Structure-Activity Studies of Benzimidazole-Based DNA-Cleaving Agents. Comparison of Benzimidazole, Pyrrolobenzimidazole, and Tetrahydropyridobenzimidazole Analogues

Journal of Medicinal Chemistry

Volumn 37, Issue 1, 1994, Pages 78-92

  Skibo, Edward B ^a   Islam, Imadul ^a   Heileman, Matthew J ^a   Schulz, William G ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 DIMETHYLAMINOETHYL) 9 METHOXY 5 NITROPYRAZOLO[3,4,5 KL]ACRIDINE; 3,6 BIS(5 CHLORO 2 PIPERIDYL) 2,5 PIPERAZINEDIONE; 5 (1 AZIRIDINYL) 3 HYDROXYMETHYL 2 (3 HYDROXY 1 PROPENYL) 1 METHYL 4,7 INDOLEDIONE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; BISANTRENE; CELL DNA; PIPERAZINEDIONE; PYRROLO[1,2 A]BENZIMIDAZOLE DERIVATIVE; TETRAHYDROPYRIDO[1,2 A]BENZIMIDAZOLE DERIVATIVE; TRETAMINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN CANCER; CANCER CELL DESTRUCTION; CONTROLLED STUDY; DNA ALKYLATION; DNA CLEAVAGE; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; KIDNEY CANCER; LEUKEMIA CELL; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MELANOMA CELL; OVARY CANCER; STRUCTURE ACTIVITY RELATION;

ALKYLATION; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BENZIMIDAZOLES; COMPARATIVE STUDY; DNA; LEUKEMIA; MAGNETIC RESONANCE SPECTROSCOPY; MELANOMA; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PYRIDINES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0028010991     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00027a010     Document Type: Article

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