Ku80: Product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

Science

Volumn 265, Issue 5177, 1994, Pages 1442-1445

  Taccioli, Guillermo E ^a   Gottlieb, Tanya M ^b   Blunt, Tracy ^c   Priestley, Anne ^c   Demengeot, Jocelyne ^a   Mizuta, Ryushin ^a   Lehmann, Alan R ^c   Alt, Frederick W ^a   Jackson, Stephen P ^b   Jeggo, Penny A ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DNA DEPENDENT PROTEIN KINASE; DOUBLE STRANDED DNA; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHO CELL; DNA REPAIR; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; V(D)J RECOMBINATION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0028025020     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.8073286     Document Type: Article

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52. We thank A. Kuhn for purified mouse Ku; M. Knuth, N. Thompson, R. Burgess, and J. Flint for mAbs; and W. Reeves for Ku80 cDNA. The substrates of pJH200 and pJH290 were provided by J. Hesse and M. Gellert, and the XR-1 cell line was a gift from T. Stamato. We thank G. Silverman, J. Wagstaff, A. Beggs, R. Swirski, and T. Lindahl for discussions. Research in S.P.'s laboratory is funded principally by grant SP2143/0101 from the Cancer Research Campaign (CRC). T.M.G. is supported by a CRC studentship. Research in the MRC Cell Mutation Unit was supported in part by Commission of European Communities grants F13PCT920007 and ERBSC1CT920823. Research in F.W.A.'s laboratory is supported by NIH grant A.I. 20047, the Howard Hughes Medical Institute, and a postdoctoral fellowship from Irvington Institute (G.E.T.). G.E.T. is a special fellow of the Leukemia Society of America.