Signal transduction by lymphocyte antigen receptors

Cell

Volumn 76, Issue 2, 1994, Pages 263-274

  Weiss, Arthur ^a   Littman, Dan R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; T LYMPHOCYTE RECEPTOR;

GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; LYMPHOCYTE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMAL; ANTIGENS, CD45; B-LYMPHOCYTES; CALCINEURIN; CALCIUM; CALMODULIN-BINDING PROTEINS; CELL MEMBRANE; CELL NUCLEUS; HUMAN; MACROMOLECULAR SYSTEMS; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLINOSITOLS; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN-TYROSINE KINASE; PROTO-ONCOGENE PROTEIN P21(RAS); RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, ANTIGEN, T-CELL; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0028014460     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90334-4     Document Type: Review

References (125)

1. lck
2. Molecular mimicry of the antigen receptor signaling motif by transmembrane proteins of the Epstein-Barr virus and the bovine leukemia virus
3. fyn
4. Cross-linking CD4 by human immunodeficiency virus gp 120 primes T cells for activation-induced apoptosis
5. The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB
6. A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines
7. lck and Ti(TCR)/CD3 complexes
8. Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells
9. Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates
10. Differential activation requirements for virgin and memory T cells
11. Signal transduction by T- and B-cell antigen receptors converging structures and concepts
12. Identification of a CD4 binding site on the β2 domain of HLA-DR molecules
13. CD19 lowering the threshold for antigen receptor stimulation of B lymphocytes
14. Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes
15. The ζ-chain is associated with a tyrosine kinase and upon T cell antigen receptor stimulation associates with ZAP-70 a 70 kilodalton tyrosine phosphoprotein
16. ZAP-70 A 70kd protein-tyrosine kinase that associates with the TCR ζ chain
17. Another view of the selective model of thymocyte selection
18. csk
19. The B cell antigen receptor complex association of Igα and Igβ with distinct cytoplasmic effectors
20. Identification of calcineurin as a key signaling enzyme in T-lymphocyte activation
21. lck association with CD4 is required for the interaction between CD4 and the TCR/CD3 complex and for optimal antigen stimulation
22. fyn)
23. Tyr 527 is phosphorylated in pp60c-src implication for regulation
24. Extracellular signals and reversible protein phosphorylation what to Mek of it all
25. lck
26. Phospholipase C-γ1 association with CD3 structure in T cells
27. fyn
28. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes
29. Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase
30. The regulation and function of p21ras in T cells
31. The CD19-CR2-TAPA-1 complex CD45 and signaling by the antigen receptor of B lymphocytes
32. fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain
33. Lymphocyte lineage-restricted tyrosine-phosphorylated proteins that bind PLCγ1 SH2 domains
34. lck with CD4 in antigen-specific signal transduction in T cells
35. Membrane Ig cross-linking regulates phosphatidylinositol 3-kinases in B lymphocytes
36. Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTPase-Activating Protein (GAP) and two GAP-associated proteins
37. The protein-tyrosine kinase inhibitor herbimycin A but not genestein specifically inhibits signal transduction by the T cell antigen receptor
38. Tyrosine kinase-stimulated guanine nucleotide exchange activity of vav in T cell activation
39. Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation
40. lck with CD4 inhibits the induction of growth through the αβ T-cell receptor
41. 2 upon cross-linking of membrane Ig on murine B lymphocytes
42. Rescue of signaling by a chimeric protein containing the cytoplasmic domain of CD45
43. Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck fyn and c-src tyrosine protein kinases
44. B lymphocyte activation is accompanied by phosphorylation of a 72-kda protein-tyrosine kinase
45. Transmembrane signaling by the T cell antigen receptor perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores
46. The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways
47. Functional characterization of a signal transducing motif present in the T cell receptor ζ chain
48. Nuclear factor of activated T cells contains Fos and Jun
49. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun
50. Inhibition of tyrosine phosphorylation prevents T cell receptor-mediated signal transduction
51. Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45
52. lck on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line
53. lck association
54. Differential signaling through the lgα and lgβ components of the B cell antigen receptor
55. Normal B lymphocyte development but impaired T cell maturation in CD45-exon 6 protein tyrosine phosphatase-deficient mice
56. T cell activation by clustered tyrosine kinases
57. MHC class II interaction with CD4 mediated by a region analogous the MHC class I binding site for CD8
58. Tyrosine phosphatase CD45 is essential for coupling T cell antigen receptor to the phosphatidylinositol pathway
59. Tyrosine phosphatase CD45 is required for both T cell antigen receptor- and CD2-mediated activation of a protein-tyrosine kinase and interleukin 2 production
60. B cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72 Lyn and Fyn
61. Signal transduction through CD4 stimulatory versus inhibitory activity is regulated by CD4 proximity to the CD3/T cell receptor
62. The interaction of CD4 with CD3/Ti regulates tyrosine phosphorylation of substrates during T cell activation
63. CD8 surface levels alter the fate of αβ-TCR expressing thymocytes in transgenic mice
64. Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3ε
65. lck in thymopoiesis
66. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
67. The v-Src SH3 domain binds phosphatidylinositol 3′-kinase
68. Tyrosine phosphorylation of vav a proto-oncogene combining SH2 and SH3 domains with motifs found in transcriptional factors
69. lck
70. lck by the CD45 phosphotyrosine phosphatase
71. Intrathymic signalling in immature CD4+CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain
72. Stimulation of map-2 kinase activity in T lymphocytes by anti-CD3 or anti-Ti monoclonal antibody is partially dependent on protein kinase C
73. Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex
74. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
75. Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling
76. CSK a protein-tyrosine involved in regulation of Src family kinases
77. Expression of CD45 alters phosphorylation of the lck — encoded tyrosine protein kinase in murine lymphoma T-cell lines
78. Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation
79. ras with GAP, exchange factors, and its biological effector target
80. fyn mediates binding to phosphatidylinositol 3-kinase in T cells
81. ras mediates control of IL-2 gene promoter function in T cell activation
82. Antigen receptor tail clue
83. Antigen receptors on B lymphocytes
84. The level of CD8 expression can determine the outcome of thymic selection
85. Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides
86. Sequence requirements for induction of cytolysis by the T cell antigen/Fc receptor ζ chain
87. CD4 CD8 and the TCR-CD3 complex a novel class of protein-tyrosine kinase receptor
88. Evidence for a physical association of CD4 and the CD3αβ T cell receptor
89. lck with FcγRIIIA (CD16) in natural killer cells
90. Tyrosine kinases and tyrosine-based activation motifs
91. fyn protein-tyrosine kinase association by chemical cross-linking
92. How receptor tyrosine kinases activate Ras
93. The mechanism of action of cyclosporin A and FK506
94. T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-γ1
95. CD22 a B cell-specific immunoglobulin superfamily member is a sialic acid-binding lectin
96. T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf-associated kinase activity via a protein kinase C-dependent pathway
97. CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck
98. The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and α2–6 sialyltransferase CD75 on B cells
99. fyn mutant mice display differential signaling in thymocytes and peripheral T cells
100. Protein-tyrosine-phosphatase CD45 is phosphorylated transiently on tyrosine upon activation of Jurkat T cells
101. Genetic evidence for the involvement of the Lck tyrosine kinase in signal transduction through the T cell antigen receptor
102. The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation
103. 2+ fluxes from the biological responses of a T-cell hybridoma
104. Molecular cloning of a porcine gene syk that encodes a 72-kda protein-tyrosine kinase showing high susceptibility to proteolysis
105. CD45 a prototype for transmembrane protein tyrosine phosphatases
106. fyn following T cell antigen receptor cross-linking
107. CD19 of B cells as a surrogate kinase insert region to bind phosphati-dylinositol 3-kinase
108. Development of mature CD8+ thymocytes selection rather than instruction?
109. Dual antigen recognition by B cells
110. Constitutive tyrosine phosphorylation of the T cell receptor (TCR) ζ subunit: Regulation of TCR-associated protein kinase activity by TCRζ
111. CD8 inhibits signal transduction through the T cell receptor in CD4-CD8- thymocytes form T cell receptor transgenic mice reconstituted with a transgenic CD8 alpha molecule
112. lck
113. Regulation of TCR signaling by CD45 lacking transmembrane and extracellular domains
114. CD4 CD8 and tyrosine kinases in thymic selection
115. A tyrosine-phosphorylated 70-kda protein bind a photoaffinity analogue of ATP and associates with both the ζ and CD3 components of the activated T cell antigen receptor
116. Tandem SH2 domains of ZAP-70 binds to T cell antigen receptor ζ and CD3ε from activated Jurkat T cells
117. Association of the tyrosine kinase LCK with phospholipase C-γ1 after stimulation of the T cell antigen receptor
118. The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules
119. Molecular and genetic insights into T cell antigen receptor structure and function
120. T cell antigen receptor signal transduction a tale of tails and cytoplasmic protein-tyrosine kinases
121. Cell surface molecules and early events involved in human T lymphocyte activation
122. Stimulation of the T cell antigen receptor induces tyrosine phosphorylation of phospholipase C-γ1
123. ras function is important for T cell antigen receptor and protein kinase C regulation of nuclear factor of activated T cells
124. A kinase-independent function of lck in potentiating antigen-specific T cell activation
125. lck correlates with impaired in vitro and lack of expression in vivo