosal mast cell-specific protease gene, MMCP-2, by interleukin 10 and interleukin 3. J. Biol. Chem. 267:8473.
29. Rousset, F., E. Garcia, T. Defrance, C. Peronne, N. Vezzio, D. H. Hsu, R. Kastelein, K. W. Moore, and J. Banchereau. 1992. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc. Natl. Acad. Sci. USA 89:1890.
30. Defrance, T., B. Vanbervliet, F. Briere, I. Durand, F. Rousset, and J. Banchereau. 1992. Interleukin 10 and transforming growth factor β cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A. J. Exp. Med. 175:671.
31. Yamamura, M., K. Uyemura, R. J. Deans, K. Weinberg, T. H. Rea, B. R. Bloom, and R. L. Modlin. 1991. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 254:277.
32. + lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc. Natl. Acad. Sci. USA 88:7011.
33. + subset expression in murine candidiasis: Th responses correlate directly with genetically determined susceptibility or vaccine-induced resistance. J. Immunol. 150: 925.
34. Rivas, J. M., and S. E. Ullrich. 1992. Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes: an essential role for keratinocyte-derived IL-10. J. Immunol. 149:3865.
35. Powrie, F., S. Menon, and R. L. Coffman. 1993. Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo. Eur. J. Immunol. 23:2223.
36. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
37. Espevik, T., and J. Nissen-Meyer. 1986. A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J. Immunol. Methods 95:99.
38. Kozak, M. 1987. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:8125.
39. Kozak, M. 1987. At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J. Mol Biol. 196: 947.
40. Elliott, J, F., G. R. Albrecht, A. Gilladoga, S. M. Handunnetti, J. Neequaye, G. Lallinger, J. N. Minjas, and R. J. Howard. 1990. Genes for Plasmodium falciparum surface Ags cloned by expression in COS cells. Proc. Natl. Acad. Sci. USA 87:6363.
41. Mosmann, T. R., J. H. Schumacher, D. F. Fiorentino, J. Leverah, K. W. Moore, and M. W. Bond. 1990. Isolation of mAbs specific for IL-4, IL-5, and IL-6, and a new Th2-specific cytokine, cytokine synthesis inhibitory factor (CSIF, IL-10), using a solid phase radioimmunoadsorbent assay. J. Immunol. 145:2938.
42. Cherwinski, H. M., J. H. Schumacher, K. D, Brown, and T. R. Mosmann. 1987. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J. Exp. Med. 166:1229.
43. Howard, M., T. Muchamuel, S. Andrade, and S. Menon. 1993. Interleukin 10 protects mice from lethal endotoxemia. J. Exp. Med. 177:1205.
44. Udaka, K., Y. Takeuchi, and H. Z. Movat. 1970. Simple method for quantitation of enhanced vascular permeability. Proc. Soc. Exp. Biol. Med. 133:1384.
45. Moore, K. W., P. Vieira, D. F. Fiorentino, M. L. Trounstine, T. A. Khan, and T. R. Mosmann. 1990. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science 248:1230.
46. Muhlradt, P. F., and H. O. Opitz. 1982. Clearance of interleukin 2 from the blood of normal and T cell-depleted mice. Eur. J. Immunol. 12:983.
47. Mosmann, T. R., and R. L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
48. Mosmann, T. R. 1994, Properties and functions of interleukin 10. Adv. Immunol. in press.
49. Kuhn, R., J. Lohler, D. Rennick, K. Rajewsky, and W. Muller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:1.
50. Scovern, H., and F. S. Kantor. 1982. Local passive transfer of delayed-type hypersensitivity in the mouse. J. Immunol. 129:25.
51. Vieira, P., R. de Waal Malefyt, M. N. Dang, K. E. Johnson, R. Kastelein, D. F. Fiorentino, J. E. DeVries, M. G. Roncarolo, T. R. Mosmann, and K. W. Moore. 1991. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. Proc. Natl. Acad. Sci. USA 88:1172.
52. Wogensen, L., X. Huang, and N. Sarvetnick. 1993. Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans. J. Exp. Med. 178:175.
53. Sironi, M., C. Munoz, T. Pollicino, A. Siboni, F. L. Sciacca, S. Bernasconi, A. Vecchi, F. Colotta, and A. Mantovani. 1993. Divergent effects of interleukin-10 on cytokine production by mononuclear phagocytes and endothelial cells. Eur. J. Immunol. 23:2692.
54. Macatonia, S. E., T. M. Doherty, S. C. Knight, and A. O'Garra. 1993. Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-γ production. J. Immunol. 150:3755.
55. Ferguson, T. A., P. Dube, and T. S. Griffith. 1994. Regulation of contact hypersensitivity by interleukin 10. J. Exp. Med. 179:1597.
56. Meade, R., P. W. Askenase, G. P. Geba, K. Neddermann, R. O. Jacoby, and R. D. Pasternak. 1992. Transforming growth factor β1 inhibits murine immediate and delayed type hypersensitivity. J Immunol. 149:521.
57. Mihara, M., M. Ikuta, Y. Koishihara, and Y. Ohsugi. 1991. Interleukin 6 inhibits delayed type hypersensitivity and the development of adjuvant arthritis. Eur. J. Immunol. 21:2327.