Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine

Proceedings of the National Academy of Sciences of the United States of America

Volumn 91, Issue 3, 1994, Pages 1143-1147

  Cowman, Alan F ^a   Galatis, Denise ^a   Thompson, Jennifer K ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

chloroquine; drug resistance; malaria; P glycoprotein

Indexed keywords

CHLOROQUINE; GLYCOPROTEIN P; HALOFANTRINE; MEFLOQUINE; QUININE;

ARTICLE; CHROMOSOME 5; CROSS RESISTANCE; GENE AMPLIFICATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MALARIA; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; RESTRICTION MAPPING;

CINCHONA PUBESCENS; PLASMODIUM FALCIPARUM;

EID: 0028014644     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.91.3.1143     Document Type: Article

References (21)

1. Krogstad, D. J., Gluzman, I. Y., Kyle, D. E., Oduola, A. M. & Martin, S. K. (1987) Science 238, 1283-1285.
2. Bray, P. G., Howells, R. E., Ritchie, G. Y. & Ward, S. A. (1992) Biochem. Paramacol. 44, 1317-1324.
3. Foote, S. J., Thompson, J. K., Cowman, A. F. & Kemp, D. J. (1989) Cell 57, 921-930.
4. Wilson, C. M., Serrano, A. E., Wasley, A., Bogenschutz, M. P., Shankar, A. H. & Wirth, D. F. (1989) Science 244, 1184-1186.
5. Foote, S. J., Kyle, D. E., Martin, R. K., Oduola, A. M., Forsyth, K., Kemp, D. J. & Cowman, A. F. (1990) Nature (London) 345, 255-258.
6. Cowman, A. F., Karcz, S., Galatis, D. & Culvenor, J. G. (1991) J. Cell Biol. 113, 1033-1042.
7. Barnes, D. A., Foote, S. J., Galatis, D., Kemp, D. J. & Cowman, A. F. (1992) EMBO J. 11, 3067-3075.
8. Oduola, A. M., Milhous, W. K., Weatherly, N. F., Bowdre, J. H. & Desjardins, R. E. (1988) Exp. Parasitol. 67, 354-360.
9. Bianco, A. E., Battye, F. L. & Brown, G. V. (1986) Exp. Parasitol. 62, 275-282.
10. Trager, W. & Jenson, J. B. (1978) Nature (London) 273, 621-622.
11. Chu, G., Vollrath, D. & Davis, R. (1986) Science 234, 1582-1585.
12. Cowman, A. F. & Lew, A. M. (1989) Mol. Cell. Biol. 9, 5182-5188.
13. Limpaiboon, T., Shirley, M. W., Kemp, D. J. & Saul, A. (1991) Mol. Biochem. Parasitol. 47, 197-206.
14. Cowman, A. F. & Galatis, D. (1991) Exp. Parasitol. 73, 269-275.
15. Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B. & Erlich, H. A. (1988) Science 239, 487-491.
16. Brasseur, P., Kouamouo, J. & Druilhe, P. (1991) J. Infect. Dis. 164, 625-626.
17. Brasseur, P., Kouamouo, J., Moyou-Somo, R. & Druilhe, P. (1992) Am. J. Trop. Med. Hyg. 46, 1-7.
18. Brasseur, P., Kouamouo, J., Moyou-Somo, R. & Druilhe, P. (1992) Am. J. Trop. Med. Hyg. 46, 8-14.
19. Triglia, T., Foote, S. J., Kemp, D. J. & Cowman, A. F. (1991) Mol. Cell. Biol. 11, 5244-5250.
20. Cowman, A. F. (1991) Parasitol. Today 7, 70-76.
21. Wilson, C. M., Volkman, S. K., Thaithong, S., Martin, R. K., Kyle, D. E., Milhous, W. K. & Wirth, D. F. (1993) Mol. Biochem. Parasitol. 57, 151-160.