Origin, structure and motifs of naturally processed MHC class II ligands

Current Opinion in Immunology

Volumn 6, Issue 1, 1994, Pages 45-51

  Rötzschke, Olaf ^a   Falk, Kirsten ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANE PROTEIN; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

AMINO ACID SEQUENCE; MAJOR HISTOCOMPATIBILITY COMPLEX; PROTEIN PROCESSING; PROTEIN STRUCTURE; REVIEW;

AMINO ACID SEQUENCE; ANIMAL; BINDING SITES; EPITOPES; EVOLUTION; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMAN; LIGANDS; MOLECULAR SEQUENCE DATA; PEPTIDES; SUPPORT, NON-U.S. GOV'T;

EID: 0028011845     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/0952-7915(94)90032-9     Document Type: Article

References (52)

1. Evolution of the Major Histocompatibility Complex
2. Refined Structure of the Human Histocompatibility Antigen HLA-A2 at 2.6 Å Resolution
3. Three-dimensional Structure of the Human Class Il Histocompatibility Antigen HLA-DR
4. Naturally Occuring Peptide Antigens Derived from the MHC Class I-Restricted Processing Pathway
5. Intracellular Traffic and Antigen Processing
6. Cellular Studies on Antigen Presentation by Class II MHC Molecules
7. k
8. Minute Quantities of a Single Immunodomminant Foreign Epitope are Presented as Large Nested Sets by Major Histocompatibility Complex Class lI Molecules
9. Specificity and Promiscuity among Naturally Processed Peptides Bound to HLA-DR Alleles
10. Predominant Naturally Processed, Peptides Bound to HLA-DR1 are Derived from MHC-Related Molecules and are Heterogenous in Size
11. Chemistry and Functional Role of the Invariant Chain
12. Co-Localization of Molecules Involved in Antigen Processing and Presentation in an Early Endocytic Compartment
13. Segregation of MHC Class II Molecules from MHC Class I Molecules in the Golgi Complex for Transport to Lysosomal Compartments
14. Immunogenic Peptides Bind to Class II MHC Molecules in an Early Lysosomal Compartment
15. Processing Pathways for Presentation of Cytosolic Antigen to MHC Class II-Restricted T Cells
16. Invariant Chain Association with HLA-DR Molecules Inhibits Immunogenic Peptide Binding
17. Allele-Specific Motifs Revealed by Sequencing of Self-Peptides Eluted from MHC Molecules
18. d
19. Sequence Analysis of Peptides Bound to MHC Class II Molecules
20. Truncation Variants of Peptides Isolated from MHC Class II Molecules Suggests Sequence Motifs
21. Invariant Chain Peptides in Most HLA-DR Molecules of an Antigen-Processing Mutant
22. Capacity of Intact Proteins to Bind to MHC Class II Molecules
23. Determinant Protection. A Hypothesis for the Activity of Immune Response Genes in the Processing and Presentation of Antigens by Macrophages
24. MHC Molecules Protect T Cell Epitopes against Proteolytic Destruction
25. Characterization of Endogenous Peptides Bound to Purified HLA-DR Molecules and Their Absence from Invariant Chain-Associated αβ Dimers
26. Identification of Naturally Processed Viral Nonapeptides Allows Their Quantification in Infected Cells and Suggests an Allele-Specific T Cell Epitope Forcast
27. Identification of Self Peptides to Purified HLA-B27
28. Different Length Peptides Bind to HLA-Aw68 at Their Ends but Bulge out in the Middle
29. Peptide Binding to HLA-DRI: A Peptide with most Residues Substituted to Alanine Retains MHC Binding
30. Truncation Analysis of Several DR Binding Epitopes
31. On the Interaction of Promis cuous Antigenic Peptides with Different DR Alleles. Identification of Common Structural Motifs
32. Functional Analysis of DR17(DR3)-Restricted Mycobacterial T Cell Epitopes Reveals DR17-Binding Motif and Enables the Design of Allele-Specific Competitor Peptides
33. Conformational and Structural Characteristics of Peptides Binding to HLA-DR Molecules
34. Searching for Peptide Ligands with an Epitope Library
35. Random Peptide Libraries: A Source of Specific Protein Binding Molecules
36. Identification of a Motif for HLA DR1 Binding Peptides Using M13 Display Libraries
37. Promicuous and Allele-Specific Anchors in HLA-DR-Binding Peptides
38. Pool Sequencing of Natural HLA-DR, DQ, and DP Ligands Reveals Detailed Peptide Motifs, Constraints of Processing, and General Rules
39. Natural Peptide Ligand Motifs of Two HLA Molecules Associated with Myasthenia Gravis
40. The Set of Naturally Processed Peptides Displayed by DR Molecules is Tuned by Polymorphism of Residue 86
41. Differential Effect of Polymorphism at HLA-DR1 β-Chain Positions 85 and 86 on Binding and Recognition of DR1-Restricted Antigenic Peptides
42. Consensus Motifs and Peptide Ligands of MHC Class I Molecules
43. Peptide Motifs of HLA-B35 and -B37 Molecules
44. Chemistry of Peptide Interactions with MHC Proteins
45. Universially Immunogenic TCell Epitopes Promiscuous Binding to Human MHC Class II and Promiscuous Recognition by T-Cells
46. A Malaria T-Cell Epitopic Recognized in Association with most Mouse and Human MHC Class II Molecules
47. HLA-DR Molecules from an Antigen-Processing Mutant Cell Line are Associated with Invariant Chain Peptides
48. The Segment of Invariant Chain that is Critical for Association with Major Histocompatibility Complex Class II Molecules Contains the Sequence of a Peptide Eluted from Class II Polypeptides
49. 2-Terminal Including Proline as a Stop Signal for Trimming
50. Membrane-Bound Peptidases of Lymphocytes-Functional Implications
51. HLA DR4w4-Binding Motifs Illustrate the Biochemical Basis of Degeneracy and Specificity in Peptide-DR Interactions