The ubiquitin-proteasome proteolytic pathway

Cell

Volumn 79, Issue 1, 1994, Pages 13-21

  Ciechanover, Aaron ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; CYCLINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; ONCOPROTEIN; PHYTOCHROME; PROTEASOME; UBIQUITIN;

ENZYME ACTIVITY; ENZYME SPECIFICITY; MOLECULAR RECOGNITION; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; REVIEW; TRANSCRIPTION REGULATION;

ANIMAL; CYSTEINE ENDOPEPTIDASES; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; UBIQUITINS;

EID: 0028018268     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90396-4     Document Type: Review

References (61)

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3. Activation-induced ubiquitination of the T cell antigen receptor
4. A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein
5. Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATα2 repressor
6. Accumulation of p53 in a mutant céll line defective in ubiquitin pathway
7. Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein E2
8. A 26S protease subunit that binds ubiquitin conjugates
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12. Ubiquitin C-terminal hydrolase activity associated with the 26S protease complex
13. γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes
14. S cerevisiae 26S protease mutants arrest cell division in G2/metaphase
15. A major conjugating system in wheat germ extracts involves a 15-kDa ubiquitin conjugating enzyme (E2) homologous to yeast UBC4/UBC5
16. Cyclin is degraded by the ubiquitin pathway
17. Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit
18. The ubiquitin-activating enzyme E1 is required for stress-induced lysosomal degradation of cellular proteins
19. Proteinase yscE the yeast proteasome/multicatalytic multifunctional proteinase mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival
20. PRE2 highly homologous to the human major histocompatibility complex-linked Ring10 gene codes for a yeast proteasome unit necessary for chymotryptic activity and degradation of ubiquitinated proteins
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27. Purification of two high molecular weight proteases from rabbit reticulocyte lysate
28. Cloning and expression of the cDNA for E6-AP a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53
29. The ubiquitin-conjugation system
30. The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants
31. Ubiquitin-activating enzyme E1 is associated with maturation of autophagic vacuoles
32. Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation
33. Both cyclin AΔ60 and BΔ97 are stable and arrest cells in M-phase but only cyclin BΔ97 turns on cyclin destruction
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35. Degradation of Gα by the N-end rule pathway
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37. A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation
38. Ligand-dependent polyubiquitination of c-kit gene product a possible mechanism of receptor down modulation in M07e cells
39. Ligand-induced polyubiquitination of the platelet-derived growth factor β-receptor
40. Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination
41. The Drosophila bendless gene encodes a neural protein related to ubiquitin-conjugating enzymes
42. 2 in Mos
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44. Ubiquitin and the proteasome are required for processing the NF-κB1 precursor and the activation of NF-κB
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48. Structural features of the 26S proteasome complex
49. The multicatalytic and 26 S proteases
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51. Amino acid sequences common to rapidly degraded proteins the PEST hypothesis
52. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
53. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
54. Red light-induced formation of ubiquitin-phytochrome conjugates identification of possible intermediates of phytochrome degradation
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56. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain
57. The N-end rule
58. Demonstration of two distinct high-molecular weight proteases in rabbit reticulocytes one of which degrades ubiquitin conjugates
59. The PAS2 protein essential for peroxisome biogenesis is related to ubiquitin-conjugating enzymes
60. The neuron-specific protein PGP 95 is a ubiquitin carboxyl-terminal hydrolase
61. MHC-encoded proteasome subunits LMP2 and LMP7 are not required for efficient antigen presentation